Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A method comprises displaying visual representations of a plurality of product alternatives each including at least one attribute variant to a respondent, receiving from the respondent an indication of a preferred one of the plurality of product alternatives, transmitting a request to the respondent to identify at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives and receiving a response from the respondent identifying at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives.

Abstract: A method comprises displaying visual representations of a plurality of product alternatives each including at least one attribute variant to a respondent, receiving from the respondent an indication of a preferred one of the plurality of product alternatives, transmitting a request to the respondent to identify at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives and receiving a response from the respondent identifying at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives.

Abstract: A method comprises displaying visual representations of a plurality of product alternatives each including at least one attribute variant to a respondent, receiving from the respondent an indication of a preferred one of the plurality of product alternatives, transmitting a request to the respondent to identify at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives and receiving a response from the respondent identifying at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives.

Abstract: A method comprises displaying visual representations of a plurality of product alternatives each including at least one attribute variant to a respondent, receiving from the respondent an indication of a preferred one of the plurality of product alternatives, transmitting a request to the respondent to identify at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives and receiving a response from the respondent identifying at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives.

Abstract: A method comprises displaying visual representations of a plurality of product alternatives each including at least one attribute variant to a respondent, receiving from the respondent an indication of a preferred one of the plurality of product alternatives, transmitting a request to the respondent to identify at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives and receiving a response from the respondent identifying at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives.

Abstract: A method comprises displaying visual representations of a plurality of product alternatives each including at least one attribute variant to a respondent, receiving from the respondent an indication of a preferred one of the plurality of product alternatives, transmitting a request to the respondent to identify at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives and receiving a response from the respondent identifying at least one attribute variant of a non-preferred product alternative that is preferred by the respondent to the corresponding attribute variant of the preferred one of the plurality of product alternatives.

Abstract: A method, computer program product, and computer system for receiving, at a computing device, data from at least one user, wherein at least a portion of the data is associated with the plurality of attribute variants. A variant relationship between one or more pairs of attribute variants of the plurality of attribute variants is determined based upon, at least in part, at least the portion of the data. The distance between the one or more pairs of objects is adjusted based upon, at least in part, the variant relationship between the one or more pairs of attribute variants of the plurality of attribute variants.

Abstract: Disclosed are methods and apparatus for conducting market research and developing product designs. The methods involve generating and presenting, typically electronically, generations of design alternatives to persons participating in the design, selection, or market research exercise. The participants transmit data indicative of their preferences among or between the presented design alternatives. Some of the data is used to conduct a conjoint analysis or non-convergent exercise to investigate the drivers of the preferences of the group or its members, and at least a portion are used to derive follow-on generations of design alternatives or proposals. The follow-on designs are preferably generated through the use of an evolutionary or genetic computer program, influenced by the participants' preferences.