Abstract: The present invention relates to antibodies capable of binding human CD123 and capable of binding the V?2 chain of a human V?9V?2 T cell receptor. The invention further relates to pharmaceutical compositions comprising the antibodies of the invention and to uses of the antibodies of the invention for medical treatment.

Abstract: A pellicle for a lithographic apparatus, the pellicle including nitridated metal silicide or nitridated silicon as well as a method of manufacturing the same. Also disclosed is the use of a nitridated metal silicide or nitridated silicon pellicle in a lithographic apparatus. Also disclosed is a pellicle for a lithographic apparatus including at least one compensating layer selected and configured to counteract changes in transmissivity of the pellicle upon exposure to EUV radiation as well as a method of controlling the transmissivity of a pellicle and a method of designing a pellicle.

Abstract: A connector assembly that includes a connector that has a ferrule and a latch. The latch is movable about a connection point. The connector assembly also includes a boot that is removably mounted to the connector. The boot is axially slidable to move the latch. The connector assembly also includes a locking assembly to selectively lock the boot from sliding axially relative to the connector.

Abstract: A method of manufacturing a pellicle for a lithographic apparatus, the method including locally heating the pellicle using radiative heating, and depositing coating material simultaneously on both sides of the pellicle, and pellicles manufactured according to this method. Also disclosed is the use of a multilayer graphene pellicle with a double-sided hexagonal boron nitride coating in a lithographic apparatus.

Abstract: The present disclosure provides maize plants exhibiting broad spectrum resistance to Northern Leaf Blight (NLB). Maize plants with multiple NLB resistance loci located in cis linkage on chromosome 8 are provided. Compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are further provided.

Abstract: The present invention relates to TWEAK-receptor agonists for use in the treatment of a cancer, wherein the TWEAK-receptor agonist is combined with immunotherapy of the cancer. The TWEAK-receptor agonist preferably is a multivalent ligand that causes clustering of TWEAK-receptors at the cell surface. A suitable TWEAK-receptor agonist is an agonistic anti-Fn14 antibody. The TWEAK-receptor agonist and immunotherapy be can further be combined with a SMAC mimetic in the treatment of cancer. The TWEAK-receptor agonist is useful, optionally in combination with a SMAC mimetic, to prevent resistance of a cancer to immunotherapy and/or to treat a cancer comprising tumor cells that are resistant to immunotherapy.

Abstract: The present invention relates to TWEAK-receptor agonists for use in the treatment of a cancer, wherein the TWEAK-receptor agonist is combined with immunotherapy of the cancer. The TWEAK-receptor agonist preferably is a multivalent ligand that causes clustering of TWEAK-receptors at the cell surface. A suitable TWEAK-receptor agonist is an agonistic anti-Fn14 antibody. The TWEAK-receptor agonist and immunotherapy be can further be combined with a SMAC mimetic in the treatment of cancer. The TWEAK-receptor agonist is useful, optionally in combination with a SMAC mimetic, to prevent resistance of a cancer to immunotherapy and/or to treat a cancer comprising tumor cells that are resistant to immunotherapy.

Abstract: An elevator device that can continuously evacuate any evacuee left in a building by using an elevator. The elevator device includes a control device configured to maintain an evacuation operation mode corresponding to a rescue floor concerned when a car operation instructing device is operated on the rescue floor concerned before a predetermined time passes from when the car stops at the rescue floor concerned during the evacuation operation mode corresponding to the rescue floor concerned, and release the evacuation operation mode corresponding to the rescue floor concerned when the car operation instructing device is not operated on the rescue floor concerned before the predetermined time passes from when the car stops at the rescue floor concerned during the evacuation operation mode corresponding to the rescue floor concerned.

Abstract: An elevator device enabling efficient evacuation of people left in a building is provided. The elevator device includes: an evacuation operation mode request switch provided in a hall of an elevator on a rescue floor; a car that if the evacuation operation mode request switch is kept in an operated state, keeps operating in an evacuation operation mode in which the car moves between the rescue floor and an evacuation floor; and an operation control device that is provided in the hall of the elevator on the rescue floor, and if the operation control device is operated when the car is stopped at the rescue floor, moves the car to the evacuation floor.

Abstract: An elevator device that can continuously evacuate any evacuee left in a building by using an elevator. The elevator device includes a control device configured to maintain an evacuation operation mode corresponding to a rescue floor concerned when a car operation instructing device is operated on the rescue floor concerned before a predetermined time passes from when the car stops at the rescue floor concerned during the evacuation operation mode corresponding to the rescue floor concerned, and release the evacuation operation mode corresponding to the rescue floor concerned when the car operation instructing device is not operated on the rescue floor concerned before the predetermined time passes from when the car stops at the rescue floor concerned during the evacuation operation mode corresponding to the rescue floor concerned.

