Patents by Inventor David Austin

David Austin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230321653
    Abstract: Genome whole chromosome analysis is a critical gold standard method for clinicians to study molecular lesions at single cell level in diseases and cancers. However, they suffer from low-sample-yielding, labor-intensive procedures that require subjective manual involvement of highly trained professionals. Here we disclose new devices, systems, and methods to automate, standardize, and accelerate the digital cytopathological sample and data generation with improved data quality to enable precision medicine and improve clinical practice. This disclosure describes a family of micro-fluidic devices, and accompanying methods for using said devices, to perform cytogenomic analysis on cells, nucleus, vesicles exosomes and their respective chromosomes, chromatins, nucleic acid polymers, subcellular genomic elements and any other dynamic transitional states between these forms.
    Type: Application
    Filed: May 28, 2021
    Publication date: October 12, 2023
    Applicants: DIMENSIONGEN, Dimension Genomics Inc
    Inventors: Michael David Austin, Han Cao
  • Patent number: 11777977
    Abstract: A method for establishing a campaign for a simulated phishing attack includes receiving, via a campaign manager, specification of a plurality of parameters for a campaign including at least an identifier of a campaign and identification of users to which to send the campaign, establishing, via the campaign manager, a type of exploit for the campaign and one or more types of data to collect via the type of exploit, storing, by the campaign manager, the campaign comprising the plurality of parameters, and identifying, by a simulation server, the campaign stored in the database to create a simulated phishing email, to be sent to email accounts of the users, using the plurality of parameters of the campaign, wherein the simulated phishing email is to be created to have a link to a landing page comprising the type of exploit and configured to collect the one or more types of data.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: October 3, 2023
    Assignee: KnowBe4, Inc.
    Inventors: Alin Irimie, Wendy Bartlett, David Austin
  • Patent number: 11712966
    Abstract: A circuit breaker for an electric load includes first and second terminals; a number of first separable contacts each electrically connected between one of the first terminals and one of the second terminals; a first mechanism to open, close or trip open the first contacts; a number of second separable contacts each electrically connected in series with a corresponding one of the first contacts; a second mechanism to open or close the second contacts; a processor to cause the second mechanism to open or close the second contacts, annunciate through one of the second terminals a power circuit electrical parameter for the electric load, receive from a number of the second terminals a confirmation from or on behalf of the electric load to cause the second mechanism to close the second contacts, and determine a fault state operatively associated with current flowing through the second contacts.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: August 1, 2023
    Assignee: EATON INTELLIGENT POWER LIMITED
    Inventors: Ronald L. Thompson, Jason-David Nitzberg, David Austin Eldridge, Brandon J. Rogers
  • Publication number: 20230235387
    Abstract: Disclosed are methods for generating physical maps from feature density profiles of a nucleic acid using a constriction device, and associated methods of analyzing said genomic profiles. In addition, disclosed are devices and methods for analyzing secondary, tertiary and quaternary structures on nucleic acids in spatial and temporal context of the 3-D organization of the genome in a constriction or sensor device.
    Type: Application
    Filed: June 28, 2021
    Publication date: July 27, 2023
    Applicants: DIMENSIONGEN, Dimension Genomics Inc.
    Inventors: Michael David Austin, William Ridgeway
  • Publication number: 20230235379
    Abstract: Disclosed herein are methods, compositions and systems for the interrogation of macromolecules, more particularly for preparation of isolated single macromolecules for subsequent processing of specific regions of interest within said macromolecule based on an analysis of the molecule's physical map. The disclosure is further related to the controlled segmentation of long nucleic acid parent molecules into smaller child molecules in a targeted manner such that further processing on said children may be performed with the knowledge of their origin within the parent, in a controlled environment enabled by purposefully designed microfluidic devices. Also disclosed is binding of regional specific barcodes along the length of a long nucleic acid molecule such that upon cleavage of said molecule into child molecules, the regional origin of the children can be tracked, in a controlled environment enabled by purposefully designed microfluidic devices.
    Type: Application
    Filed: April 29, 2021
    Publication date: July 27, 2023
    Applicants: DIMENSIONGEN, Dimension Genomics Inc
    Inventors: Michael David AUSTIN, Han CAO
  • Publication number: 20230224328
    Abstract: Systems and methods are provided for performing simulated phishing attacks using social engineering indicators. One or more failure indicators can be configured in a phishing email template, and each failure indicator can be assigned a description about that failure indicator through use of a markup tag. The phishing email template containing the markup tags corresponding to the failure indicators can be stored and can be used to generate a simulated phishing email in which the one or more markup tags are removed.
    Type: Application
    Filed: March 6, 2023
    Publication date: July 13, 2023
    Applicant: KnowBe4, Inc.
    Inventors: Alin Irimie, Greg Kras, David Austin, Benjamin Dalton
  • Patent number: 11691973
    Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: July 4, 2023
    Assignee: Pfizer Inc.
    Inventors: Shelley Allen, Patrick Michael Doerner Barbour, James Francis Blake, Sydney Taylor Blanche, Mark Laurence Boys, Wesley Dewitt Clark, Connor James Cowdrey, Joshua Ryan Dahlke, Alex Andrew Kellum, Ellen Margaret Knapp, David Austin Moreno, Jacob Matthew O'Leary, Li Ren, Faith Elizabeth Witkos, Jennifer Lynn Fulton
  • Publication number: 20230193382
    Abstract: Disclosed are methods and devices for analyzing the 3D spatial and temporal nucleic acid secondary, tertiary and quaternary structures with a fluorescent interrogation system.
