Patents by Inventor David Augeri

David Augeri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biaryl carboxylic acid apoptosis promoters
    Patent number: 7989656
    Abstract: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: August 2, 2011
    Assignee: Abbott Laboratories
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • APOPTOSIS PROMOTERS
    Publication number: 20100234456
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • Bicyclic modulators of androgen receptor function
    Patent number: 7772267
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 10, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Apoptosis promoters
    Patent number: 7750004
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: July 6, 2010
    Assignee: Abbott Laboratories
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • Bicyclic modulators of androgen receptor function
    Patent number: 7405234
    Abstract: The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: July 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Bicyclic compounds as modulators of androgen receptor function and method
    Patent number: 7388027
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R2? R5, G, n and W are defined herein.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: June 17, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: James J. Li, Lawrence Hamann, David Augeri, Yingzhi Bi
  • OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION
    Publication number: 20080108691
    Abstract: There are provided nuclear hormone receptor modulating compounds of formula I wherein R1, R2, R3, X, Y, n and G are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds. Other embodiments are also disclosed.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Lawrence Hamann, David Augeri, Mark Manfredi
  • BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION
    Publication number: 20080108649
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James Sutton, James Li
  • NOVEL BICYCLIC COMPOUNDS AS MODULATORS OF ANDROGEN RECEPTOR FUNCTION
    Publication number: 20080103188
    Abstract: There are provided bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R2?, R5, G, n and W are defined herein. Other embodiments are also provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 1, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: James LI, Lawrence HAMMANN, David AUGERI, Yingzhi BI
  • Imidazole-based compounds, compositions comprising them and methods of their use
    Publication number: 20070208063
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Application
    Filed: January 25, 2007
    Publication date: September 6, 2007
    Inventors: David Augeri, Jeffrey Bagdanoff, Lakmal Boteju, Kenneth Carson, Theodore Jessop, Spencer Kimball
  • Apoptosis promoters
    Publication number: 20070135392
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Application
    Filed: July 7, 2006
    Publication date: June 14, 2007
    Inventors: Michael Wendt, Hong Ding, Sheela Thomas, Steven Elmore, Wang Shen, Daniel Dickman, David Augeri
  • Aryl pyridines and methods of their use
    Publication number: 20070032501
    Abstract: Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed.
    Type: Application
    Filed: July 31, 2006
    Publication date: February 8, 2007
    Inventors: David Augeri, James Tarver, Qinghong Fu, Michael Voronkov, Doan Hackley, Michael Mertzman, Marianne Carlsen
  • Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor
    Publication number: 20060293229
    Abstract: Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with 13C or 14C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-(nC) butyric acid and 2-keto-3-(nC-methyl)-4-(nC)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.
    Type: Application
    Filed: July 18, 2005
    Publication date: December 28, 2006
    Inventors: Stephen Fesik, David Augeri
  • Bicyclic modulators of androgen receptor function
    Patent number: 6992102
    Abstract: The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: January 31, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence Hamann, David Augeri, Chongqing Sun, Jeffrey A. Robl, Mark E. Salvati, Tammy Wang
  • Novel bicyclic compounds as modulators of androgen receptor function and method
    Publication number: 20050197367
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R2? R5, G, n and W are defined herein.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 8, 2005
    Inventors: James Li, Lawrence Hamann, David Augeri, Yingzhi Bi
  • Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
    Publication number: 20050090539
    Abstract: Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
    Type: Application
    Filed: November 18, 2003
    Publication date: April 28, 2005
    Inventors: Truc Vu, David Brzozowski, Rita Fox, Jollie Godfrey, Ronald Hanson, Sergei Kolotuchin, John Mazzullo, Ramesh Patel, Jianji Wang, Kwok Wong, Jurong Yu, Jason Zhu, David Magnin, David Augeri, Lawrence Hamann
  • Open chain prolyl urea-related modulators of androgen receptor function
    Publication number: 20050059652
    Abstract: The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein R1, R2, R3, X, Y, Z and G are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 13, 2003
    Publication date: March 17, 2005
    Inventors: Lawrence Hamann, David Augeri, Mark Manfredi
  • Bicyclic modulators of androgen receptor function
    Publication number: 20040181064
    Abstract: The invention provides compounds according to formula I 1
    Type: Application
    Filed: February 17, 2004
    Publication date: September 16, 2004
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Bicyclic modulators of androgen receptor function
    Publication number: 20040092559
    Abstract: The invention provides compounds of the formula I 1
    Type: Application
    Filed: October 14, 2003
    Publication date: May 13, 2004
    Inventors: Lawrence Hamann, David Augeri
  • Bicyclic modulators of androgen receptor function
    Publication number: 20040019063
    Abstract: The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I 1
    Type: Application
    Filed: May 15, 2003
    Publication date: January 29, 2004
    Inventors: Chongqing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yanting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins