Abstract: The present invention relates to a method of treating or preventing DNA damage in a cell or cellular senescence of a cell or induction of the senescence associated secretory phenotype (SASP) in a cell, or for treating or preventing the effects of aging, or for preventing or treating cellular senescence and/or induction of SASP associated with high caloric intake or obesity, or for reducing the side effects of chemotherapy, radiotherapy, corticoid treatment, anti-retroviral treatment, or PPAR? agonist treatment comprising administering an effective amount of an NAD+ agonist.

Abstract: Method and systems for preparing and analyzing a DNA sample from a subject are provided herein. Also provided are methods and systems for obtaining, analyzing, and manipulating genomic and proteomic sequence data. In particular, methods and systems provided herein involve transformation of raw genetic or proteomic sequence into a compressed data set and transmission of the compressed data set using a fixed binary encoding scheme capable of compressing the data by up to 75%. An interface is in communication with the compression module and configured to display transmitted genomic and proteomic sequence data.

Abstract: The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an agent that elevates SIRTI activity in endothelial cells of the subject, the invention further includes administering an NAD+ agonist or NAD+ precursor to a subject to increase vascular density and/or blood flow. The invention includes compositions comprising the said agent.

Abstract: Systems, devices, and methods for encrypting genetic information are provided herein. Also provided herein are systems, devices, and methods for encrypting compressed genetic data, transmitting encrypted compressed genetic data, and receiving, storing, accessing encrypted compressed genetic data. In some cases, a user interface is in communication with a system or device provided herein.

Abstract: Systems, devices, and methods for encrypting genetic information are provided herein. Also provided herein are systems, devices, and methods for encrypting compressed genetic data, transmitting encrypted compressed genetic data, and receiving, storing, accessing encrypted compressed genetic data.

Abstract: The present invention relates to a method of increasing fertility, or reducing rate of decline in fertility, or restoring fertility, of a female subject, comprising administering to the subject an effective amount of an agent which elevates SIRT2 activity or SIRT2 expression, and to compositions and kits for increasing fertility, or reducing rate of decline in fertility, or restoring fertility.

Abstract: Systems, devices, and methods for encrypting genetic information are provided herein. Also provided herein are systems, devices, and methods for encrypting compressed genetic data, transmitting encrypted compressed genetic data, and receiving, storing, accessing encrypted compressed genetic data. In some cases, a user interface is in communication with a system or device provided herein.

Abstract: A device for compressing subject data, the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Abstract: The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an agent that elevates SIRT1 activity in endothelial cells of the subject, the invention further includes administering an NAD+ agonist or NAD+ precursor to a subject to increase vascular density and/or blood flow. The invention includes compositions comprising the said agent.

Abstract: Systems, devices, and methods for encrypting genetic information are provided herein. Also provided herein are systems, devices, and methods for encrypting compressed genetic data, transmitting encrypted compressed genetic data, and receiving, storing, accessing encrypted compressed genetic data. In some cases, a user interface is in communication with a system or device provided herein.

Abstract: Method and systems for preparing and analyzing a DNA sample from a subject are provided herein. Also provided are methods and systems for obtaining, analyzing, and manipulating genomic and proteomic sequence data. In particular, methods and systems provided herein involve transformation of raw genetic or proteomic sequence into a compressed data set and transmission of the compressed data set using a fixed binary encoding scheme capable of compressing the data by up to 75%. An interface is in communication with the compression module and configured to display transmitted genomic and proteomic sequence data.

Abstract: The technology described in this document can be embodied in a computer-implemented method that includes accessing, by one or more processors, data for a plurality of health-related parameters of an individual, and determining, by the one or more processors, a corresponding individual age-adjustment factor based on data for one or more of the plurality of health-related parameters. The age-adjustment factor computed for a given health-related parameter represents an estimated gain or loss in age as indicated by the data for the given health-related parameter. The method also includes combining, by the one or more processors, two or more of the individual age-adjustment factors to provide a combined age-adjustment factor, and determining, by the one or more processors, a physiological age of the individual based on the combined age-adjustment factor and a chronological age of the individual.

Abstract: A device for compressing subject data, the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Abstract: The present invention relates to a method of treating or preventing DNA damage in a cell or cellular senescence of a cell or induction of the senescence associated secretory phenotype (SASP) in a cell, or for treating or preventing the effects of aging, or for preventing or treating cellular senescence and/or induction of SASP associated with high caloric intake or obesity, or for reducing the side effects of chemotherapy, radiotherapy, corticoid treatment, anti-retroviral treatment, or PPAR? agonist treatment, comprising administering an effective amount of an NAD+ agonist.

Abstract: A technique is provided for classifying images in a library (1) for subsequent selective retrieval. Each library image is segmented (2) into a plurality of coherent regions. Each of the regions is analysed in respect of a plurality of visual properties, each of which is ascribed a number according to the value of the visual property. The property numbers are then compared (4) with bands of the available property range and a computer-readable character, such as a letter of the alphabet, is ascribed to each of the property values. The characters are then arranged (5) in a predetermined order to form a region character string. The strings for each region are then indexed (7) to form an index (8) of the images by region character string. For image retrieval, a target image (10) is analysed in the same way to form region character strings which are then supplied to a text retrieval system (12) for detecting matches with entries in the index (8).

Abstract: A technique is provided for classifying images in a library (1) for subsequent selective retrieval. Each library image is segmented (2) into a plurality of coherent regions. Each of the regions is analysed in respect of a plurality of visual properties, each of which is ascribed a number according to the value of the visual property. The property numbers are then compared (4) with bands of the available property range and a computer-readable character, such as a letter of the alphabet, is ascribed to each of the property values. The characters are then arranged (5) in a predetermined order to form a region character string. The strings for each region are then indexed (7) to form an index (8) of the images by region character string. For image retrieval, a target image (10) is analysed in the same way to form region character strings which are then supplied to a text retrieval system (12) for detecting matches with entries in the index (8).

Abstract: A technique is provided for classifying images in a library (1) for subsequent selective retrieval. Each library image is segmented (2) into a plurality of coherent regions. Each of the regions is analysed in respect of a plurality of visual properties, each of which is ascribed a number according to the value of the visual property. The property numbers are then compared (4) with bands of the available property range and a computer-readable character, such as a letter of the alphabet, is ascribed to each of the property values. The characters are then arranged (5) in a predetermined order to form a region character string. The strings for each region are then indexed (7) to form an index (8) of the images by region character string. For image retrieval, a target image (10) is analysed in the same way to form region character strings which are then supplied to a text retrieval system (12) for detecting matches with entries in the index (8).

Abstract: A technique is provided for classifying images in a library (1) for subsequent selective retrieval. Each library image is segmented (2) into a plurality of coherent regions. Each of the regions is analyzed in respect of a plurality of visual properties, each of which is ascribed a number according to the value of the visual property. The property numbers are then compared (4) with bands of the available property range and a computer-readable character, such as a letter of the alphabet is ascribed to each of the property values. The characters are then arranged (5) in a predetermined order to form a region character string. The strings for each region are then indexed (7) to form an index (8) of the images by region character string. For image retrieval, a target image (10) is analyzed in the same way to form region character strings which are then supplied to a text retrieval system (12) for detecting matches with entries in the index (8).