    Type: Application
    Filed: August 9, 2021
    Publication date: June 22, 2023
    Applicants: Dimension Genomics Inc., DIMENSIONGEN
    Inventors: Michael David Austin, William Ridgeway
  • Publication number: 20230142530
    Abstract: A method for ocular simulated camera assisted robot training is provided. In some implementations, the method includes initializing, by a processor, a robotics assembly. The method further includes connecting, by the processor, to one or more computing devices. The method further includes operating, by the processor, the robotics assembly. The method further includes simulating, by the processor, an eye movement of a human or animal. The method further includes operating, by the processor, a laser to perform a determined exercise on an eye of the robotics assembly. Related systems, methods, and articles of manufacture are also described.
    Type: Application
    Filed: August 18, 2022
    Publication date: May 11, 2023
    Inventors: AnnMarie Hipsley, Clemens Roland Hagen, David Austin Neal, James Emmett O'Flanagan
  • Publication number: 20230126737
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Application
    Filed: November 16, 2022
    Publication date: April 27, 2023
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Patent number: 11634409
    Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: April 25, 2023
    Assignee: Array BioPharma Inc.
    Inventors: Patrick Michael Barbour, Katie Keaton Brown, Adam Wade Cook, Erik James Hicken, Dean Russell Kahn, Ellen Ruth Laird, Andrew Terrance Metcalf, David Austin Moreno, Bradley Jon Newhouse, Spencer Phillip Pajk, Brett Joseph Prigaro, Li Ren, Eugene Tarlton
  • Publication number: 20230120188
    Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.
    Type: Application
    Filed: December 1, 2022
    Publication date: April 20, 2023
    Applicant: Pfizer Inc.
    Inventors: Shelley ALLEN, Patrick Michael DOERNER BARBOUR, James Francis BLAKE, Sydney Taylor BLANCHE, Mark Laurence BOYS, Wesley Dewitt CLARK, Connor James COWDREY, Joshua Ryan DAHLKE, Alex Andrew KELLUM, Ellen Margaret KNAPP, David Austin MORENO, Jacob Matthew O'LEARY, Li REN, Faith Elizabeth WITKOS
  • Patent number: 11601470
    Abstract: Systems and methods are provided for performing simulated phishing attacks using social engineering indicators. One or more failure indicators can be configured in a phishing email template, and each failure indicator can be assigned a description about that failure indicator through use of a markup tag. The phishing email template containing the markup tags corresponding to the failure indicators can be stored and can be used to generate a simulated phishing email in which the one or more markup tags are removed.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: March 7, 2023
    Assignee: KnowBe4, Inc.
    Inventors: Alin Irimie, Greg Kras, David Austin, Benjamin Dalton
  • Patent number: 11585921
    Abstract: Provided are a sonar system and transducer assembly for producing a 3D image of an underwater environment. The sonar system may include a housing mountable to a watercraft having a transmit transducer that may transmit sonar pulses into the water. The system may include at least one sidescan transducer array in the housing that receives first and second sonar returns with first and second transducer elements and converts the first and second returns into first and second sonar return data. A sonar signal processor may then generate a 3D mesh data using the first and second sonar return data and at least a predetermined distance between the transducer elements. An associated method of using the sonar system is also provided.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: February 21, 2023
    Assignee: NAVICO HOLDING AS
    Inventors: Alan Lee Proctor, David Austin Parks, Ronald Joe Horner
  • Patent number: 11529630
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: December 20, 2022
    Assignee: Bionano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Publication number: 20220388838
    Abstract: Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices.
    Type: Application
    Filed: March 21, 2022
    Publication date: December 8, 2022
    Inventors: Han Cao, Michael David Austin, Parikshit A. Deshpande, Mark Kunkel, Alexey Y. Sharonov, Michael Kochersperger
  • Publication number: 20220362874
    Abstract: A system and device operating using a welding power bus are provided. One welding power supply includes control circuitry configured to control the operation of the welding power supply and power conversion circuitry configured to convert input power to output welding power. The welding power supply also includes welding terminals configured to receive the output welding power from the power conversion circuitry and to provide the output welding power to a device that does not use the welding power for a welding operation. The control circuitry is configured to adapt the output welding power to the device.
    Type: Application
    Filed: March 7, 2022
    Publication date: November 17, 2022
    Inventors: David Austin Stanzel, Michael William Roth, Anthony VanBergen Salsich, Jeffrey Robert Thomas
  • Publication number: 20220324861
    Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.
    Type: Application
    Filed: March 30, 2022
    Publication date: October 13, 2022
    Applicant: Pfizer Inc.
    Inventors: Shelley ALLEN, Patrick Michael DOERNER BARBOUR, James Francis BLAKE, Sydney Taylor BLANCHE, Mark Laurence BOYS, Wesley Dewitt CLARK, Connor James COWDREY, Joshua Ryan DAHLKE, Alex Andrew KELLUM, Ellen Margaret KNAPP, David Austin MORENO, Jacob Matthew O'LEARY, Li REN, Faith Elizabeth WITKOS
  • Publication number: 20220289721
    Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
    Type: Application
    Filed: May 16, 2022
    Publication date: September 15, 2022
    Applicant: Array BioPharma Inc.
    Inventors: Patrick Michael BARBOUR, Katie Keaton BROWN, Adam Wade COOK, Erik James HICKEN, Dean Russell KAHN, Ellen Ruth LAIRD, Andrew Terrance METCALF, David Austin MORENO, Bradley Jon NEWHOUSE, Spencer Phillip PAJK, Brett Joseph PRIGARO, Li REN, Eugene TARLTON
  • Publication number: 20220288074
    Abstract: Provided herein is a compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 15, 2022
    Applicant: Array BioPharma Inc.
    Inventors: Patrick Michael DOERNER BARBOUR, Tanna Marie BETTENDORF, Dean Russell KAHN, Alex Andrew KELLUM, Ellen Ruth LAIRD, David Austin MORENO, Li REN