Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: A system for making curved cuts of a work piece, the system including a template including a profiled groove spanning from a first end to a second end, the groove dividing the template into distal and proximal halves, at least one profile of a curved cut is part of the groove; a saw including a saw blade; a turntable including a platform and a base upon which the platform is rotatably supported; and a mobility mechanism to which the platform is attached, the mobility mechanism is configured to allow the turntable to traverse between the two ends and a direction transverse to a direction defined by the two ends, wherein the work piece is disposed under the groove of the template and the saw blade is configured to be guided through the groove to cut the work piece according to the at least one profile of a curved cut.

Abstract: A system for making curved cuts of a work piece, the system including a template including a profiled groove spanning from a first end to a second end, the groove dividing the template into distal and proximal halves, at least one profile of a curved cut is part of the groove; a saw including a saw blade; a turntable including a platform and a base upon which the platform is rotatably supported; and a mobility means to which the platform is attached, the mobility means is configured to allow the turntable to traverse between the two ends and a direction transverse to a direction defined by the two ends, wherein the work piece is disposed under the groove of the template and the saw blade is configured to be guided through the groove to cut the work piece according to the at least one profile of a curved cut.