Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating primary liver cancers such as hepatocellular carcinoma (HCC) and intra-hepatic cholangiocarcinoma (ICC) comprising administering TLR9 agonists to the liver.

Abstract: In general, techniques are described for organizing execution of distributed operating systems for network devices. A device comprising hardware computing nodes may be configured to perform the techniques. The hardware computing nodes may execute a protocol by which to discover a topology of the plurality of hardware computing nodes, and determine, based on the topology, a subset of the plurality of hardware computing nodes to manage execution of a distributed operating system. The determined subset of the plurality of hardware computing nodes may execute a communication bus by which to synchronize operating system state information between the subset of the plurality of hardware computing nodes. The hardware computing nodes may further execute, based on the operating system state information, the distributed operating system to provide an execution environment in which one or more applications execute.

Abstract: A method and system for detecting and preventing Stress Corrosion Cracking (SCC) in buried pipelines or other structures is presented. The basic principle of the invention is to use a plurality of test coupons which are placed in the same environment as a pipeline or other structure of interest as indicators of the development of SCC in the structure of interest. Loading and temperature of the test coupons are controlled. The test coupons are given a range of different Cathodic Protection (CP) levels, with the range of CP levels selected so as to encompass the CP level at which SCC would be expected to occur. The occurrence of cracking in a test coupon indicates levels of CP which will sustain SCC. SCC is prevented in the structure by application of a level of CP which did not sustain SCC.