Abstract: The present disclosure provides novel and efficient methods and lentiviral vectors for manufacturing a population of immune cells engineered to express a Chimeric Antigen Receptor (CAR), an engineered T cell receptor (TCR), and/or a nucleic acid sequence encoding a polypeptide that enhances the immune cell function, or a functional derivative thereof in less than 72 hours; engineered cells generated by the methods, compositions comprising said cells and methods of treating a disease or condition using said cells.

Abstract: The disclosure relates to immune cells comprising one or more vectors comprising a nucleic acid sequence encoding a chimeric antigen receptor specific for CD19 and a nucleic acid sequence encoding an enhancer of T cell priming (e.g., IL-18), compositions comprising the T cells, and methods of generating and/or using the T cells to treat diseases associated with the expression of CD19.

Abstract: The disclosure relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain.

Abstract: An apparatus includes first and second pluralities of switches, a controller for controlling these switches, gate-drivers for driving switches from the first plurality of switches, and first and second terminals configured for coupling to corresponding first and second external circuits at corresponding first and second voltages. During operation, the controller causes the first plurality of switches to transition between states. These transitions result in the second voltage being maintained at a value that is a multiple of the first voltage. The controller also causes the second plurality of switches to transition between states. These transitions resulting in capacitors being coupled or decoupled from the second voltage. The gate drivers derive, from the capacitors, charge for causing a voltage that enables switches from the first plurality of switches to be driven.

Abstract: A computing device includes: a housing supporting a transparent panel to define an enclosure; a camera supported within the enclosure, the camera having a field of view extending through the transparent panel; and a privacy shutter supported within the enclosure, between the transparent panel and the camera, the privacy shutter having a shutter magnet, and being movable via magnetic activation between (i) an enabled position obstructing the field of view, and (ii) a disabled position clearing the field of view.

Abstract: A dock for a computing device includes: a cradle configured to receive a first edge of the computing device; a body extending from the cradle, the body having: (i) a first mounting surface configured to removably support a first accessory module in a first volume adjacent to the computing device, and (ii) a second mounting surface configured to removably support, independently of the first accessory module, a second accessory module in a second volume disjoint from the first volume.

Abstract: Disclosed herein is a system and method for managing financial information. According to an embodiment, electronic purchase data is received from an electronic payment source. The received electronic purchase data is generated into one or more visual representation formats using a transformation server. Once the visual representation has been generated, the visual representation format is rendered using a display device.

Abstract: A drill rig having a longitudinal drilling axis, a front portion, and a rear portion can comprise a feedframe aligned with the longitudinal drilling axis, a first head assembly coupled to the feedframe and configured to rotate a drill string, and a rod holder proximate the front portion of the drill rig. A second head assembly can be movable on the feedframe along the longitudinal axis and can include a powered water swivel assembly comprising a spindle having an interior bore a drill rod connector at a first end of the spindle, a motor that is configured to rotate the spindle, a clutch configured to disengage the motor from the spindle, a gearbox that couples the motor to the spindle, and a water swivel that is configured to provide drilling fluid to the interior bore of the spindle.

Abstract: The present invention provides gene edited modified immune cells suitable for adoptive T cell therapy comprising a nucleic acid capable of downregulating CD3?, CD3?, CD3?, B2M, CIITA, TAP1, TAP2, TAPBP, NLRC5, HLA-DM, RFX5, RFXANK, RFXAP, and invariant chain; and further comprising an exogenous nucleic acid encoding a chimeric antigen receptor (CAR), an engineered T cell receptor (TCR), a Killer cell immunoglobulin-like receptor (KIR), dominant negative receptor and/or a switch receptor. Also provided are compositions and methods for generating the modified immune cell, and methods of using the modified immune cells for adoptive therapy and treating a disease or condition.

Abstract: This invention is an apparatus that can be intermittently bottom moored and moved with buoyancy as it uses its sensors to collect data in deep ocean water. In one embodiment of the invention, the apparatus includes one or more floats, buoyancy engines, payload sensors, depth sensors and electronics. The electronics provide the power and, among other things, control the transmission of data from and the reception of information by the apparatus. An anchor is used to moor the apparatus at desired locations. When not moored, the apparatus drifts with the currents at the depth at which the apparatus is then positioned, with the movement being directed by current flow of the water. The movement of the apparatus is guided with knowledge of the currents and tides (it is not random).

Abstract: An oral hygiene device is provided. The oral hygiene device includes a body having a base and first and second opposing sides extending from the base and defining a gap there between. The device may further include a plurality of corresponding notch pairs, wherein each corresponding notch pair has a first notch positioned in the first opposing side and a second notch positioned in the second opposing side. The location of the notch pairs may coincide with a user's mouth and in particular to the position of the user's teeth within the mouth. As such, a fibrous material, such as floss, may be coupled to the device such that the material spans the gap between at least one of the corresponding notch pairs so that the material may be inserted into the spaces between the user's teeth when the device is placed into the user's mouth.

