Abstract: Provided herein are compositions and methods for treating and preventing bacterial infections. In particular, provided herein are targeted bola-amphiphile: nucleic acid complexes specific for bacteria.

Abstract: Defibrillators with enhanced functionality during cardiopulmonary resuscitation (CPR) periods are described. The enhancements include predicting a length of a charging period of a capacitor of the medical device so that capacitor is shock charged at the end of the CPR period. The enhancements also include re-assessing an electrocardiogram (ECG) signal for continued presence of a shockable rhythm during the CPR period and before administration of a defibrillation shock. Together the enhancements can improve the timing and recommended administration of defibrillation therapy.

Abstract: Systems and techniques to ensure reliable operation of devices, such as medical devices, that are configured to execute installed software are described. A secure software update process for the device utilizes multiple integrity checks in order to prove that software integrity has not been compromised before the device is allowed to be put into service with the software installed thereon. Also described is a computer architecture for an external defibrillator that isolates the execution of installed software applications by separately compiling the code for those applications and by executing the separately-compiled applications on different processors of the defibrillator. Among other things, this allows the defibrillator to be “brought online” faster, such as to deliver a shock to a patient.

Abstract: Apparatus attached to the flared open end of a wind instrument includes one or more layers of particle filtering materials for preventing the dispersion of pathogens from the wind instrument while enabling sound transmission with little muffling and distortion, and minimal resistance for the musician.

Abstract: A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions.

Abstract: An adaptable healthcare module that is coupleable to one or more defibrillator devices is disclosed. The adaptable health care module includes a healthcare coupling to assist with treatment and/or monitoring of a patient. The healthcare coupling can be active while decoupling the adaptable healthcare module from a first defibrillator device and coupling to a second defibrillator device. The coupling of the adaptable healthcare module includes a mechanical engagement, between the adaptable healthcare module and the defibrillator device, to retain the adaptable healthcare module to the defibrillator device.

Abstract: A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions.

Abstract: A defibrillator is provided with two processors for enhancing the defibrillation process. A first processor is dedicated to controlling when an electrical charge is applied to a patient. A second processor is dedicated to data operations for enhancing the coaching of the defibrillation process. The second data processor is in communication with one or more external devices for transmission and receipt of network data for further enhancing the coaching process. The second data processor allows both the defibrillator to be maintained with updated network data and software and the one or more external devices to be maintained with updated defibrillator data. Independent controllers provide multiple processing paths on critical charge and coaching functions; with the second data processor further providing redundancy control in the event of any malfunction of the first charge processor.

Abstract: A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions.

Abstract: A wave energy converter (WEC) buoy includes at least one pitch-driven WEC (“PDWEC”) device. Each PDWEC device includes two reaction masses which are placed at diametrically opposite ends of a container designed to float along the surface of a body of water and to move in response to the pitching motion of the waves. The reaction masses are interconnected so that when one reaction mass moves up, the diametrically opposed reaction mass moves down, and vice-versa. The movement of the reaction masses drives power take off (PTO) devices to produce useful energy. The reaction masses may be interconnected by any suitable linking system. One or more PDWEC device may be combined with a heave responsive device to produce a WEC buoy which can produce a power output in response to pitch or heave motion.

Abstract: A decision support definitions library stores one or more decision support definitions for providing appropriate treatment paths. A device management library stores device and configuration setting information on one or more devices associated with an organization, the configuration setting including information on smart agents residing on the one or more devices. A decision support definition editor is configured to modify a selected one or more decision support definitions and one or more device and configuration settings. A decision support definition generator is configured to create an installation configuration file including an entry for each of a selected one or more decision support definitions, wherein each entry comprises: (i) information that identifies the respective decision support definition, (ii) configuration information, and (iii) information that identifies an installation program.

Abstract: In embodiments, an emergency external defibrillator system is configured for use by a local rescuer in cooperation with a remote rescuer to assist a patient. The external defibrillator system includes a sensor to generate a patient value that represents a physiological parameter of the patient. The system also includes a communication module to transmit the patient value to another device of a remote rescuer, and to receive in response an incoming message that contains an encoded discharge instruction. The system also includes a processor that can decode the discharge instruction, and cause the system to defibrillate or pace the patient. An advantage is that therapy can be initiated remotely from the remote rescuer, who may be better trained, more confident, and less under the stress of the moment than the local rescuer.

Abstract: Technologies and implementations for a universally adaptable module for defibrillator monitors are generally disclosed.

Abstract: In embodiments, an emergency external defibrillator system is configured for use by a local rescuer in cooperation with a remote rescuer to assist a patient. The external defibrillator system includes a sensor to generate a patient value that represents a physiological parameter of the patient. The system also includes a communication module to transmit the patient value to another device of a remote rescuer, and to receive in response an incoming message that contains an encoded discharge instruction. The system also includes a processor that can decode the discharge instruction, and cause the system to defibrillate or pace the patient. An advantage is that therapy can be initiated remotely from the remote rescuer, who may be better trained, more confident, and less under the stress of the moment than the local rescuer.

Abstract: In embodiments, an emergency external defibrillator system is configured for use by a local rescuer in cooperation with a remote rescuer to assist a patient. The external defibrillator system includes a sensor to generate a patient value that represents a physiological parameter of the patient. The system also includes a communication module to transmit the patient value to another device of a remote rescuer, and to receive in response an incoming message that contains an encoded sound. For the local rescuer, the system also includes a screen to display the patient value, and a speaker to play the sound concurrently with the screen displaying the patient value. An advantage is that the local rescuer can receive guidance from the remote rescuer.

Abstract: A defibrillator is provided with two processors for enhancing the defibrillation process. A first processor is dedicated to controlling when an electrical charge is applied to a patient. A second processor is dedicated to data operations for enhancing the coaching of the defibrillation process. The second data processor is in communication with one or more external devices for transmission and receipt of network data for further enhancing the coaching process. The second data processor allows both the defibrillator to be maintained with updated network data and software and the one or more external devices to be maintained with updated defibrillator data. Independent controllers provide multiple processing paths on critical charge and coaching functions; with the second data processor further providing redundancy control in the event of any malfunction of the first charge processor.

Abstract: In embodiments, an emergency external defibrillator system is configured for use by a local rescuer in cooperation with a remote rescuer to assist a patient. The external defibrillator system includes a sensor to generate a patient value that represents a physiological parameter of the patient. The system also includes a communication module to transmit the patient value to another device of a remote rescuer, and to receive in response an incoming message that contains an encoded sound. For the local rescuer, the system also includes a screen to display the patient value, and a speaker to play the sound concurrently with the screen displaying the patient value. An advantage is that the local rescuer can receive guidance from the remote rescuer.

Abstract: A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions.

Abstract: The generally up and down movement of a reaction mass is converted into rotary motion which is used to drive a rotary hydraulic spring comprised of a rotary hydraulic pump motor and an accumulator to produce a “spring” function. The invention is particularly applicable to wave energy converters (WECs) having a reaction mass which needs to be coupled to a spring to ensure its oscillation and to cause it to be centered about its center of travel. The linear up-down motion of a reaction mass may be converted via a linear-to-rotary translator to rotary motion to drive a rotary hydraulic pump/motor so as to provide spring action to the reaction mass and ensure its oscillation and proper positioning.

Abstract: Apparatus for connecting a power cable to a marine vessel which is subject to pitch, heave, roll and yaw motion includes a ball and socket device for decreasing the twisting and bending of the power cable. The socket is attached to the vessel and the ball can rotate freely Within the socket but its up down motion is restricted. The power cable's outer protective sheath is attached to the ball while its conductors pass through the ball and are connected to an internal connector. A flexible cable (wire) is connected between the internal connector and electrical equipment internal to the marine vessel.