Patents by Inventor David A. Wink, Jr.

David A. Wink, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
    Patent number: 5840759
    Abstract: The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: November 24, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: James B. Mitchell, Angelo Russo, Murali C. Krishna, David A. Wink, Jr., James E. Liebmann
  • Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents
    Patent number: 5837736
    Abstract: The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: November 17, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: James B. Mitchell, Angelo Russo, Murali C. Krishna, David A. Wink, Jr., James E. Liebmann
  • Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
    Patent number: 5814667
    Abstract: The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: September 29, 1998
    Assignee: United States of America as represented by the Department of Health and Human Services
    Inventors: James B. Mitchell, Angelo Russo, Murali C. Krishna, David A. Wink, Jr., James E. Liebmann
  • Nitric oxide releasing compounds as protective agents in ischemia reperfusion injury
    Patent number: 5789447
    Abstract: The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: August 4, 1998
    Assignees: The United States of America as represented by the Department of Health and Human Services, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: David A. Wink, Jr., James B. Mitchell, Angelo Russo, Murali C. Krishna, Ingeborg Hanbauer, Matthew B. Grisham, Daniel Neil Granger
  • Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
    Patent number: 5650442
    Abstract: The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: July 22, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: James B. Mitchell, Angelo Russo, Murali C. Krishna, David A. Wink, Jr., James E. Liebmann
  • Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents
    Patent number: 5389675
    Abstract: Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is[(M).sub.x.sup.x' (L).sub.y (R.sup.1 R.sup.2 N-N.sub.2 O.sub.2).sub.x ], andK is a pharmaceutically acceptable counterion present in the composition when the overall charge of A is not zero, counterion K being present only in an amount to neutralize A. Methods of treating mammals with such compounds are provided. Pharmaceutical compositions containing such compounds are also provided.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: February 14, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Danae D. Christodoulou, David A. Wink, Jr., Larry K. Keefer