Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A system may include an electronic device that includes an enclosure having a transparent cover. The electronic device may also include a display positioned below the transparent cover and configured to display a first graphical user interface and a second graphical user interface different from the first graphical user interface, and a touch sensor positioned below the transparent cover and configured to detect touch inputs applied to the transparent cover. The system may also include a protective case that includes a shell defining a cavity and configured to at least partially cover the enclosure of the electronic device when the electronic device is positioned in the cavity, and a near-field wireless communication antenna coupled to the shell and detectable by the electronic device. In response to detecting the near-field wireless communication antenna, the electronic device may be configured to switch from the first graphical user interface to the second graphical user interface.

Abstract: A system may include an electronic device that includes an enclosure having a transparent cover. The electronic device may also include a display positioned below the transparent cover and configured to display a first graphical user interface and a second graphical user interface different from the first graphical user interface, and a touch sensor positioned below the transparent cover and configured to detect touch inputs applied to the transparent cover. The system may also include a protective case that includes a shell defining a cavity and configured to at least partially cover the enclosure of the electronic device when the electronic device is positioned in the cavity, and a near-field wireless communication antenna coupled to the shell and detectable by the electronic device. In response to detecting the near-field wireless communication antenna, the electronic device may be configured to switch from the first graphical user interface to the second graphical user interface.

Abstract: A system may include an electronic device that includes an enclosure having a transparent cover. The electronic device may also include a display positioned below the transparent cover and configured to display a first graphical user interface and a second graphical user interface different from the first graphical user interface, and a touch sensor positioned below the transparent cover and configured to detect touch inputs applied to the transparent cover. The system may also include a protective case that includes a shell defining a cavity and configured to at least partially cover the enclosure of the electronic device when the electronic device is positioned in the cavity, and a near-field wireless communication antenna coupled to the shell and detectable by the electronic device. In response to detecting the near-field wireless communication antenna, the electronic device may be configured to switch from the first graphical user interface to the second graphical user interface.

Abstract: A system may include an electronic device that includes an enclosure having a transparent cover. The electronic device may also include a display positioned below the transparent cover and configured to display a first graphical user interface and a second graphical user interface different from the first graphical user interface, and a touch sensor positioned below the transparent cover and configured to detect touch inputs applied to the transparent cover. The system may also include a protective case that includes a shell defining a cavity and configured to at least partially cover the enclosure of the electronic device when the electronic device is positioned in the cavity, and a near-field wireless communication antenna coupled to the shell and detectable by the electronic device. In response to detecting the near-field wireless communication antenna, the electronic device may be configured to switch from the first graphical user interface to the second graphical user interface.

Abstract: A method and a composition of matter formed in accordance with the method for anchoring and/or impregnation of a biological vehicle with a cargo molecule includes mixing the biological vehicle and the cargo molecule in suspension to create a cargo molecule and biological vehicle mixture, placing the cargo molecule and biological vehicle mixture inside a pressure vessel, subjecting the cargo molecule and biological vehicle mixture to subcritical or supercritical fluid, returning pressure and temperature within the pressure vessel to ambient conditions, and recovering a biological vehicle bound cargo molecule.

Abstract: A process for creating acellular donor soft tissue by removing contaminants such as cells by extraction using a fluid at supercritical temperature and pressures while preserving the integrity of the soft tissue. The soft tissue is maintained in contact with the fluid in a pressure vessel at supercritical temperature and pressures for a period of time and then the pressure vessel is rapidly depressurized.

Abstract: A process for creating acellular donor soft tissue by removing contaminants such as cells by extraction using a fluid at supercritical temperature and pressures while preserving the integrity of the soft tissue. The soft tissue is maintained in contact with the fluid in a pressure vessel at supercritical temperature and pressures for a period of time and then the pressure vessel is rapidly depressurized.

Abstract: A process for cleaning donor soft tissue by removing contaminants by extraction using a fluid at supercritical temperature and pressures while preserving the integrity of the tissue.

Abstract: A sterilization method for drugs to achieve a 6-log reduction in CFUs of industry standard bacteria and bacterial spores is effective by subjecting the drugs to a chemical additive-containing carbon dioxide sterilant fluid at or near its supercritical pressure and temperature conditions and controlling the pressurization and depressurization rates.

Abstract: A sterilization method for drugs to achieve a 6-log reduction in CFUs of industry standard bacteria and bacterial spores is effective by subjecting the drugs to a chemical additive-containing carbon dioxide sterilant fluid at or near its supercritical pressure and temperature conditions and controlling the pressurization and depressurization rates.

Abstract: A process for cleaning donor soft tissue by removing contaminants by extraction using a fluid at supercritical temperature and pressures while preserving the integrity of the tissue.

Abstract: A method and apparatus for streaming of data from a remote computer to a recordable media production system is described that utilizes a client computer based application that reduces or eliminates the need for caching of data at the production system, as well as increases security and reliability. This is accomplished in the various embodiments with a client computer application that is run at the user level reducing system complexity and the need for system administrator involvement and oversight. The application pushes data to a production system “on the fly” without requiring a cache or extra disk space.

Abstract: A media recording system is described which insures a fast uninterrupted recording. The system includes a media recorder and a data storage unit assigned to the media recorder. A controller is provided which operates parallel to a central processing unit such that data is transferred from the data storage unit to the media recorder without interruption. The media can be a recordable compact disc (CD-R) and the controller can be a programmable SCSI bus.

Abstract: An apparatus for cleaning depositions of particulate matter from the inside of tubular piping while the piping is in use. The apparatus is remote controlled in order to operate in hazardous environments. A housing containing brush and shaft assemblies is mounted on top of the tubular piping. Pneumatic cylinders provide linear motion. A roller nut bearing provides rotary motion. The combined motion causes the brush assembly to rotate as it travels along the tube dislodging particulate matter.

Abstract: The Venetian blind which has a headrail, a series of slats and an extruded bottom rail includes a longitudinal resilient bumper positioned in a bottom longitudinal slat of the bottom rail and extending from the bottom of the rail. Resilient end caps having the same transverse contour as the bumper close the rail ends and together with the bumper, seal the bottom rail from light transmission between it and a window sill and a window vertical edge. An extruded aluminum or plastic headrail with resilient end pieces has spaced tangs extending from a tilt and left mechanism-supporting horizontal bottom wall forming an inverted U-shaped open compartment. This compartment receives the top portion of the uppermost blind slat in a slats tilted closed position to block out light transmission and sight lines under the headrail. A resilient flipper seal obstructs light at the top of the headrail. The bottom rail may also include a storage volume for replacement slats.

Abstract: A window blind headrail mounting a Venetian blind or pleated blind includes a headrail enclosure, preferably of extruded aluminum construction, having integrally spaced headrail hooks and a hook keeper extending from the enclosure edges. A pair of or more universal mounting brackets are alternatively attachable to either a horizontal surface at the top of a window opening or to a vertical wall or vertical top surface of a window frame, dependent upon the type of installation. The brackets thus can be mounted horizontally or vertically on these respective surfaces. The mounting bracket includes a hook extending from each end of a base portion fixed to a window-adjacent surface. One of the hooks of each bracket contains a discrete wave-like leaf spring.