Patents by Inventor David C. Griffith

David C. Griffith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 10561675
    Abstract: Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 18, 2020
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: David C. Griffith, Michael N. Dudley, Olga Rodny
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20200000817
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: January 31, 2019
    Publication date: January 2, 2020
    Inventors: Jeffery S. LOUTIT, Elizabeth E. MORGAN, Michael N. DUDLEY, David C. GRIFFITH, Olga LOMOVSKAYA
  • TETRACYCLINE COMPOSITIONS
    Publication number: 20200000828
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Application
    Filed: February 27, 2019
    Publication date: January 2, 2020
    Inventors: David C. GRIFFITH, Serge BOYER, Scott HECKER, Michael N. DUDLEY
  • AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF
    Publication number: 20190381057
    Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
    Type: Application
    Filed: January 17, 2019
    Publication date: December 19, 2019
    Inventors: Mark W. SURBER, Keith A. BOSTIAN, Michael N. DUDLEY, Olga RODNY, David C. GRIFFITH
  • METHODS OF TREATING BACTERIAL INFECTIONS
    Publication number: 20190336475
    Abstract: Methods of treating or ameliorating urinary tract infection (UTI), including complicated urinary tract infection (cUTI) and acute pyelonephritis (AP), comprising administering a composition comprising a cyclic boronic acid ester vaborbactam in combination with meropenem are disclosed herewith.
    Type: Application
    Filed: January 8, 2018
    Publication date: November 7, 2019
    Inventors: Jeffrey S. LOUTIT, Michael N. DUDLEY, Elizabeth E. MORGAN, Karen FUSARO, David C. GRIFFITH, Olga LOMOVSKAYA
  • AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS
    Publication number: 20190321371
    Abstract: The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
    Type: Application
    Filed: November 19, 2018
    Publication date: October 24, 2019
    Inventors: David C. GRIFFITH, Michael N. DUDLEY, Mark W. SURBER, Keith A. BOSTIAN, Olga RODNY
  • METHODS OF TREATING BACTERIAL INFECTIONS
    Publication number: 20190105337
    Abstract: Methods of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester Compound I in combination with meropenem are disclosed herewith. In some embodiments, the bacterial infection is a lower respiratory tract infection.
    Type: Application
    Filed: July 6, 2018
    Publication date: April 11, 2019
    Inventors: David C. Griffith, Michael N. Dudley, Jeffrey S. Loutit, Olga Lomovskaya
  • Use of aerosolized levofloxacin for treating cystic fibrosis
    Patent number: 10231975
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 19, 2019
    Assignee: Horizon Orphan LLC
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20190076449
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: November 13, 2018
    Publication date: March 14, 2019
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 10183034
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 22, 2019
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Pharmaceutical compositions comprising cyclic boronic acid ester derivatives
    Patent number: 10172874
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 8, 2019
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Aerosol fluoroquinolone formulations for improved pharmacokinetics
    Patent number: 10149854
    Abstract: The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: December 11, 2018
    Assignee: Horizon Orphan LLC
    Inventors: David C. Griffith, Michael N. Dudley, Mark W. Surber, Keith A. Bostian, Olga Rodny
  • THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20180214465
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 2, 2018
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
    Publication number: 20180207183
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: March 26, 2018
    Publication date: July 26, 2018
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Cyclic boronic acid ester derivatives and methods of making the same
    Patent number: 10004758
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: June 26, 2018
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS
    Publication number: 20180104252
    Abstract: The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
    Type: Application
    Filed: June 28, 2017
    Publication date: April 19, 2018
    Inventors: David C. Griffith, Michael N. Dudley, Mark W. Surber, Keith A. Bostian, Olga Rodny
  • TOPICAL USE OF LEVOFLOXACIN FOR REDUCING LUNG INFLAMMATION
    Publication number: 20180085462
    Abstract: The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided.
    Type: Application
    Filed: October 11, 2017
    Publication date: March 29, 2018
    Inventors: Michael N. Dudley, Ruslan Y. Tsivkovski, David C. Griffith, Olga Rodny
  • USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS
    Publication number: 20180085376
    Abstract: Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
    Type: Application
    Filed: June 14, 2017
    Publication date: March 29, 2018
    Inventors: Jeffery S. Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Olga Lomovskaya
  • TETRACYCLINE COMPOSITIONS
    Publication number: 20180078570
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Application
    Filed: July 26, 2017
    Publication date: March 22, 2018
    Inventors: David C. Griffith, Serge Boyer, Scott Hecker, Michael N. Dudley
  • CYCLIC BORONIC ACID ESTER DERIVATIVES AND METHODS OF MAKING THE SAME
    Publication number: 20180071325
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: June 15, 2017
    Publication date: March 15, 2018
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer