Patents by Inventor David DiGiusto

David DiGiusto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA-BASED HIV INHIBITORS
    Publication number: 20160289681
    Abstract: Provided herein are, inter alia, antiviral recombinant nucleic acid compositions and methods of using the same. The recombinant nucleic acid compositions include nucleic acids encoding antiviral polycistronic RNAs, which are capable of inhibiting viral replication. The antiviral recombinant nucleic acid compositions provided herein are therefore particularly useful for therapeutic applications such as combinational HIV-1 gene therapy.
    Type: Application
    Filed: March 17, 2016
    Publication date: October 6, 2016
    Inventors: John Rossi, David DiGiusto, Janet Chung, Lisa Scherer
  • HUMANIZED MOUSE AND METHODS OF USING THE SAME
    Publication number: 20150342165
    Abstract: Provided herein, inter alia, is a humanized mouse with a gene-modified human hematopoietic stem and progenitor cell (GM-HSPC) graft, in which the HSPC cells within the graft are transduced with a gene vector, and gene vector includes a drug resistance gene or a disease treatment gene.
    Type: Application
    Filed: May 27, 2015
    Publication date: December 3, 2015
    Inventors: David DiGiusto, Angel Sheng Rui Gu
  • Method for producing a highly enriched population of hematopoietic stem cells
    Patent number: 5681559
    Abstract: The present invention provides a simple and reliable means for isolating populations of hematopoietic cells enriched for stem cell activity on the basis of possession of high CD34 cell surface antigen density ("CD34hi"). CD34.sup.hi cell preparations are useful, for example, for drug discovery efforts, for reconstituting hematopoiesis in an animal lacking a functioning hematopoietic system, and for gene therapies.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 28, 1997
    Assignee: Systemix, Inc.
    Inventors: David DiGiusto, Anne Galy