Abstract: New methods for treating patents for urothelial cancer (UC) include combining selected phenotypic variables with levels of genotypic expression into a metric, the “G+P INDEX.” The G+P INDEX combines age, sex, smoking history, presence of hematuria, and frequency of hematuria with genotypic expression of the genetic markers, MDK, CDC2, HOXA13, IGFBP5, and optionally IL8Rb, then determining of the G+P INDEX value obtained for a patient is within one of three groups, either: (1) at High Risk of UC, (2) at Risk of UC, or (3) at Low Risk of UC. For groups 1 and 2, further clinical and laboratory work up or treatment is indicated, and patients in group 3 are monitored periodically to determine the need for further clinical workup. Using the G+P INDEX can save substantial time, effort, and funds by avoiding unnecessary medical diagnostic procedures for patients having or are at risk for developing UC.

Abstract: New methods for identifying patents with hematuria who are at low risk of having urothelial cancer (UC) include combining selected phenotypic variables with levels of genotypic expression into a new metric, the “G+P INDEX.” The G+P INDEX combines age, sex, smoking history, presence of hematuria, and frequency of hematuria with genotypic expression of the genetic markers, MDK, CDC2, HOXA13, IGFBP5, and optionally IL8Rb, then determining of the G+P INDEX value obtained for a patient is within one of three groups, either: (1) at High Risk of UC, (2) at Risk of UC, or (3) at Low Risk of UC. For groups 1 and 2, further clinical and laboratory work up is indicated, and patients in group 3 are monitored periodically to determine the need for further clinical workup. Using the G+P INDEX can save substantial time, effort, and funds by avoiding unnecessary medical diagnostic procedures for patients at Low Risk of UC.

Abstract: New methods for identifying patents with hematuria who are at low risk of having urothelial cancer (UC) include combining selected phenotypic variables with levels of genotypic expression into a new metric, the “G+P INDEX.” The G+P INDEX combines age, sex, smoking history, presence of hematuria, and frequency of hematuria with genotypic expression of the genetic markers, MDK, CDC2, HOXA13, IGFBP5, and optionally IL8Rb, then determining of the G+P INDEX value obtained for a patient is within one of three groups, either: (1) at High Risk of UC, (2) at Risk of UC, or (3) at Low Risk of UC. For groups 1 and 2, further clinical and laboratory work up is indicated, and patients in group 3 are monitored periodically to determine the need for further clinical workup. Using the G+P INDEX can save substantial time, effort, and funds by avoiding unnecessary medical diagnostic procedures for patients at Low Risk of UC.

Abstract: The cheat verification system includes a remote cheatline which a player can contact by telephone. The cheatline has a processor 5 containing ID codes identifying player-selectable cheats. A player obtains a bonus code from the games console and supplies the bonus code to the cheatline operator. The player selects a cheat from a number of available options and the processor 5 combines the corresponding ID code with the bonus code according to an encryption process to generate a verification code which is supplied to the player. The player inputs the verification code to the console where it is decrypted enabling the bonus code and the ID code to be recovered under the control of verification software in the video game. Provided the bonus code derived from the verification code matches the bonus code obtained by the player from the games console the selected cheat will be implemented.

Abstract: The invention provides methods for increasing viral titre in a sample. The methods utilize specific binding members such as lectins and antibodies to bind the virus particles such that they can be concentrated. The invention further provides methods for isolating viral particles from a sample, e.g. blood. There is also provided materials and methods for targeting viral particles to particular tissues using antibodies or paramagnetic particles.

Abstract: An interfacing device for connecting the processing unit of a computer games system to an external data storage medium has a user-operable selection unit for generating a user-selected address and user-selected data. The user-operable selection unit may comprise user-operable switches or electronic latches that are set by a program in response to selections made by the user by means of a joystick, keypad or any other input device. An address comparison unit compares the user-selected address with the addresses from the processing unit, and a data switching device causes the user-selected data to be substituted for data in the storage medium whenever the compared addresses are the same. Instead of a user-operable selection unit, preselected addresses and preselected data may be stored in a ROM, which in one embodiment changes the way the computer interprets external memory and in another changes the computer's internal memory itself.

Abstract: An interfacing device for connecting the processing unit of a computer games system to an external data storage medium has a user-operable selection unit for generating a user-selected address and user-selected data. The user-operable selection unit may comprise user-operable switches or electronic latches that are set by a program in response to selections made by the user by means of a joystick, keypad or any other input device. An address comparison unit compares the user-selected address with the addresses from the processing unit, and a data switching device causes the user-selected data to be substituted for data in the storage medium whenever the compared addresses are the same. Instead of a user-operable selection unit, preselected addresses and preselected data may be stored in a ROM, which in one embodiment changes the way the computer interprets external memory and in another changes the computer's internal memory itself.