Patents by Inventor DAVID BRUHLMANN

DAVID BRUHLMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for modulating protein mannosylation profiles using maduramycin, narasin, or salinomycin
    Patent number: 11566062
    Abstract: The present invention relates to methods and compositions for modulating mannosylation profile of recombinant proteins expressed by mammalian host cells during the cell culture process, using a polyether ionophore.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: January 31, 2023
    Assignee: ARES TRADING S.A.
    Inventors: David Bruhlmann, Thomas Vuillemin, Martin Jordan, Hervé Broly
  • Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose
    Patent number: 11118208
    Abstract: The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: September 14, 2021
    Assignee: ARES TRADING S.A.
    Inventors: Martin Jordan, Gabrielle Leclercq, Jonathan Souquet, Herve Broly, David Bruhlmann
  • METHODS FOR MODULATING PROTEIN MANNOSYLATION PROFILES USING MADURAMYCIN, NARASIN, OR SALINOMYCIN
    Publication number: 20200339665
    Abstract: The present invention relates to methods and compositions for modulating mannosylation profile of recombinant proteins expressed by mammalian host cells during the cell culture process, using a polyether ionophore.
    Type: Application
    Filed: December 19, 2018
    Publication date: October 29, 2020
    Inventors: DAVID BRUHLMANN, THOMAS VUILLEMIN, MARTIN JORDAN, HERVÉ BROLY
  • Methods for modulating production profiles of recombinant proteins
    Patent number: 10767160
    Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: September 8, 2020
    Assignee: ARES TRADING S.A.
    Inventors: Anais Muhr, David Bruhlmann, Martin Jordan, Herve Broly, Matthieu Stettler
  • Methods for modulating production profiles of recombinant proteins
    Patent number: 10745663
    Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of 4,4?diisothiocyanostilbene-2,2?-disulfonic acid (DIDS) or supplemented with an effective amount of DIDS, whereby production of said protein is increased relative to cells grown without DIDS.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: August 18, 2020
    Assignee: ARES TRADING S.A.
    Inventors: Anais Muhr, David Bruhlmann, Martin Jordan, Herve Broly, Matthieu Stettler
  • METHODS FOR MODULATING PROTEIN GALACTOSYLATION PROFILES OF RECOMBINANT PROTEINS USING PERACETYL GALACTOSE
    Publication number: 20190153497
    Abstract: The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.
    Type: Application
    Filed: May 10, 2017
    Publication date: May 23, 2019
    Inventors: MARTIN JORDAN, GABRIELLE LECLERCQ, JONATHAN SOUQUET, HERVE BROLY, DAVID BRUHLMANN
  • METHODS FOR MODULATING PRODUCTION PROFILES OF RECOMBINANT PROTEINS
    Publication number: 20180320128
    Abstract: The present invention relates to methods and compositions for modulating glycosylation of recombinant proteins expressed by mammalian host cells during the cell culture process. Also disclosed are methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising a disaccharide or a trisaccharide, while keeping the osmolality constant.
    Type: Application
    Filed: November 9, 2016
    Publication date: November 8, 2018
    Inventors: DAVID BRUHLMANN, MARTIN JORDAN
  • METHODS FOR MODULATING PRODUCTION PROFILES OF RECOMBINANT PROTEINS
    Publication number: 20180201896
    Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of 4,4?-diisothiocyanostilbene-2,2?-disulfonic acid (DIDS) or supplemented with an effective amount of DIDS, whereby production of said protein is increased relative to cells grown without DIDS.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 19, 2018
    Inventors: ANAIS MUHR, DAVID BRUHLMANN, MARTIN JORDAN, HERVE BROLY, MATTHIEU STETTLER
  • METHODS FOR MODULATING PRODUCTION PROFILES OF RECOMBINANT PROTEINS
    Publication number: 20180201897
    Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 19, 2018
    Inventors: ANAIS MUHR, DAVID BRUHLMANN, MARTIN JORDAN, HERVE BROLY, MATTHIEU STETTLER