Abstract: The present disclosure is directed to chimeric antigen receptors binding to Glypican 2, nucleic acids encoding the same, and cells expressing the same, and methods of using such cells to treat cancers that express or overexpress the Glypican 2 antigen.

Abstract: A drill rig having a longitudinal drilling axis, a front portion, and a rear portion can comprise a feedframe aligned with the longitudinal drilling axis, a first head assembly coupled to the feedframe and configured to rotate a drill string, and a rod holder proximate the front portion of the drill rig. A second head assembly can be movable on the feedframe along the longitudinal axis and can include a powered water swivel assembly comprising a spindle having an interior bore a drill rod connector at a first end of the spindle, a motor that is configured to rotate the spindle, a clutch configured to disengage the motor from the spindle, a gearbox that couples the motor to the spindle, and a water swivel that is configured to provide drilling fluid to the interior bore of the spindle.

Abstract: A method of selecting wavelengths of radiation for discriminating a first cell or tissue type from a different cell or tissue type is described. First and second sets of absorption spectra are obtained, each set comprising spectra obtained at a plurality of different spatial regions of the first cell or tissue type and of the different cell or tissue type, respectively. Sets of corresponding metrics are defined for the first and second sets of absorption spectra for each spatial region. Each metric comprises information corresponding to the absorption for at least two different wavelengths. The metrics in each set comprise different combinations of wavelengths. A characteristic value is generated for each metric. Distributions are generated for each metric using corresponding characteristic values for the first cell or tissue type and for the different cell or tissue type and compared to determine an extent of similarity.

Abstract: A bi-directional egress hatch for a passenger aircraft may allow passengers to rapidly and safely exit an overhead cabin of the aircraft onto the main deck, while allowing cabin crew to safely ascend into the overhead cabin if need be. Hatch panels may blend in with overhead bin doors and ceiling panels of the main cabin; the inner portions of the hatch panels (facing the overhead cabin) may include anti-skid portions and graspable handles for descending passengers. The hatch may be easily activated by a passenger with a single motion (or remotely activated, or autodeployed). Once activated, the hatch panels may swing open and a telescoping ladder may deploy from the inner portion to the main deck, remaining rigid once reaching the floor. Similarly, any barriers protecting the ladder from passengers in the overhead cabin may be released, granting access to the telescoping ladder.

Abstract: The present disclosure provides improved compositions and methods for T-cell-based immunotherapy employing a modified T cells obtained from the lymphatic system of normal and cancer patient donors. These cells can then be used to treat patients for a variety of different blood and solid tumor cancers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network having a plurality of network parameters and being configured to process an input data item to generate a feature representation comprising a values for each of a plurality of features of the input data item.

Abstract: A method of selecting wavelengths of radiation for discriminating a first cell or tissue type from a different cell or tissue type is described. First and second sets of absorption spectra are obtained, each set comprising spectra obtained at a plurality of different spatial regions of the first cell or tissue type and of the different cell or tissue type, respectively. Sets of corresponding metrics are defined for the first and second sets of absorption spectra for each spatial region. Each metric comprises information corresponding to the absorption for at least two different wavelengths. The metrics in each set comprise different combinations of wavelengths. A characteristic value is generated for each metric. Distributions are generated for each metric using corresponding characteristic values for the first cell or tissue type and for the different cell or tissue type and compared to determine an extent of similarity.

Abstract: Passenger rest compartments may be incorporated into remote areas of an aircraft, either in the overhead crown region or in lower lobe cargo decks. Each passenger rest compartment includes two-way audio communication with the flight deck and non-intrusive non-visual monitoring of the compartments and surrounding environment to determine passenger presence, absence, and general well-being as well as environmental safety. Rest compartments may be integrated into rest cabins in the overhead or lower lobe areas, the rest cabins accessible from the main passenger cabin via an entry vestibule providing dedicated enclosed paths to the overhead and lower cabins. Additional deployable egress hatches may allow passengers to rapidly return to the main deck from the overhead and lower lobe cabins in the event of an emergency. Selected passenger seats (e.g., partitioned or other premium seats) may include private access to passenger rest compartments.

Abstract: An oral hygiene device is provided. The oral hygiene device includes a body having a base and first and second opposing sides extending from the base and defining a gap there between. The device may further include a plurality of corresponding notch pairs, wherein each corresponding notch pair has a first notch positioned in the first opposing side and a second notch positioned in the second opposing side. The location of the notch pairs may coincide with a user's mouth and in particular to the position of the user's teeth within the mouth. As such, a fibrous material, such as floss, may be coupled to the device such that the material spans the gap between at least one of the corresponding notch pairs so that the material may be inserted into the spaces between the user's teeth when the device is placed into the user's mouth.