Abstract: A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

Abstract: A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

Abstract: The present invention relates to methods of determining the levels of 3-methylhistidine before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in decreasing the levels of 3-methydlhistidine post-prandially and having the beneficial effects as described herein. The pet foodstuff comprises a ratio of protein to fat of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis. The pet foodstuff described is fed to a companion animal for use in reducing and/or preventing sarcopenia. The present invention also relates to methods of feeding the pet foodstuff described and/or dietary regimes to provide the companion animal with the benefit of reducing and/or preventing sarcopenia.

Abstract: A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

Abstract: The present invention relates to methods of determining the levels of endogenous margaric acid before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in increasing the endogenous levels of margaric acid post-prandially and having the beneficial effects as described herein. The pet foodstuff comprises a ratio of protein to fat of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis. The invention also relates to methods of determining levels of lipid metabolites, such as palmitic acid, diacylglycerol (DAG), triacylglycerols (TAGs) and ceramides before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in controlling, regulating and stabilizing lipid metabolites post-prandially to prevent and/or reduce lipotoxicity in the companion animal.

Abstract: A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

Abstract: A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

Abstract: The present invention relates to the use of a diet or foodstuff comprising linoleic acid in an amount ranging from 7 g/Mcal to 9 g/Mcal for sustaining or improving skin quality of a healthy pet. In some embodiments, the diet or foodstuff further comprises zinc in an amount of about 50 mg/Mcal. It further pertains to a diet or foodstuff comprising linoleic acid in an amount ranging from 7 g/Mcal to 9 g/Mcal for use in a method for treating a pet animal affected with a skin disorder or disease.

Abstract: The present invention relates to methods of determining the levels of 3-methylhistidine before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in decreasing the levels of 3-methydlhistidine post-prandially and having the beneficial effects as described herein. The pet foodstuff comprises a ratio of protein to fat of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis. The pet foodstuff described is fed to a companion animal for use in reducing and/or preventing sarcopenia. The present invention also relates to methods of feeding the pet foodstuff described and/or dietary regimes to provide the companion animal with the benefit of reducing and/or preventing sarcopenia.

Abstract: A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

Abstract: A diet composition for an adult dog is provided. The composition comprises a combination of methionine and cysteine or a cysteine providing derivative thereof; wherein methionine is present in a low amount sufficient to deliver between 32.3 and 82.7 mg/Kg metabolic body weight (Kg0.75) when standardized to a 15 Kg dog, and wherein the cysteine or cysteine providing derivative thereof is present in an amount such that the weight ratio of methionine:available cysteine is from 1:0.8 to 1:1.5. The diet may additionally contain other additives such as taurine. Diets of the invention contain sufficient methionine to support metabolism and may prolong lifespan while minimizing the risk of taurine deficiency. Methods for preparing diet compositions of the invention are also described and claimed, as are methods of enhancing longevity and/or treating or preventing dilated cardiomyopathy in dogs.

Abstract: The present invention relates to methods of determining the levels of 3-methylhistidine before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in decreasing the levels of 3-methylhistidine post-prandially and having the beneficial effects as described herein. The pet foodstuff comprises a ratio of protein to fat of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis. The pet foodstuff described is fed to a companion animal for use in reducing and/or preventing sarcopenia. The present invention also relates to methods of feeding the pet foodstuff described and/or dietary regimes to provide the companion animal with the benefit of reducing and/or preventing sarcopenia.

Abstract: The present invention relates to methods of determining the levels of endogenous margaric acid before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in increasing the endogenous levels of margaric acid post-prandially and having the beneficial effects as described herein. The pet foodstuff comprises a ratio of protein to fat of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis. The invention also relates to methods of determining levels of lipid metabolites, such as palmitic acid, diacylglycerol (DAG), triacylglycerols (TAGs) and ceramides before and after a meal in a companion animal, wherein the meal is a pet foodstuff having a particular protein to fat ratio, which is useful in controlling, regulating and stabilizing lipid metabolites post-prandially to prevent and/or reduce lipotoxicity in the companion animal.

Abstract: There is provided a method for searching a database to obtain data. The method includes (a) prioritizing a set of keys that are derived from a match inquiry, thus yielding a prioritized set of keys, wherein the prioritizing is based on, for each key of the set, an efficacy of using the key, (b) determining a subset of the prioritized set, and (c) retrieving, using the subset, a set of candidates for satisfying the match inquiry.

Abstract: There is provided a method for searching a database to obtain data. The method includes (a) prioritizing a set of keys that are derived from a match inquiry, thus yielding a prioritized set of keys, wherein the prioritizing is based on, for each key of the set, an efficacy of using the key, (b) determining a subset of the prioritized set, and (c) retrieving, using the subset, a set of candidates for satisfying the match inquiry.

Abstract: A system and method for finding a business entity in a database that matches input data. A web services interface accepts a match request and provides a best match. A pre-processing layer cleans, parses, and standardizes input data into terms. An application layer includes a match engine for processing the match request using the terms. The match engine evaluates and scores match candidates from the database to provide the best match and, optionally, an ordered list of match candidates.

Abstract: A risk assessment manager is an intranet-based software system that provides enterprise-wide automated risk assessment and portfolio management to help companies reduce bad debt, decrease operational expenses, and increase cash flow. System features include integrating business information associated with unique business identifiers and displaying data in multiple languages and currency.

Abstract: A system and method for finding a business entity in a database that matches input data. A web services interface accepts a match request and provides a best match. A pre-processing layer cleans, parses, and standardizes input data into terms. An application layer includes a match engine for processing the match request using the terms. The match engine evaluates and scores match candidates from the database to provide the best match and, optionally, an ordered list of match candidates.