Abstract: Systems, devices, apparatuses and automated methods are described for tracking and verification of medications and chain of custody. The described technology enables prescription medications and samples to be tracked across supply chains during which the medications and samples may be verified for integrity and proper chain of custody. The described technology also enables prescription medications and samples to be identified by verified location and by unique alphanumeric codes, as well as by secure custodian identifiers, to verify proper tracking and transparent chain of custody. The described technology further provides for secure custody transfers and pedigree assurance for prescription medications and samples.