Abstract: An elevator device enabling efficient evacuation of people left in a building is provided. The elevator device includes: an evacuation operation mode request switch provided in a hall of an elevator on a rescue floor; a car that if the evacuation operation mode request switch is kept in an operated state, keeps operating in an evacuation operation mode in which the car moves between the rescue floor and an evacuation floor; and an operation control device that is provided in the hall of the elevator on the rescue floor, and if the operation control device is operated when the car is stopped at the rescue floor, moves the car to the evacuation floor.

Abstract: In an exemplary embodiment of the present invention, a probe for sampling electromagnetic energy in a circuit is provided. The probe includes a mating portion for mating, in a broadside configuration, with an electromagnetic energy transmission media in the circuit. The probe also includes a correction device for correcting impedance mismatch resulting from mating the mating portion with the electromagnetic energy transmission media of the circuit.

Abstract: In an exemplary embodiment of the present invention, a probe for sampling electromagnetic energy in a circuit is provided. The probe includes a mating portion for mating with a electromagnetic energy transmission media in the circuit. The probe also includes a correction device for correcting impedance mismatch resulting from mating the mating portion with the electromagnetic energy transmission media of the circuit.

Abstract: There is disclosed a tunable notch filter which has a bandpass characteristic and where a tunable notch is added to the bandpass filter by placing a resonator outside the input or output probe of the bandpass filter. The bandpass filter is a resonant type of filter and comprises a plurality of parallel, spaced apart resonators. The tunable notch resonator is positioned near the input or output probe and operates to direct a substantial amount of energy from the filter at the frequency at which the notch resonator is tuned. In this manner a notch is created within the bandpass characteristic of the filter and which notch resonator can be tuned to provide the notch anywhere in the filter passband or above or below the band edges.

Abstract: An equalizer circuit for equalizing RF frequencies implemented as an MMIC or MIC having a series of microstrip transmission lines between an RF input terminal and an RF output terminal and having at least one shunt path comprised of a series combination of a FET able to be switched between a conducting state and a nonconducting state and a stud tuner microstrip transmission line, wherein the FET is used as a voltage variable resistor to selectively de-Q the stub tuner and thereby control the depth of the equalization curve. In a modified embodiment, artificial transmission lines which include a plurality of inductive elements and FETs are coupled to each shunt path, wherein the shunt paths may be selectively shorted by changing the state of the FETs, thereby permitting the center frequency of the equalizer circuit to be shifted as well.

Abstract: A coupled line structure for microwave signals employs a gallium-arsenide substrate having an embedded metallic line located on a surface of the substrate. The surface of the substrate is covered with a thin dielectric layer and at least another metallic line is positioned on the dielectric layer and parallel to the embedded line with a portion of the lines overlapping one another for coupling. A third line can also be disposed on the dielectric layer which line is parallel to the other lines and where the embedded line is connected by a via hole to one of the lines on the dielectric.

Abstract: An FET crossbar switch device is implemented by using a split gate electrode and a shared source and drain pad to implement source and drain electrodes on an integrated circuit substrate. First and second inputs to the device are associated with first and second transmission lines, each of which is directly connected to a first and second source electrode areas. Disposed between the source electrode areas are respective drain electrode sections, each of which is coupled to an associated output transmission line. The input and output transmission lines are fabricated directly on the integrated circuit substrate. Gate fingers or electrodes are directed between respective drain electrodes and adjacent source electrodes. By properly biasing the gate electrodes, one can direct the first input to the first output with the second input directed to the second output. In a second state the first input can be connected to the second output with the second input disconnected or connected to the first output.

Abstract: The present invention is an equalizer circuit for RF frequencies comprising a microstrip transmission line having a stub tuner extending transversely therefrom and further having resistive means coupled to the stub tuner to de-Q the stub tuner, thereby selectively determining an attenuation profile for the equalizer circuit.

Abstract: A broadside microstrip coupler employs a first transmission line which consists of a series of capacitor plates which alternate between a dielectric layer from a first location to a second location and each of the series of plates are connected together with a top plate on the top surface of the dielectric and a bottom plate located a given distance beneath the dielectric layer. A second transmission line alternates between the top and bottom layers of the dielectric and consists of a second series of plates where each capacitor is connected to an adjacent plate with the top plate of the first connecting to the bottom plate of the second and the bottom plate of the first connecting to the top plate of the second and so on. This pattern is repeated so that the conductive plate path alternates from the top to the bottom plate.

Abstract: A broadband microstrip filter structure employs a first transmission line which basically consists of a series of capacitor plates which extend between a dielectric layer from a first location to a second location and each of the series of plates are connected together with a top plate on the top surface of the dielectric and a bottom plate located a given distance beneath the dielectric layer. A second transmission line alternates between the top and bottom layers of the dielectric and consists of a second series of capacitive plates whereby each capacitor is connected to an adjacent capacitor with the top plate of the first connecting to the bottom plate of the second and the bottom plate of the first connecting to the top plate of the second and so on. This pattern is repeated so that the conductor path alternates from the top to the bottom plate. Various capacitors are selected to provide predetermined length resonators while various other capacitors are provided to provide coupling sections.