Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: A web transporting device usable in a rotary printing press or folder, includes a rotatably driven transport roller having a fixed axis and at least one engagable nip roller having an axis substantially parallel to the fixed axis and being engagable with the driven transport roller. The engagable nip roller has a length corresponding to a maximum width of the web processable in the printing press. A removable nip sleeve is provided which is axially mounted on the engagable nip roller. The removable nip sleeve has an least one ring-shaped annular gap disposed axially along its length which allows the web to ripple as it passes through the web transporting device without causing permanent wrinkles or creases to form in the web. A counterbalancing mechanism is also provided which stabilizes the engagable nip roller in a maintenance position as the removable nip sleeve is replaced.

Abstract: A method of lubricating a bearing (58) in a printing unit (14) includes the step of directing a quantity of grease into the bearing (58), and the step of directing pressurized air into contact with the grease. The bearing (58) supports a printing cylinder (16) for rotation in the printing unit (14), and includes a plurality of rolling elements (100) between a pair of opposed bearing race surfaces (94, 88). A predetermined quantity (160) of grease is directed to flow from a hydraulic pump (114) to the space between the bearing race surfaces (94, 88). The pressurized air is directed to flow from a pneumatic pump (132) into contact with the grease to remove a first portion of the predetermined quantity (160) of grease from the space between the bearing race surfaces (94, 88). The pressurized air further spreads a second portion of the predetermined quantity (160) of grease into coatings (190) which extend over the rolling element surfaces (104) and the bearing race surfaces (94, 88).

Abstract: A web transporting device usable in a rotary printing press or folder, includes a rotatably driven transport roller having a fixed axis and at least one engagable nip roller having an axis substantially parallel to the fixed axis and being engagable with the driven transport roller. The engagable nip roller has a length corresponding to a maximum width of the web processable in the printing press. A removable nip sleeve is provided which is axially mounted on the engagable nip roller. The removable nip sleeve has at least one ring-shaped annular gap disposed axially along its length which allows the web to ripple as it passes through the web transporting device without causing permanent wrinkles or creases to form in the web. A counterbalancing mechanism is also provided which stabilizes the engagable nip roller in a maintenance position as the removable nip sleeve is replaced.