Abstract: Provided herein are genetically engineered cells containing one or more modulated metabolic genes, where the expression of the modulated metabolic gene(s) can be greater than that of an unmodified control. Also provided herein are methods of making the genetically engineered cells using synergistic activation mediator CRISPR-Cas9. Further provided herein are high throughput assays that can employ the genetically engineered cells provided herein.

Abstract: A portable physical medicine drop device for performing treatments upon a patient. The device includes powered mechanisms capable of lifting a portion of a patient from a surface, a housing for the mechanisms, and a control means to activate the pushing of a padded element toward the patient when the housing and mechanism are placed between the patient and a surface. Additional mechanisms having additional pads may be incorporated for various chiropractic and physical medicine procedures. A method of use of the portable device to perform treatments upon patients.

Abstract: A hybrid drive-thru door system that includes a door panel assembly movable between a plurality of operating modes. The door panel assembly includes a sliding door panel operable for movement between a closed position to at least partially cover a doorway opening and an opened position to at least partially expose the doorway opening. The sliding door panel has an upper sliding door panel member releasably attached to a lower sliding door panel member. The upper sliding door panel member is independently movable relative to the lower sliding door panel member in a window operating mode of the door panel assembly.

Abstract: A safety monitoring harness system for the protection of a climber is disclosed. Comprising the safety monitoring harness system comprising a base, an alarm system, a strap length sensor assembly, a PCB, a first tether assembly, a second tether assembly and a power system. The first tether assembly and the second tether assembly each comprise a strap, a retraction assembly, and an anchoring hook. The safety monitoring harness system is configured to selectively attach to the climber by: securing a harness assembly to the climber, and securing the base to the harness assembly. a portion of the retraction assembly for each of the first tether assembly and the second tether assembly are enclosed within the base. The anchoring hook retract and extend between a plurality of lengths from the base.

Abstract: A safety monitoring harness system for the protection of a climber comprising: said safety monitoring harness system comprising a base, a one or more tether assemblies, a retraction assembly, an alarm system, a strap length sensor assembly, and a power system. Said one or more tether assemblies comprising at least a first tether assembly and a second tether assembly. Said one or more tether assemblies each comprising a strap, and an anchoring hook. Said safety monitoring harness system is configured to selectively attach to said climber by: attaching a harness assembly to said climber, and securing said base to said harness assembly. A portion of said retraction assembly is enclosed within said base. Said retraction assembly are configured to selectively retract and release portions of said strap from within said base.

Abstract: A tether tracking system configured to secure and monitor a one or more tools to prevent drops and accidents by a worker. The tether tracking system comprises a base portion, a two or more straps, a one or more hooks, a tool strap and a one or more hook anchors. The two or more straps comprise at least a first strap and a second strap. The first strap comprises a first end and a second end. The second strap comprises a first end and a second end. The two or more straps are attached to the base portion with the second end of the first strap and the second end of the second strap attached to the base portion. The first end of the second strap is attached to the tool strap. The tool strap is configured to selectively attach to one among a one or more tool tethers.

Abstract: A tether tracking system configured to secure and monitor a one or more tools to prevent drops and accidents by a worker. The tether tracking system comprises a base portion, a two or more straps, a one or more hooks, a tool strap and a one or more hook anchors. The two or more straps comprise at least a first strap and a second strap. The first strap comprises a first end and a second end. The second strap comprises a first end and a second end. The two or more straps are attached to the base portion with the second end of the first strap and the second end of the second strap attached to the base portion. The first end of the second strap is attached to the tool strap. The tool strap is configured to selectively attach to one among a one or more tool tethers.

Abstract: A safety monitoring harness system for the protection of a climber comprising: said safety monitoring harness system comprising a base, a one or more tether assemblies, a retraction assembly, an alarm system, a strap length sensor assembly, and a power system. Said one or more tether assemblies comprising at least a first tether assembly and a second tether assembly. Said one or more tether assemblies each comprising a strap, and an anchoring hook. Said safety monitoring harness system is configured to selectively attach to said climber by: attaching a harness assembly to said climber, and securing said base to said harness assembly. A portion of said retraction assembly is enclosed within said base. Said retraction assembly are configured to selectively retract and release portions of said strap from within said base.

Abstract: Systems and methods for determining sweepstakes winners involve a display providing a code to an end-user device and the end user-device providing the displayed code to a computer, which determines whether the displayed code is a winning code. Whether a code is a winning code can be based on a variable factor, such as a geographic location, a date, a time of day, a day of a week, a number of submissions by a particular person, valued activities performed by a particular person. The identification of a code as a winning code can be performed either before the code is provided to the display or after the code is received by the computer.

Abstract: Various embodiments include an adjustable gas distribution assembly for an adjustable plasma spray device. In one embodiment, the assembly includes: a first gas distribution ring including a plurality of openings allowing a gas to pass to an inner diameter thereof, the first gas distribution ring including a mating surface upstream of the plurality of openings; and a positioning ring axially aligned with the gas distribution ring between the first gas distribution ring and an electrically charged outlet of the plasma spray device, wherein the positioning ring includes a mating surface that mates with the mating surface of the first gas distribution ring to form the gas distribution assembly, wherein the mating surface of the positioning ring is sized to mate with a plurality of distinct gas distribution rings including the first gas distribution ring.

Abstract: Various embodiments include an adjustable gas distribution assembly for an adjustable plasma spray device. In one embodiment, the assembly includes: a first gas distribution ring including a plurality of openings allowing a gas to pass to an inner diameter thereof, the first gas distribution ring including a mating surface upstream of the plurality of openings; and a positioning ring axially aligned with the gas distribution ring between the first gas distribution ring and an electrically charged outlet of the plasma spray device, wherein the positioning ring includes a mating surface that mates with the mating surface of the first gas distribution ring to form the gas distribution assembly, wherein the mating surface of the positioning ring is sized to mate with a plurality of distinct gas distribution rings including the first gas distribution ring.

Abstract: Systems and methods for determining sweepstakes winners involve a display providing a code to an end-user device and the end user-device providing the displayed code to a computer, which determines whether the displayed code is a winning code. Whether a code is a winning code can be based on a variable factor, such as a geographic location, a date, a time of day, a day of a week, a number of submissions by a particular person, valued activities performed by a particular person. The identification of a code as a winning code can be performed either before the code is provided to the display or after the code is received by the computer.

Abstract: A subset of unique codes is generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained of the secure server.

Abstract: A subset of unique codes are generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained therein.

Abstract: A subset of unique codes are generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained therein.

Abstract: A subset of unique codes are generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained therein.

Abstract: According to various embodiments, a portable cryogenic treatment system comprises a transportable housing. The transportable housing comprises a plurality of side walls, a front wall, a rear wall, a ceiling and a floor. The transportable housing includes a cryogenic liquid source and a cryogenic treatment chamber in fluid communication with the cryogenic liquid source. The cryogenic treatment chamber is configured to treat a treat able object using a cryogenic liquid.

Abstract: A subset of unique codes are generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained therein.

Abstract: A subset of unique codes are generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained therein.

Abstract: A subset of unique codes are generated from a set of codes. The subset of codes are stored in a database on a secure server and each of the codes is marked on a corresponding instantiation of the product. The marked instantiations are distributed. During their distribution, the marked instantiations are verified for authenticity and for routing. This verification is performed by reading or scanning the codes on the instantiations, and transmitting that information to the secure server for comparison against the codes and other information located in the database contained therein.