Abstract: The present invention relates to a method of implanting a prosthesis device in a subject. In one embodiment, this method involves: (i) providing a prosthesis device to be attached to an exposed surface of a bone; (ii) applying bone cement in liquid form to a bone-implant interface region, the bone-implant interface region including a region between the exposed surface of the bone and an outer surface of the prosthesis device; and (iii) contacting the bone cement to the exposed surface of the bone and the outer surface of the prosthesis device under conditions effective to allow the bone cement to cure, thereby resulting in attachment of the prosthesis device to the bone of the subject. The present invention also relates to a kit for implanting a prosthesis device in a subject, a method of performing a joint arthroplasty surgical procedure, and other methods of using bone cement in liquid form.

Abstract: An injector assembly for delivering flowable material to a medical implant, including a tube having a first end and a second end, a connector member and a port connector, where the connector member is coupled to the first end of the tube and the port connector is coupled to the second end of the tube, the connector member being configured to attach to a material delivery mechanism and the port connector being configured to attach to the medical implant. When the material delivery mechanism is actuated, the flowable material passes through the tube to the medical implant. A method of using an injector assembly to deliver a flowable material to a medical implant and bone surface is also described. A kit containing various sized parts for an injector assembly is also described.

Abstract: The invention provides a guide for controlling a surgical instrument, that includes a cutting member configured to resect a portion of anatomy and a sheath. The sheath may have a circular connecting portion with an inner diameter substantially the same as the outer diameter of the surgical instrument to receive the surgical instrument. The sheath may also include at least two distally extending arms connected to the circular connecting portion and a ring connected to the distal portion of the at least two distally extending arms. The sheath may also include a distally extending extension connected to the ring. The guide has a superiorly extending guard connected to the distal portion of the extension and a projection member positioned on a superior surface of the guard. The projection member includes a generally circular base and circular platform that has a diameter larger than the generally circular base.

Abstract: The present invention relates to a femoral prosthesis that includes a cement introduction port which may be used to facilitate delivery or introduction of bone cement into the prosthesis/bone interface after the prosthesis component has been placed on a resurfaced femur bone. The femoral prosthesis may have a keel with undercuts which are configured to assist in controlling the flow of bone cement during implantation and to improve stability of the prosthesis following implantation. The femoral prosthesis is suitable for implantation using arthroscopic, as well as open, surgical procedures. The present prostheses may be used as unicondylar implants in either compartment of the knee or in both compartments of the knee.

Abstract: The invention provides a guide for controlling a surgical instrument, that includes a cutting member configured to resect a portion of anatomy and a sheath. The sheath may have a circular connecting portion with an inner diameter substantially the same as the outer diameter of the surgical instrument to receive the surgical instrument. The sheath may also include at least two distally extending arms connected to the circular connecting portion and a ring connected to the distal portion of the at least two distally extending arms. The sheath may also include a distally extending extension connected to the ring. The guide has a superiorly extending guard connected to the distal portion of the extension and a projection member positioned on a superior surface of the guard. The projection member includes a generally circular base and circular platform that has a diameter larger than the generally circular base.

Abstract: The present invention relates to a method of implanting a prosthesis device in a subject. In one embodiment, this method involves: (i) providing a prosthesis device to be attached to an exposed surface of a bone; (ii) applying bone cement in liquid form to a bone-implant interface region, the bone-implant interface region including a region between the exposed surface of the bone and an outer surface of the prosthesis device; and (iii) contacting the bone cement to the exposed surface of the bone and the outer surface of the prosthesis device under conditions effective to allow the bone cement to cure, thereby resulting in attachment of the prosthesis device to the bone of the subject. The present invention also relates to a kit for implanting a prosthesis device in a subject, a method of performing a joint arthroplasty surgical procedure, and other methods of using bone cement in liquid form.

