Abstract: Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.

Abstract: A cast iron piston characterized by a pearlitic matrix microstructure comprises a ring groove defined by opposed faces that are selectively hardened adjacent the piston side wall. The hardened surfaces are characterized by a martensitic matrix microstructure having a Knoop hardness of preferably at least 690. In a preferred embodiment, the groove faces are hardened by a stripe hardening process.

Abstract: An oil cooled piston particularly for two cycle direct injection diesel engines offers improved cooling through increasing of the combustion bowl rim radius and modifications to the understructure to provide alternate perforate gussets permitting an increased number of rim cooling ribs. An angular break from the rim radius to the squish land offsets efficiency impairment from the larger rim radius.