Abstract: This invention relates to a method of treating damage to the central nervous system, comprising administering a pharmaceutically-effective amount of a CCR5 antagonist, and a pharmaceutically effective amount of an AQP4 antagonist, or pharmaceutically acceptable salts thereof.

Abstract: Apparatuses, systems, and techniques to perform and facilitate flight system compliance analysis. In at least one embodiment, one or more processors and/or computing systems compute one or more metrics to model and analyze performance of one or more aircraft systems with respect to one or more safety requirements.

Abstract: An injection-device and an injection-measuring method are described. The injection-device includes a pen-type sleeve for accommodating a cartridge holder, a mechanical injection system provided in the pen-type sleeve, which has a dosing sleeve by which a dosage quantity to be injected is predefinable and which is configured to execute a rotatory motion during the injection process; a selector device, connected to the dosing sleeve, for adjusting the dosage quantity to be injected; an injection button, connected to the selector device, for applying an injection force; and an optical sensor device for detecting the rotatory motion of the dosage sleeve during injection of the dosage quantity, which has a signal-processing device for ascertaining and storing the injected dosage quantity based on the detected rotatory motion of the dosage sleeve. The injection button has a switch device by which the optical sensor device is activatable when applying the injection force.

Abstract: In some implementations, a system is capable of obtaining and processing both actively monitored and passively monitored data in parallel in order to improve the accuracy and the specificity by which pathological risks are identified for a user. Data indicating measured levels of one or more metabolic biomarkers and activity data associated with a user is obtained. A biological state for the user is determined based on the measured levels of the one or more metabolic biomarkers. One or more user inputs indicated within the activity data, and scores reflecting respective likelihoods that a particular user input indicates a change to one or more aspects of the biological state for the user for each of the one or more user inputs is determined. Data corresponding to the biological state for the user is then adjusted. A communication that is generated based on the adjusted data is then provided for output.

Abstract: An injection-device and an injection-measuring method are described. The injection-device includes a pen-type sleeve for accommodating a cartridge holder, a mechanical injection system provided in the pen-type sleeve, which has a dosing sleeve by which a dosage quantity to be injected is predefinable and which is configured to execute a rotatory motion during the injection process; a selector device, connected to the dosing sleeve, for adjusting the dosage quantity to be injected; an injection button, connected to the selector device, for applying an injection force; and an optical sensor device for detecting the rotatory motion of the dosage sleeve during injection of the dosage quantity, which has a signal-processing device for ascertaining and storing the injected dosage quantity based on the detected rotatory motion of the dosage sleeve. The injection button has a switch device by which the optical sensor device is activatable when applying the injection force.

Abstract: In some implementations, a system is capable of obtaining and processing both actively monitored and passively monitored data in parallel in order to improve the accuracy and the specificity by which pathological risks are identified for a user. Data indicating measured levels of one or more metabolic biomarkers and activity data associated with a user is obtained. A biological state for the user is determined based on the measured levels of the one or more metabolic biomarkers. One or more user inputs indicated within the activity data, and scores reflecting respective likelihoods that a particular user input indicates a change to one or more aspects of the biological state for the user for each of the one or more user inputs is determined. Data corresponding to the biological state for the user is then adjusted. A communication that is generated based on the adjusted data is then provided for output.

Abstract: In some implementations, a system is capable of obtaining and processing both actively monitored and passively monitored data in parallel in order to improve the accuracy and the specificity by which pathological risks are identified for a user. Data indicating measured levels of one or more metabolic biomarkers and activity data associated with a user is obtained. A biological state for the user is determined based on the measured levels of the one or more metabolic biomarkers. One or more user inputs indicated within the activity data, and scores reflecting respective likelihoods that a particular user input indicates a change to one or more aspects of the biological state for the user for each of the one or more user inputs is determined. Data corresponding to the biological state for the user is then adjusted. A communication that is generated based on the adjusted data is then provided for output.

Abstract: A child resistant blister pack includes a blister layer which includes one or more blister cavities for receiving a product. A frangible retaining layer is attached to the blister layer over the blister cavities to retain the product within the blister cavities. A first backing layer is attached to the retaining layer on a side opposite the blister layer. The first backing layer has one or more lines of weakness aligned with the blister cavities. A second backing layer is attached to the first backing layer on a side opposite the retaining layer. The second backing layer has a plurality of removable sections. At least two removable sections are arranged over each line of weakness in the underlying first backing layer.

Abstract: A child resistant blister pack includes a blister layer which includes one or more blister cavities for receiving a product. A frangible retaining layer is attached to the blister layer over the blister cavities to retain the product within the blister cavities. A first backing layer is attached to the retaining layer on a side opposite the blister layer. The first backing layer has one or more lines of weakness aligned with the blister cavities. A second backing layer is attached to the first backing layer on a side opposite the retaining layer. The second backing layer has a plurality of removable sections. At least two removable sections are arranged over each line of weakness in the underlying first backing layer.

Abstract: In order to increase the efficacy of a mood-based playlisting system, a mood sensor such as a camera may be used to provide mood information to the mood model. When the mood sensor includes a camera, a camera may be used to capture an image of the user. The image is analyzed to determine a mood for the user so that content may be selected responsive to the mood of the user.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: A switch having a first communications interface to receive a stream of data units, a buffer to store the payload portion of the data unit, a replicator to duplicate at least the payload portion of the data unit, and a second communications interface to enable access to the stream of data units by two or more terminals.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: The invention provides a method and system for distributing personalized content to potentially large numbers of recipients. A pool is selected, from among all content available for distribution, of those content elements that will be made available for simultaneous distribution, and personalized content is selected for distribution from that pool. The content of the pool can change with new selections over time. For each individual recipient, content elements in the pool are examined to determine if they are predicted to be of sufficient interest to that recipient for distribution, and if so, those content elements are distributed. If not, successive content elements in the pool are examined, relaxing the standard for sufficient interest, until at least one content element is found and distributed to the individual recipient.

Abstract: A user is enabled to interact with a virtual world environment using an instant messenger application by enabling a user to enter the virtual world environment using the instant messenger application that includes an instant messaging (IM) user interface, generating and managing an avatar to represent the user in the virtual world environment, monitoring a sub-portion of the virtual world environment corresponding to a current location of the user in the virtual world environment, determining descriptions of activities taking place in the sub-portion of the virtual world environment based on the monitoring, and providing the user with the determined descriptions of activities taking place in the sub-portion of the virtual world environment via the IM user interface.

Abstract: A switch having a first communications interface to receive a stream of data units, a buffer to store the payload portion of the data unit, a replicator to duplicate at least the payload portion of the data unit, and a second communications interface to enable access to the stream of data units by two or more terminals.