Abstract: The present invention relates to a tibial prosthesis useful in knee replacement surgeries. The prosthesis includes one or more cement introduction ports which may be used to deliver and control delivery of bone cement to a prosthesis-bone interface after the prosthesis has been positioned on a resurfaced area of a tibia bone. The prosthesis is suitable for implantation using arthroscopic as well as open surgical procedures. The prosthesis may be used as a unicondylar implant in either compartment of the knee or in both compartments of the knee.

Abstract: A resection tether that includes an elongated member having a medial end and a lateral end. The lateral end is configured for attachment to a cutting device and the medial end is configured for attachment to a reference locator positioned in a bone. When attached at both ends, the resection tether controls the movement of the cutting device relative to the reference locator. Further disclosed is an apparatus that includes a tether having an elongated member that includes a medial end and a lateral end. The lateral end is configured for attachment to a bone cutting device and the medial end configured to attach a position on a bone. The apparatus includes a bone cutting device and a reference locator that has been positioned within a bone. Also disclosed are methods for using a tether to perform a bone resection and for creating an inlay bone resection.

Abstract: An implant guide for preparing a bone surface that includes a handle with an attached finger holder and a template head coupled to the handle. The template head is shaped to approximate the outer perimeter of an implant. The implant guide also includes a central opening that has an aperture and hook for receiving a marking device. A relief is positioned adjacent to the aperture to facilitate the engagement between the implant guide and the marking device. The implant guide may include a medial cutting notch and anterior slot for facilitating the preparation of the bone surface. A surgical kit is also disclosed that includes a plurality of implant guides, each having a handle and attached template head. The kit also includes an enclosure that is configured to hold the plurality of implant guides and marking devices. Further disclosed is a surgical method for using the implant guide.

Abstract: An injector assembly for delivering flowable material to a medical implant, including a tube having a first end and a second end, a connector member and a port connector, where the connector member is coupled to the first end of the tube and the port connector is coupled to the second end of the tube, the connector member being configured to attach to a material delivery mechanism and the port connector being configured to attach to the medical implant. When the material delivery mechanism is actuated, the flowable material passes through the tube to the medical implant. A method of using an injector assembly to deliver a flowable material to a medical implant and bone surface is also described. A kit containing various sized parts for an injector assembly is also described.

Abstract: The present invention relates to a tibial prosthesis useful in knee replacement surgeries. The prosthesis includes one or more cement introduction ports which may be used to deliver and control delivery of bone cement to a prosthesis-bone interface after the prosthesis has been positioned on a resurfaced area of a tibia bone. The prosthesis is suitable for implantation using arthroscopic as well as open surgical procedures. The prosthesis may be used as a unicondylar implant in either compartment of the knee or in both compartments of the knee.

Abstract: The present invention relates to a femoral prosthesis that includes a cement introduction port which may be used to facilitate delivery or introduction of bone cement into the prosthesis/bone interface after the prosthesis component has been placed on a resurfaced femur bone. The femoral prosthesis may have a keel with undercuts which are configured to assist in controlling the flow of bone cement during implantation and to improve stability of the prosthesis following implantation. The femoral prosthesis is suitable for implantation using arthroscopic, as well as open, surgical procedures. The present prostheses may be used as unicondylar implants in either compartment of the knee or in both compartments of the knee.

Abstract: The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin™) of Formulas (I), (II), (III), and (IV) wherein R is C1-C10 alkyl or C3 -C10 cycloalkyl and pharmaceutically acceptable salts thereof.

Abstract: A method is provided for making an enantiomerically pure compound of the formula: in which R and R? represent C1-C10 alkyl, C2-C10 alkenyl or C3-C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g.

Abstract: The present invention provides a positioner for controlling the position of a femoral hip implant within the intramedullary canal of a femur.

Abstract: Pro-drug compounds of the formula (I) or (II) and compositions containing them are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. In the above formulae n, P, Q, R1, R2 and R3 are as defined in the specification. The compounds may be used to treat a range of neurological conditions, e.g. epilepsy or pain.

Abstract: The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.