Patents by Inventor David Allen Annis

David Allen Annis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20100298201
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: November 25, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20100216688
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 22, 2009
    Publication date: August 26, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Llbermann, Tomi K. Sawyer
  • Therapeutic peptidomimetic macrocycles
    Publication number: 20090275519
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: February 9, 2009
    Publication date: November 5, 2009
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
    Patent number: 7449599
    Abstract: The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: November 11, 2008
    Assignee: Merck + Co Inc.
    Inventors: Craig A. Coburn, Thomas G. Steele, Joseph P. Vacca, David Allen Annis, Jr., Gergely M. Makara, Huw M. Nash, Praveen K. Tadikonda, Tong Wang
  • Affinity selection-based screening of hydrophobic proteins
    Publication number: 20020164617
    Abstract: The invention relates to methods based on affinity selection for the identification of ligands for hydrophobic proteins bound by amphiphile. The invention also provides hydrophobic proteins and methods of isolation of hydrophobic proteins that are suitable for ligand screening.
    Type: Application
    Filed: December 19, 2001
    Publication date: November 7, 2002
    Applicant: NeoGenesis Pharmaceuticals, Inc.
    Inventors: Jason S. Felsch, David Allen Annis, Krishna Kalghatgi, Huw M. Nash