Patents by Inventor David A. Seiler

David A. Seiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240108709
    Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.
    Type: Application
    Filed: March 20, 2023
    Publication date: April 4, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
  • Patent number: 11248071
    Abstract: The invention relates to fluoropolymer filament for use in 3-D printing, and 3-D printed fluoropolymer articles having low warpage, excellent chemical resistance, excellent water resistance, flame resistance, and good mechanical integrity. Additionally, the articles of the invention have good shelf life without the need for special packaging. In particular, the invention relates to filament, 3-D printed polyvinylidene fluoride (PVDF) articles, and in particular material extrusion 3-D printing. The articles may be formed from PVDF homopolymers, copolymers, such as KYNAR® resins from Arkema, as well as polymer blends with appropriately defined low shear melt viscosity. The PVDF may optionally be a filled PVDF formulation. The physical properties of the 3-D printed articles can be maximized and warpage minimized by optimizing processing parameters.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: February 15, 2022
    Assignee: Arkema Inc.
    Inventors: David Shin-Ren Liu, Gregory S. O'Brien, David A. Seiler, Mark Aubart, James J. Henry, Thomas Roland
  • Publication number: 20210171793
    Abstract: A fluoropolymer-based powdered composition is disclosed. The fluoropolymer has a very low melt viscosity, of less than 2 kilopoise (kP) at 230° C. and 100 s?1 and molecular weights of from 15 kDa to 200 kDa. The composition can be used for powder coating or rotolining processes. The coatings or interior surfaces of the coated or rotolined parts exhibit roughness values, Ra, of less than 25 ?in (0.64 ?m) corresponding to very smooth surfaces. The coating exhibit very good adhesion to substrates with and without surface preparation as well as very good adhesion to substrates with and without primer.
    Type: Application
    Filed: May 7, 2019
    Publication date: June 10, 2021
    Inventors: David A. SEILER, James T. GOLDBACH, George FISHER
  • Publication number: 20200247923
    Abstract: A lubricant composition includes a base oil present in an amount of greater than 70 parts by weight per 100 parts by weight of the lubricant composition and an antioxidant. The antioxidant has the structure: wherein each X is independently C-A or N, so long as at least one X is N but no more than two of X are N. Moreover, A is H, cyano or an electron donating group that: (1) has an atom having at least one lone pair of electrons that is bonded directly to the aromatic ring; or (2) is an aryl group or alkyl group. Further, each R is independently H, an alkyl group, or aryl group and each R? is independently an alkyl group or an aryl group.
    Type: Application
    Filed: April 23, 2020
    Publication date: August 6, 2020
    Inventors: DAVID SHIN-REN LIU, Gregory S. O'BRIEN, David A. SEILER
  • Patent number: 10633468
    Abstract: The invention relates to fluoropolymer filament for use in 3-D printing, and 3-D printed fluoropolymer articles having low warpage, excellent chemical resistance, excellent water resistance, flame resistance, and good mechanical integrity. Additionally, the articles of the invention have good shelf life without the need for special packaging. In particular, the invention relates to filament, 3-D printed polyvinylidene fluoride (PVDF) articles, and in particular material extrusion 3-D printing. The articles may be formed from PVDF homopolymers, copolymers, such as KYNAR® resins from Arkema, as well as polymer blends with appropriately defined low shear melt viscosity. The PVDF may optionally be a filled PVDF formulation. The physical properties of the 3-D printed articles can be maximized and warpage minimized by optimizing processing parameters.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: April 28, 2020
    Assignee: Arkema Inc.
    Inventors: David Shin-Ren Liu, Gregory S. O'Brien, David A. Seiler
  • Patent number: 10570230
    Abstract: The invention relates to a heterogeneous, co-continuous copolymer composition of vinylidene fluoride and at least one other comonomer. Preferred comonomers are hexafluoropropylene and perfluoroalkylvinyl ether. The co-continuous morphology is provide by first forming a first phase polymer, then adding one or more comonomers before half of the original monomer stream has been added, and at an effective level to cause phase separation of the copolymer. The co-continuous morphology provides a means for incorporating a high level of comonomer into the copolymer with little or no adverse effect on the melting temperature. The morphology also provides the copolymer composition with a unique combination of properties, including a high melting point, good flexibility and good low temperature impact resistance. The unique properties of the polymer make it useful in end-use application where those properties provide performance advantages, such as in the wire and cable market, and in oil and gas applications.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: February 25, 2020
    Assignee: Arkema Inc.
