Patents by Inventor David Conegliano
David Conegliano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220334139Abstract: The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.Type: ApplicationFiled: June 7, 2022Publication date: October 20, 2022Inventors: Josiah Sliz, Daniel Levner, Brian Zuckerman, Norman Wen, Jonathan Rubins, Tanvi Shroff, Christopher David Hinojosa, Grace Ahn, Victor Antontsev, Jefferson Puerta, David Conegliano, S. Jordan Kerns
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Publication number: 20220155328Abstract: The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.Type: ApplicationFiled: November 30, 2021Publication date: May 19, 2022Inventors: JOSIAH SLIZ, Daniel Levner, Brian Zuckerman, Norman Wen, Jonathan Rubins, Tanvi Shroff, Christopher David Hinojosa, Grace Ahn, Victor Antontsev, Jefferson Puerta, David Conegliano, S. Jordan Kerns
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Patent number: 11150255Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: GrantFiled: July 12, 2017Date of Patent: October 19, 2021Assignee: EMULATE, Inc.Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoungshin Park, Antonio Varone, Andries Van der Meer, Monicah Otieno, David Conegliano
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Patent number: 10989721Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: GrantFiled: July 12, 2017Date of Patent: April 27, 2021Assignee: EMULATE, Inc.Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoungshin Park, Antonio Varone, Andries Van der Meer, Monicah Otieno, David Conegliano
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Publication number: 20210115406Abstract: The present invention relates to a combination of microbes, cell culture systems and microfluidic fluidic systems for use in providing a human Intestine On-Chip with optimal intestinal motility. More specifically, in some embodiments, a microfluidic chip containing intestinal epithelial cells co-cultured with intestinal endothelial cells in the presence of bacteria, such as probiotic bacteria, may find use in providing an Intestine-On-Chip for testing intestinal motility function. In some embodiments, an Intestine On-Chip may be used for identifying (testing) therapeutic compounds continuing probiotic microbes or compounds for inducing intestinal motility for use in treating gastrointestinal disorders or diseases related to intestinal function.Type: ApplicationFiled: November 4, 2020Publication date: April 22, 2021Inventors: S. Jordan Kerns, Catherine Karalis, Janna Nawroth, Remi Villenave, Jenifer Obrigewitch, Doris Roth, Michael Salmon, Athanasia Apostolou, David Conegliano
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Publication number: 20210062129Abstract: An in vitro microfluidic “organ-on-chip” device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.Type: ApplicationFiled: August 3, 2020Publication date: March 4, 2021Inventors: Janna Nawroth, Riccardo Barrile, David Conegliano, Remi Villenave, Carolina Carolina, Justin Nguyen, Antonio Varone, Catherine Karalis, Geraldine Hamilton
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Patent number: 10908171Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: GrantFiled: July 12, 2017Date of Patent: February 2, 2021Assignee: EMULATE, INC.Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoungshin Park, Antonio Varone, Andries Van der Meer, Monicah Otieno, David Conegliano
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Patent number: 10852311Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: GrantFiled: July 12, 2017Date of Patent: December 1, 2020Assignee: Emulate, Inc.Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoungshin Park, Antonio Varone, Andries Van der Meer, Monicah Otieno, David Conegliano
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Patent number: 10228381Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: GrantFiled: July 12, 2017Date of Patent: March 12, 2019Assignee: EMULATE, Inc.Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoungshin Park, Antonio Varone, Andries Van der Meer, Monicah Otieno, David Conegliano
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Patent number: 10202569Abstract: A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.Type: GrantFiled: July 22, 2016Date of Patent: February 12, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Richard Novak, David Conegliano, Liliana Teixeira, Donald E. Ingber
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Publication number: 20180017582Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017586Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Va der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017584Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Noeman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017583Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180017585Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180015455Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20180015462Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Daniel Levner, Christopher David Hinojosa, Norman Wen, Jacob Fraser, Justin Nguyen, Riccardo Barrile, Geraldine Hamilton, Catherine Karalis, Hyoung Shin Park, Antonio Varone, Andries Van der Meer, Monica Otieno, David Conegliano
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Publication number: 20170022464Abstract: A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Inventors: Richard Novak, David Conegliano, Liliana Teixeira, Donald E. Ingber