Patents by Inventor David Alvin Tyvoll
David Alvin Tyvoll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230366117Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.Type: ApplicationFiled: March 7, 2023Publication date: November 16, 2023Inventors: David Alvin TYVOLL, Nan CHEN, Bharat Kumar MENON, Heather Michelle GRANDIN, Jenna Brynne LUBET
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Patent number: 11643743Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.Type: GrantFiled: September 13, 2019Date of Patent: May 9, 2023Assignee: ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIAInventors: David Alvin Tyvoll, Bharat Kumar Menon, Nan Chen, Heather Michelle Grandin, Harald Nuhn, Jenna Brynne Lubet
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Patent number: 11608565Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).Type: GrantFiled: December 14, 2021Date of Patent: March 21, 2023Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern CaliforniaInventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
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Publication number: 20220106697Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).Type: ApplicationFiled: December 14, 2021Publication date: April 7, 2022Inventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
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Patent number: 11230787Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).Type: GrantFiled: September 21, 2018Date of Patent: January 25, 2022Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern CaliforniaInventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
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Publication number: 20210238764Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.Type: ApplicationFiled: September 13, 2019Publication date: August 5, 2021Inventors: David Alvin TYVOLL, Bharat Kumar MENON, Nan CHEN, Heather Michelle GRANDIN, Harald NUHN, Jenna Brynne LUBET
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Publication number: 20200240034Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).Type: ApplicationFiled: September 21, 2018Publication date: July 30, 2020Inventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
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Patent number: 10196604Abstract: Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell markers, exemplified by at least one of the genes NANOG, OCT4, and SURVIVIN after periods of culture in ambient oxygen.Type: GrantFiled: June 19, 2015Date of Patent: February 5, 2019Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Regents of the University of Texas SystemInventors: David Alvin Tyvoll, Christopher S. Navara, James P. Collman, Christopher Jeffrey Barile
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Patent number: 9918964Abstract: It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.Type: GrantFiled: April 25, 2011Date of Patent: March 20, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: James P. Collman, Paul Clifford Herrmann, David Alvin Tyvoll, Richard Decreau, Brian Stanley Bull, Christopher Jeffrey Barile
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Publication number: 20170130198Abstract: Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell markers, exemplified by at least one of the genes NANOG, OCT4, and SURVIVIN after periods of culture in ambient oxygen.Type: ApplicationFiled: June 19, 2015Publication date: May 11, 2017Inventors: David Alvin Tyvoll, Christopher S. Navara, James P. Collman, Christopher Jeffrey Barile
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Publication number: 20110301180Abstract: It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.Type: ApplicationFiled: April 25, 2011Publication date: December 8, 2011Applicant: Stanford UniversityInventors: James P. Collman, Paul Clifford Herrmann, David Alvin Tyvoll, Richard Decreau, Brian Stanley Bull, Christopher Jeffrey Barile
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Publication number: 20090010811Abstract: An illumination system enhances a manual human process associated with a multiwell plate having an array of wells thereon. The illumination system includes a compact self-contained apparatus including an illuminator coupled to a human interface. The human interface is configured to receive an operating parameter input and a start input. The illuminator has a protective surface for receiving the well plate and a plurality of underlying light sources configured to initiate a sequence of different well subarray indications in response to the start input and pursuant to the operating parameter input.Type: ApplicationFiled: July 5, 2007Publication date: January 8, 2009Inventors: Richard T. L. Chan, Winston Glenn Walker, David Alvin Tyvoll
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Patent number: 6176908Abstract: Aqueous, fluorescent red ink jet inks which meet US Postal Service requirements for metered mail are disclosed and comprise an aqueous vehicle, a red or magenta pigment, a polymeric dispersant, a fluorescent dye and, optionally a hydrotrope additive.Type: GrantFiled: September 20, 1999Date of Patent: January 23, 2001Assignee: E. I. du Pont de Nemours and CompanyInventors: Richard D. Bauer, John Morrow Gardner, Loretta Ann Grezzo Page, David Alvin Tyvoll