    Inventors: Adam W. Freeman, James J. Henry, David A. Seiler
  • Patent number: 10434478
    Abstract: The invention relates to a porous separation article having a fluoropolymer, polyamide, PEEK, or PEKK binder interconnecting one or more types of interactive powdery materials or fibers. The interconnectivity is such that the binder connects the powdery materials or fibers in discrete spots rather than as a complete coating, allowing the materials or fibers to be in direct contact with, and interact with a fluid. The resulting article is a formed multicomponent, interconnected web, with porosity. The separation article is useful in water purification, as well as in the separation of dissolved or suspended materials in both aqueous and non-aqueous systems in industrial uses. The separation article can function at ambient temperature, as well as at elevated temperatures.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: October 8, 2019
    Assignee: Arkema Inc.
    Inventors: Sean M. Stabler, Thomas F. Roland, David A. Seiler, Ramin Amin-Sanayei, Walter P. Kosar
  • Publication number: 20190127500
    Abstract: The invention relates to fluoropolymer filament for use in 3-D printing, and 3-D printed fluoropolymer articles having low warpage, excellent chemical resistance, excellent water resistance, flame resistance, and good mechanical integrity. Additionally, the articles of the invention have good shelf life without the need for special packaging. In particular, the invention relates to filament, 3-D printed polyvinylidene fluoride (PVDF) articles, and in particular material extrusion 3-D printing. The articles may be formed from PVDF homopolymers, copolymers, such as KYNAR® resins from Arkema, as well as polymer blends with appropriately defined low shear melt viscosity. The PVDF may optionally be a filled PVDF formulation. The physical properties of the 3-D printed articles can be maximized and warpage minimized by optimizing processing parameters.
    Type: Application
    Filed: March 31, 2017
    Publication date: May 2, 2019
    Inventors: David Shin-Ren LIU, Gregory S. O'BRIEN, David A. SEILER
  • Patent number: 10259936
    Abstract: The invention relates to fluoropolymer filament for use in 3-D printing, and 3-D printed fluoropolymer articles having low warpage, excellent chemical resistance, excellent water resistance, flame resistance, and good mechanical integrity. Additionally, the articles of the invention have good shelf life without the need for special packaging. In particular, the invention relates to filament, 3-D printed polyvinylidene fluoride (PVDF) articles, and in particular material extrusion 3-D printing. The articles may be formed from PVDF homopolymers, copolymers, such as KYNAR® resins from Arkema, as well as polymer blends with appropriately defined low shear melt viscosity. The PVDF may optionally be a filled PVDF formulation. The physical properties of the 3-D printed articles can be maximized and warpage minimized by optimizing processing parameters.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: April 16, 2019
    Assignee: Arkema Inc.
    Inventors: David Shin-Ren Liu, Gregory S. O'Brien, David A. Seiler
  • Patent number: 10155619
    Abstract: The invention relates to chemically resistant structures that float on top of a liquid to reduce the level of evaporation from the liquid. The liquid could be in a small container or vat, or in a larger pool, pond, or reservoir. The structure is preferably a foamed material of a polyamide or fluoropolymer, or may be a hollow or foamed structure having a polyamide or fluoropolymer outer layer. The structures covering the liquid may consist of a single structure or two or more discrete structures that partially or fully cover the surface of a liquid. The covering is especially useful where the fluid contains toxic, reactive or corrosive substances. One preferred structure is a polyvinylidene fluoride foam structure (such as a KYNAR from Arkema Inc) at about 0.1-36 inches in length/diameter.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: December 18, 2018
    Assignee: Arkema Inc.
    Inventors: Sean M. Stabler, Leo T. Hutton, David A. Seiler
  • Publication number: 20180099250
    Abstract: The invention relates to a porous separation article having a fluoropolymer, polyamide, PEEK, or PEKK binder interconnecting one or more types of interactive powdery materials or fibers. The interconnectivity is such that the binder connects the powdery materials or fibers in discrete spots rather than as a complete coating, allowing the materials or fibers to be in direct contact with, and interact with a fluid. The resulting article is a formed multicomponent, interconnected web, with porosity. The separation article is useful in water purification, as well as in the separation of dissolved or suspended materials in both aqueous and non-aqueous systems in industrial uses. The separation article can function at ambient temperature, as well as at elevated temperatures.
