Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: Co-manipulation robotic systems are described herein that may be used for assisting with laparoscopic surgical procedures. The co-manipulation robotic systems allow a surgeon to use commercially-available surgical tools while providing benefits associated with surgical robotics. Advantageously, the surgical tools may be seamlessly coupled to the robot arms using a disposable coupler while the reusable portions of the robot arm remain in a sterile drape. Further, the co-manipulation robotic system may operate in multiple modes to enhance usability and safety, while allowing the surgeon to position the instrument directly with the instrument handle and further maintain the desired position of the instrument using the robot arm.

Abstract: A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

Abstract: A portable medical imaging system and method, of which the system includes a movable station having a movable C-arm, an imaging signal transmitter attached to the movable C-arm, and an imaging sensor positioned generally opposite to the imaging signal transmitter and attached to the movable c-arm. The imaging sensor is configured to rotate relative to a point approximately on a center axis of the movable C-arm independently of the imaging signal transmitter, so as to change an angle of incidence for a signal transmitted from the imaging signal transmitter to the imaging sensor, and provide a field-of-view that is larger than the field-of-view of the imaging sensor at a single position.

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: The subject matter described herein provides systems and techniques to address the challenges of growing hardware and workload heterogeneity using a Warehouse-Scale Computer (WSC) design that improves the efficiency and utilization of WSCs. The WSC design may include an abstraction layer and an efficiency layer in the software stack of the WSC. The abstraction layer and the efficiency layer may be designed to improve job scheduling, simplify resource management, and drive hardware-software co-optimization using machine learning techniques and automation in order to customize the WSC for applications at scale. The abstraction layer may embrace platform/hardware and workload diversity through greater coordination between hardware and higher layers of the WSC software stack in the WSC design. The efficiency layer may employ machine learning techniques at scale to realize hardware/software co-optimizations as a part of the autonomous WSC design.

Abstract: Among other things, the present disclosure provides designed APOC3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: Various aspects include a wearable audio device having active noise reduction (ANR). In some cases, a method for processing audio signals includes receiving a noise reduction signal configured to modify an audio signal and generate a noise reduced audio signal, the noise reduction signal having a nominal loop gain; and generating an adjusted noise reduction signal in response to a detected adverse low frequency event, the adjusted noise reduction signal having a modulated loop gain configured to reduce artifacts in the noise reduced audio signal.

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

Abstract: The invention provides an associative polymer, a powder, and a process for making a powder including, networking one or more associative polymers and one or more optional surfactants to form a wet gel, and forming a powder from the wet gel, wherein the associative polymer(s) have a weight average molecular weight of from about 10 kDa to about 2,000 kDa.

Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: An anti-fouling composition, and uses thereof in the industrial preparation of ethylenically unsaturated monomers comprising at least one heteroatom, such as acrylic monomers are disclosed.

Abstract: A composite foam article is disclosed herein. The composite foam article comprises a polyurethane foam core presenting a first surface and a second surface facing opposite the first surface. A first skin is disposed on the first surface and a second skin is disposed on the second surface. The polyurethane foam core has a density of 15-80 kg/m3. The first and second skins comprise a plurality of fibers and a polymeric binder. The composite foam article has a weight per unit area of 500-1000 g/m2 and a strength of greater than 17 N at a post-compression thickness of greater than 2 mm when tested in according with SAE J949 at 23° C.

Abstract: Compositions and colloidal particles are provided that may be used to improve a papermaking process. The compositions and colloidal particles may include a polymer and an inorganic salt. A papermaking process carried out using the presently disclosed compositions and colloidal particles may produce a paper product that has increased strength properties.

Abstract: Methods and apparatus for modulating light using a tunable light modulation device. The tunable light modulation devices comprises an elastomer structure including at least one elastomer layer, a compliant electrode network of conducting fibers arranged on a first surface of the at least one elastomer layer, a patterned electric conductor arranged on a second surface of the at least one elastomer layer opposite the first surface. The patterned electric conductor includes a plurality of individually-addressable sections, and the compliant electrode network is configured to compress the at least one elastomer layer in the presence of an electric field between the compliant electrode network and one or more of the individually-addressable sections of the patterned electric conductor to produce a voltage-dependent roughening of the at least one elastomer layer.

Abstract: Disclosed herein are implantable devices coated with a reagent, and methods of preparing and utilizing such devices. The implantable device may comprise an implantable light conduit. The present disclosure enables a more precise registration between the reagent and the device implanted in the target tissue of a subject.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact, a first oscillating rod communicatively and operatively connected to a first movable contact, a second oscillating rod communicatively and operatively connected to a second movable contact, a link rod communicatively and operable connected to the first and second oscillating rods, and a guide plate. The automatic transfer switch is operable to position the guide plate based at least on a state of a solenoid. A permanent magnetic actuator communicatively and operatively connected to the link rod via a third oscillating rod is operable to rotate the first oscillating rod or the second oscillating rod based at least on the position of the guide plate.

Abstract: Crucible for growing single crystals, formed from W, Mo, Re, an alloy or a base alloy of these metals, and a process for producing a crucible (2), wherein at least part of an outwardly facing outer face (4) of the crucible (2) has, at least in certain regions, a profile with a mean profile depth (a) of between 5 and 500 ?m.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact, a first oscillating rod communicatively and operatively connected to a first movable contact, a second oscillating rod communicatively and operatively connected to a second movable contact, a link rod communicatively and operable connected to the first and second oscillating rods, and a guide plate. The automatic transfer switch is operable to position the guide plate based at least on a state of a solenoid. A permanent magnetic actuator communicatively and operatively connected to the link rod via a third oscillating rod is operable to rotate the first oscillating rod or the second oscillating rod based at least on the position of the guide plate.

Abstract: A facility procuring information about a distinguished property from its owner that is usable to refine an automatic valuation of the distinguished property is described. The facility displays information about the distinguished property used in the automatic valuation of the distinguished property. The facility obtains user input from the owner adjusting at least one aspect of information about the distinguished property used in the automatic valuation of the distinguished property. The facility then displays to the owner a refined valuation of the distinguished property that is based on the adjustment of the obtained user input.