Patents by Inventor David B. Weiner

David B. Weiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAYARO VIRUS CONSENSUS ANTIGENS, DNA ANTIBODY CONSTRUCTS FOR USE AGAINST MAYARO VIRUS, AND COMBINATIONS THEREOF
    Publication number: 20200237895
    Abstract: Disclosed herein is a composition comprising a nucleic acid sequence encoding a Mayaro Virus antigen that elicits an immune response in a mammal. Also disclosed herein is a nucleic acid sequence encoding an anti-Mayaro Virus antibody, a fragment thereof, a variant thereof. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Mayaro virus infection in a subject using said composition and method of generation.
    Type: Application
    Filed: October 12, 2018
    Publication date: July 30, 2020
    Inventors: David B. Weiner, Kar Muthumani, Sagar Kudchodkar
  • DTERT VACCINES AND METHODS OF TREATMENT USING THE SAME
    Publication number: 20200147195
    Abstract: Disclosed herein are compositions and methods for treating and/or preventing cancer in dogs, and in particular, vaccines that treat and provide protection against tumor growth.
    Type: Application
    Filed: May 24, 2018
    Publication date: May 14, 2020
    Inventors: Kar Muthumani, David B. Weiner
  • Vaccines and immunotherapeutics using IL-28 and compositions and methods of using
    Patent number: 10646563
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Matthew Morrow
  • Foot and Mouth Disease Virus (FMDV) Consensus Proteins, Coding Sequences Therefor and Vaccines Made Therefrom
    Publication number: 20200017553
    Abstract: Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
    Type: Application
    Filed: May 20, 2019
    Publication date: January 16, 2020
    Inventors: David B. Weiner, Bernadette Ferraro, Jian Yan, Patricia A. Brown, Rodney A. Bowling, Douglas R. Kern, Mathura P. Ramanathan, Niranjan Y. Sardesai, Karuppiah Muthumani
  • FOOT AND MOUTH DISEASE VIRUS SEROTYPE O (FMDV-O) VACCINE
    Publication number: 20190275138
    Abstract: The present invention relates to synthetic, consensus foot-and-mouth disease virus serotype O (FMDV-O) immunogenic proteins and nucleic acid molecule encoding such proteins and to methods for inducing immune responses against FMVD-O.
    Type: Application
    Filed: November 22, 2017
    Publication date: September 12, 2019
    Inventors: David B. Weiner, Kar Muthumani
  • Influenza nucleic acid molecules and vaccines made therefrom
    Patent number: 10398769
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA Influenza A of serotype H7N9 alone and in combination with HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: September 3, 2019
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David B. Weiner, Jian Yan
  • WT1 Vaccine
    Publication number: 20190255163
    Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.
    Type: Application
    Filed: December 17, 2018
    Publication date: August 22, 2019
    Inventors: David B. Weiner, Jian Yan, Jewell Walters
  • SYNTHETIC IMMUNOGENS FOR PROPHYLAXIS OR TREATMENT OF TUBERCULOSIS
    Publication number: 20190240307
    Abstract: Compositions comprising a nucleic acid molecule that encodes TB esat-6 proteins are disclosed. Methods of inducing an immune response against TB an individual are disclosed. Method of treating an individual who has been diagnosed with TB are disclosed. Method of preventing TB infection in an individual are disclosed.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 8, 2019
    Inventors: David B. Weiner, Daniel Villarreal
  • Influenza nucleic acid molecules and vaccines therefrom
    Patent number: 10363302
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotpyes using the vaccines that are provided.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: July 30, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Matthew P. Morrow, Jian Yan
  • DNA Monoclonal Antibodies Targeting IL-6 and CD126
    Publication number: 20190192692
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-IL-6 and/or anti-CD 126 synthetic antibody. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: May 5, 2017
    Publication date: June 27, 2019
    Inventors: David B. Weiner, Sarah Elliott
  • Filovirus Consensus Antigens, Nucleic Acid Constructs and Vaccines Made Therefrom, and Methods of Using Same
    Publication number: 20190153040
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 23, 2019
    Inventors: David B. Weiner, Ami Patel, Jian Yan
  • Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
    Patent number: 10294278
    Abstract: Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: May 21, 2019
    Inventors: David B. Weiner, Bernadette Ferraro, Jian Yan, Patricia A. Brown, Rodney A. Bowling, Douglas R. Kern, Mathura P. Ramanathan, Niranjan Y. Sardesai, Karuppiah Muthumani
  • DNA Monoclonal Antibodies Targeting Checkpoint Molecules
    Publication number: 20190142920
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 16, 2019
    Inventors: David B. Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • VACCINES WITH BIOMOLECULAR ADJUVANTS
    Publication number: 20190142937
    Abstract: Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 16, 2019
    Inventors: David B. Weiner, Karuppiah Muthumani
  • DNA Monoclonal Antibodies Targeting Influenza Virus
    Publication number: 20190135899
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 9, 2019
    Inventors: David B. Weiner, Ami Patel, Jian Yan, Sarah Elliott
  • DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
    Publication number: 20190091322
    Abstract: Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.
    Type: Application
    Filed: March 21, 2017
    Publication date: March 28, 2019
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai, Sarah Elliott, Jian Yan, Ami Patel
  • Vaccines for human papilloma virus and methods for using the same
    Patent number: 10232030
    Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV6 E6E7, HPV11 E6E7, HPV16 E6E7, HPV18 E6E7, HPV31 E6E7, HPV33 E6E7, HPV39 E6E7, HPV45 E6E7, HPV52 E6E7, and HPV58 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 19, 2019
    Assignees: INOVIO PHARMACEUTICALS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Jian Yan
  • VACCINES AND IMMUNOTHERAPEUTICS USING IL-28 AND COMPOSITIONS AND METHODS OF USING
    Publication number: 20190076520
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: David B. Weiner, Matthew Morrow
  • Vaccines with biomolecular adjuvants
    Patent number: 10226528
    Abstract: Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 12, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Karuppiah Muthumani
  • WT1 vaccine
    Patent number: 10220082
    Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: March 5, 2019
    Assignees: INOVIO PHARMACEUTICALS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Jian Yan, Jewell Walters