Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: A gas turbine rotor and blade include a root portion, a platform and airfoil portion arranged along a span direction of the rotor blade, the platform located between the root and airfoil portion. The platform has an upstream and downstream side, side faces which extend from upstream to downstream side, an axial groove in each side face extends perpendicular to the span direction with a minor component of extension in span direction. A radial groove in each side face extends towards the axial groove with a component of extension in span direction and a component of extension perpendicular to the span direction. The radial groove has a first end that shows away from the axial groove and a second end that shows towards the axial groove. The second end is located a distance from the axial groove forming a groove free section between the second end and axial groove.

Abstract: A turbomachine rotor blade has a firtree shaped root, to be secured in a rotor disc rotatable around a rotor axis. In a plane perpendicular to the rotor axis, the root has a first, second, and third root lobe with a first, second, and third root contact face. Each of the first, second, and third root contact face is angled relative to a radial root bottom axis with a first, second, and third root angle, respectively. The first root angle is smaller than the second and the second root angle is substantially equal to the third. A turbomachine rotor disc has a firtree shaped slot having a first, second, and third slot angle, the first slot angle being smaller than the second and the second slot angle being substantially equal to the third. A gas turbine engine has the turbomachine rotor herein.

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

Abstract: A drive assembly for a drug delivery device comprises a rotation member being configured to be rotated in a first direction during setting of a dose of a drug and to be rotated in a second direction during delivery of the dose, a drive component being configured to follow rotational movement of the rotation member in the second direction during delivery of the dose and a stop member being configured to prevent rotational movement of the drive component in the first direction. The drive component comprises a first drive part and a second drive part, coupled to each other such that relative rotational movement of the first and second drive parts is prevented and relative axial movement is permitted.

Abstract: A guide vane arrangement of a gas turbine and a method of manufacturing a guide vane arrangement of a gas turbine are provided herein. The guide vane arrangement includes a first guide vane device including a first radially inner platform and a first number of first airfoils, and a second guide vane device including a second radially inner platform and a second number of second airfoils. The first guide vane device and the second guide vane device are arranged along a circumferential direction of the turbine, wherein the first number of the first airfoils differs to the second number of the second airfoils. The first guide vane device is designed with a higher heat resistance than the second guide vane device.

Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.

Abstract: A utility sled is formed from a lightweight material and includes a handle flexibly attached to the front end thereof. The handle includes a hook that is seated within a small opening of the utility sled when not in use. A pair of retractable wheels is attached to an exterior of each sidewall of the utility sled. The sidewalls are biased outward when no load is present. When loaded, the sidewalls advantageously tend to straighten vertically. The formed bottom of the sled includes a plurality of ribs which both add strength to the sled as well as function as sled runners when the wheels are retracted. The ribs operate to reduce friction between the sled bottom and the underlying surface.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: The drive mechanism for a drug delivery device comprises a piston rod, which is displaced in a distal direction for a delivery of a dose and in a proximal direction for a reset, and a resilient member, which acts on the piston rod during a reset and tends to restrict the movement of the piston rod in the proximal direction. The resilient member may be a biasing member provided for an automatic reset, a compression spring entering the piston rod or a torsion spring provided to generate a rotation. The drug delivery device is provided with such a drive mechanism.

Abstract: A drive assembly (70) for a drug delivery device (1) comprises a rotation member (21) being configured to be rotated in a first direction (44) during setting of a dose of a drug and to be rotated in a second direction (47) during delivery of the dose, a drive component (20) being configured to follow rotational movement of the rotation member (21) in the second direction (47) during delivery of the dose and a stop member (26) being configured to prevent rotational movement of the drive component (20) in the first direction (44). The drive component (20) comprises a first drive part (71) and a second drive part (72), coupled to each other such that relative rotational movement of the first and second drive parts (71, 72) is prevented and relative axial movement is permitted.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: The present invention is based, in part, upon the discovery of charged lipids that provide advantages when used in lipid particles for the in vivo delivery of a therapeutic agent. As such, described herein are compounds useful for delivering a nucleic acid to a cell.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: The drive mechanism for a drug delivery device comprises a piston rod, which is displaced in a distal direction for a delivery of a dose and in a proximal direction for a reset, and a rotatable drive member, which is threadedly engaged with the piston rod and rotates during the delivery of the dose. A biasing member is provided, which is loaded by the rotation of the drive member during the delivery of the dose and tends to rotate the piston rod with respect to the drive member in such a way that the piston rod is screwed into the drive member and is thereby advanced in the proximal direction. The drug delivery device is provided with such a drive mechanism.

Abstract: A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing.