Abstract: The present invention relates to peptides having psychopharmacological properties, of the formula: ##STR1## wherein A represents the aminoacid residue Arg, Lys or Leu andR represents ##STR2## as well as the functional derivatives thereof.

Abstract: The invention relates to the use of (2-9)-.alpha.-endorfine for dopaminergic and vasopressin-releasing properties.

Abstract: The present invention relates to peptides with psychopharmacological properties of the formula ##STR1## wherein R represents ##STR2## A represents the amino acid residue Arg, Lys or Leu and Y represents the group OH or the group Gly-OH, as well as functional derivatives thereof.

Abstract: The present invention is dealing with a pharmaceutical composition containing a peptide of the formula:R.sub.1 -L-Tyr-L-Val-L-Met-Gly-L-His-L-Phe-L-Arg-L-Trp-L-Asp-L-Arg-L-Phe-R.sub.2 Iin whichR.sub.1 represents hydrogen or a lower aliphatic acyl (1-6 C) group andR.sub.2 represents the group --OH or --Gly--OH,as well as salts, esters and amides thereof.

Abstract: The present invention relates to novel psycho-pharmacological active peptides and peptide derivatives of the formula:A-R-L-Ser-R.sub.1 -L-Thr-L-Pro-L-Leu-L-Val-L-Thr-BwhereinR represents the amino acid residue L-Lys or L-Arg,R.sub.1 represents the amino acid residue L-Glu or L-Gln,B represents one of the following amino acid or peptide-radicals:L-Leu-OH, (.alpha.-dehydro)Leu-OHD-Leu-OHL-Leu-L-Phe-OHL-Leu-L-Phe-L-Lys-OHL-MeLeu-OHor the radical ##STR1## and A represents one of the following radicals or residues: hydrogenH-L-GluZ.sub.1 -L-GluZ.sub.2 -L-Ser-L-Glu-H-Q.sub.1 -L-Thr-L-Ser-L-Glu-Q.sub.2 -L-Thr-L-Ser-L-Glu-Z.sub.3 -Q.sub.1 -L-Thr-L-Ser-L-Glu- orH.sub.2 N-ALK-CO-L-Phe-Q.sub.1 -L-Thr-L-Ser-L-Glu-in whichZ.sub.1 represents H-L-Ser, H-D-Ser, desamino-Ser, 2,3-dihydroxy propanoyl or H.sub.2 N-ALK-CO-,Z.sub.2 represents H-L-Thr, H-D-Thr, desamino-Thr, 2,3-dihydroxybutanoyl or H.sub.2 N-ALK-CO;Q.sub.1 represents L-Met, L-Met(O), L-Met (O.sub.2) or L-LeuQ.sub.

Abstract: Novel and biologically useful peptides of the formula: A.sub.1 -A.sub.2 -L-Phe-X-L-Thr-L-Ser-R.sub.1 -Y-L-Ser-R.sub.2 -L-Thr-L-Pro-L-Leu-L-Val-L-Thr-B are disclosed (together with pharmaceutical compositions comprising a pharmaceutically effective amount of same) wherein:(a) A.sub.1 and A.sub.2 each represent an aminoacid residue of the formula H.sub.2 N-ALK-CO-, where ALK is an alkylidene group with 1 to 6 carbon atoms inclusively;(b) X is an amino-acid residue selected from the group consisting of L-Met, L-Met(O), L-Met(O.sub.2) and L-Leu;(c) R.sub.1 and R.sub.

Abstract: Biologically active novel peptide compounds are disclosed of the formulaA-L-B-D-Lys-L-Phe-Gly-(L or D)Lys-L-Pro-L-Val-Gly-L-Lys-L-Lys-Xor a pharmaceutically acceptable non-toxic functional derivative thereof; A is a N-terminal chain prolongation selected from the group consisting of (1) hydrogen and (2) N-acyl radicals derived from (a) alkyl carboxylic acids having from one to about six carbons, (b) aralkyl carboxylic acids having from seven to about ten carbons, (c) amino acids, (d) peptides, (e) the N-alkylcarbonyl or N-aralkylcarbonyl derivatives of the amino acids, and (f) the N-alkylcarbonyl or N-aralkylcarbonyl derivatives of the peptides; B is an amino-acid residue selected from the group consisting of Phe, Trp, Tyr, and --NH--CHR.sub.1 --CO--, wherein R.sub.1 is hydrogen or alkyl from one to about six carbons; and X is a member selected from the group consisting of hydroxy, esterified hydroxy radicals, unsubstituted amino radicals and substituted amino radicals.

Abstract: Biologically active novel peptides and peptide-derivatives of the general formula: ##STR1## where A represents H-(L or D)Met, H-(L or D)Met(.fwdarw.O), H-(L or D)Met(.fwdarw.O.sub.2)desamino-Met, desamino-Met(.fwdarw.O),desamino-Met(.fwdarw.O.sub.2) or the group H.sub.2 N--B--CO--;B represents a branched or straight-chain alkylene (C.sub.1 -C.sub.6) or alkylidene (C.sub.1 -C.sub.6) group;Q represents the amino-acid residue --NH--CHR--CO--;R represents alkyl (C.sub.1 -C.sub.6), p-hydroxyphenylmethyl, 3-indolylmethyl or phenylmethyl;R.sub.1 and R.sub.2 represent hydrogen or an alkyl(1-6C) group, andZ represents N-(phenylalkyl)amino, N-(.beta.-indolylalkyl)amino, L-Trp-OH, L-Phe-OH, L-Trp-Gly-OH or L-Phe-Gly-OH, as well as the functional derivatives thereof.