    Type: Application
    Filed: December 11, 2017
    Publication date: April 12, 2018
    Inventors: Sean M. Stabler, Thomas F. Roland, David A. Seiler, Ramin Amin-Sanayei, Walter P. Kosar
  • Publication number: 20180044456
    Abstract: The invention relates to a heterogeneous, co-continuous copolymer composition of vinylidene fluoride and at least one other comonomer. Preferred comonomers are hexafluoropropylene and perfluoroalkylvinyl ether. The co-continuous morphology is provide by first forming a first phase polymer, then adding one or more comonomers before half of the original monomer stream has been added, and at an effective level to cause phase separation of the copolymer. The co-continuous morphology provides a means for incorporating a high level of comonomer into the copolymer with little or no adverse effect on the melting temperature. The morphology also provides the copolymer composition with a unique combination of properties, including a high melting point, good flexibility and good low temperature impact resistance. The unique properties of the polymer make it useful in end-use application where those properties provide performance advantages, such as in the wire and cable market, and in oil and gas applications.
    Type: Application
    Filed: February 5, 2016
    Publication date: February 15, 2018
    Inventors: Adam W. FREEMAN, James J. HENRY, David A. SEILER
  • Publication number: 20170368731
    Abstract: The invention relates to an extrusion-assisting agent containing low-viscosity thermoplastic fluorinated polymers and preferably not containing a synergist. The invention also relates to the use of the extrusion agent for extrusion in the form of monofilament or multifilament fibres or non-woven materials, and to the extrusion method.
    Type: Application
    Filed: December 10, 2015
    Publication date: December 28, 2017
    Inventors: Samuel Devisme, Jéôme CHAUVEAU, François BEAUME, James T. GOLDBACH, David A. SEILER
  • Patent number: 9839881
    Abstract: The invention relates to a porous separation article having a fluoropolymer or polyamide binder interconnecting one or more types of interactive powdery materials or fibers. The interconnectivity is such that the binder connects the powdery materials or fibers in discrete spots rather than as a complete coating, allowing the materials or fibers to be in direct contact with, and interact with a fluid. The resulting article is a formed multicomponent, interconnected web, with porosity. The separation article is useful in water purification, as well as in the separation of dissolved or suspended materials in both aqueous and non-aqueous systems in industrial uses. The separation article can function at ambient temperature, as well as at elevated temperatures.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: December 12, 2017
    Assignee: Arkema Inc.
    Inventors: Sean M. Stabler, Thomas F. Roland, David A. Seiler, Ramin Amin-Sanayei, Walter Kosar
  • Publication number: 20160101932
    Abstract: The invention relates to chemically resistant structures that float on top of a liquid to reduce the level of evaporation from the liquid. The liquid could be in a small container or vat, or in a larger pool, pond, or reservoir. The structure is preferably a foamed material of a polyamide or fluoropolymer, or may be a hollow or foamed structure having a polyamide or fluoropolymer outer layer. The structures covering the liquid may consist of a single structure or two or more discrete structures that partially or fully cover the surface of a liquid. The covering is especially useful where the fluid contains toxic, reactive or corrosive substances. One preferred structure is a polyvinylidene fluoride foam structure (such as a KYNAR from Arkema Inc) at about 0.1-36 inches in length/diameter.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 14, 2016
    Inventors: Sean M. Stabler, Leo T. HUTTON, David A. SEILER
  • Publication number: 20150231576
    Abstract: The invention relates to a porous separation article having a fluoropolymer or polyamide binder interconnecting one or more types of interactive powdery materials or fibers. The interconnectivity is such that the binder connects the powdery materials or fibers in discrete spots rather than as a complete coating, allowing the materials or fibers to be in direct contact with, and interact with a fluid. The resulting article is a formed multicomponent, interconnected web, with porosity. The separation article is useful in water purification, as well as in the separation of dissolved or suspended materials in both aqueous and non-aqueous systems in industrial uses. The separation article can function at ambient temperature, as well as at elevated temperatures.
    Type: Application
    Filed: October 1, 2013
    Publication date: August 20, 2015
    Inventors: Sean M. Stabler, Thomas F. Roland, David A. Seiler, Ramin Amin-Sanayei, Walter Kosar