Patents by Inventor David Alexander Rolfe
David Alexander Rolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11986299Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: November 2, 2020Date of Patent: May 21, 2024Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Publication number: 20220280081Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: August 17, 2020Publication date: September 8, 2022Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Publication number: 20210369160Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: April 14, 2021Publication date: December 2, 2021Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Publication number: 20210251540Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: November 2, 2020Publication date: August 19, 2021Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Patent number: 11008627Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: October 16, 2019Date of Patent: May 18, 2021Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Publication number: 20210047678Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: October 16, 2019Publication date: February 18, 2021Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Patent number: 10898895Abstract: This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.Type: GrantFiled: September 13, 2018Date of Patent: January 26, 2021Assignee: Talis Biomedical CorporationInventors: Thomas H. Cauley, III, David Alexander Rolfe, Marc Valer Serra
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Patent number: 10820847Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: October 16, 2019Date of Patent: November 3, 2020Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Publication number: 20200086315Abstract: This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.Type: ApplicationFiled: September 13, 2018Publication date: March 19, 2020Inventors: Thomas H. Cauley, III, David Alexander Rolfe, Marc Valer Serra