Patents by Inventor David E. Clarke

David E. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5436264
    Abstract: The present invention relates to novel N-aryloxyalkyl tryptamine .alpha..sub.1 -adrenergic receptor antagonists of the formula I: ##STR1## in which n is 2, 3 or 4; q is 1, 2 or 3; t is 0, 1, 2 or 3; z is 0, 1, 2 or 3; each R.sup.1 and R.sup.2 are independently hydroxy, halogen, cyano, (C.sub.1-8)alkyl, (C.sub.1-8)alkyloxy or trifluoromethyl; and R.sup.2 is hydrogen, (C.sub.1-4)alkyl, fluoro(C.sub.1-4)alkyl, difluoro(C.sub.1-4)alkyl, trifluoro(C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy(C.sub.1-4)alkyl, oxo(C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl or allyl or phenyl(C.sub.1-4)alkyl or heterocyclo(C.sub.1-8)alkyl (optionally substituted with one to two substituents independently selected from (C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy, trifluoromethyl and halogen); R.sup.3 and R.sup.4 are independently hydrogen, (C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl or allyl; and R.sup.5 is hydrogen, (C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl, allyl, (C.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: July 25, 1995
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Jurg R. Pfister, David E. Clarke
  • Patent number: 5380739
    Abstract: Compounds of the Formula (I), (II), or (III): ##STR1## wherein the variables are as defined in the specification and the pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin II antagonists.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: January 10, 1995
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Robin D. Clark, David E. Clarke, Lawrence E. Fisher, Alam Jahangir
  • Patent number: 5212195
    Abstract: Compound of the Formula (I), (II), or (III): ##STR1## wherein: R.sup.1 is lower alkyl or 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl;R.sup.2 is lower alkyl when R.sup.1 is 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl; or R.sup.2 is 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl when R.sup.1 is lower alkyl;R.sup.3 is hydrogen or lower alkyl;X is hydrogen, lower alkyl, halogen, --C(O)CF.sub.3, --CO.sub.2 R.sup.4, or --C(O)NR.sup.5 R.sup.6 ;Y is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, or --CO.sub.2 R.sup.4 ;Z is hydrogen, lower alkyl, lower alkoxy, or halogen; with the proviso that Y and Z cannot be attached to the nitrogen atom in Formula (II); whereinR.sup.4 is hydrogen or lower alkyl;R.sup.5 is hydrogen or lower alkyl;R.sup.6 is hydrogen or lower alkyl; orR.sup.5 and R.sup.6 taken together with the nitrogen to which they are attached represent a heterocycle;and pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin II antagonists.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: May 18, 1993
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Robin D. Clark, David E. Clarke, Lawrence E. Fisher, Alam Jahangir
  • Patent number: 4759868
    Abstract: A liquid general-purpose cleaner, having improved non-streak and cleaning properties, is obtained if in a liquid-compatible medium which comprises a nonionic surfactant, an at least partially esterified resin and water or a mixture of water and a water-miscible organic solvent, as nonionic a topped nonionic surfactant is used containing less than 2% by weight of non-alkoxylated material and less than 4% by weight of mono-alkoxylated material. By using this nonionic surfactant, less partially esterified resin and less perfume are required to achieve effects similar to those obtained when a non-topped nonionic surfactant is used.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: July 26, 1988
    Assignee: Lever Brothers Company
    Inventor: David E. Clarke
  • Patent number: 4741853
    Abstract: The present invention provides a solid bleaching block on the basis of an alkali metal monopersulphate for use in an in-cistern dispensing device, also comprising at least 5% by weight of an alkaline earth metal soap. By the use of these soaps, blocks are obtained which release the bleaching agent at an acceptable rate yet maintain their block structure.
    Type: Grant
    Filed: February 11, 1987
    Date of Patent: May 3, 1988
    Assignee: Lever Brothers Company
    Inventors: Adrian W. Walker, David E. Clarke
  • Patent number: 4555354
    Abstract: A detergent-containing water-insoluble closed bag is so constructed as to open and discharge its contents under mechanical action in a washing machine in use. The seams of the bag may be heat-sealed or cold pressure sealed such that at least one seam will burst open in use. The bag material may be porous with a pore size selected to minimize dusting of the detergent. The bag material may include a thermoplastic component to enable heat-sealing. The bag may contain conventional detergent compositions and/or other fabric treatment materials. These products give consumer benefits both by way of improved efficiency in the use of the detergent compositions and in greater convenience in use.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: November 26, 1985
    Assignee: Lever Brothers Company
    Inventors: David E. Clarke, James F. Davies, Colin Smart, John B. Tune
  • Patent number: 4554099
    Abstract: Thick and opaque general-purpose cleaning compositions having streak-free cleaning benefits are obtained by the use, in a composition comprising a nonionic detergent surfactant, an anionic detergent surfactant and an at least partially esterified resin, of a nonionic detergent surfactant with an HLB-value of between 3 and 10 and an anionic synthetic detergent in the form of its magnesium salt.
    Type: Grant
    Filed: April 18, 1984
    Date of Patent: November 19, 1985
    Assignee: Lever Brothers Company
    Inventor: David E. Clarke
  • Patent number: 4508635
    Abstract: A liquid general-purpose cleaner, having improved nonstreak and cleaning properties is obtained by inclusion, in a liquid compatible medium, of an at least 5% alcohol esterified resin copolymer and a nonionic surfactant having an HLB-value of between 10 and 15. The composition contains generally less than 5% of inorganic electrolyte salts, and can be applied to hard surfaces either in dilute form or neat.
    Type: Grant
    Filed: February 15, 1984
    Date of Patent: April 2, 1985
    Assignee: Lever Brothers Company
    Inventor: David E. Clarke
  • Patent number: 4448704
    Abstract: An article is disclosed which is suitable for wiping hard surfaces such as glass to give a streak-free finish. The article comprises a substrate (preferably paper or non-woven fabric) carrying a homogeneous aqueous composition having a surface tension below 45 mNm.sup.-1 and which on drying does not form discrete droplets or particles larger than 0.25 .mu.m. The liquid composition advantageously includes a (preferably nonionic) surface-active agent and a partially esterified resin such as a partially esterified styrene/maleic anhydride copolymer. The article may be wet (for example, coated or impregnated with the liquid composition) or dry up to the point of use (for example, the liquid may be within pressure-rupturable microcapsules). Preferably the article is produced by a process which includes prewashing the substrate to remove any potentially streak-forming impurities.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: May 15, 1984
    Assignee: Lever Brothers Company
    Inventors: Donald Barby, David E. Clarke, John Lloyd, Zia Haq
  • Patent number: 4394888
    Abstract: Extendable bridging bar frame members are pivotally mounted to an angularly adjustable loading platform level of a bi-elevational platform lift apparatus. The bridging bar frame members are selectively extendable to engage an associated dock side loading surface in order to suspend a free end non-attached portion of the loading platform at dock side level while the opposite end portion of the loading platform is adjusted for alignment with a vertically offset dock side. This will allow angular adjustment of the loading platform level while still utilizing the mechanical support of the bridging bar frame members.
    Type: Grant
    Filed: June 5, 1981
    Date of Patent: July 26, 1983
    Assignee: Advance Lifts, Inc.
    Inventor: David E. Clarke
  • Patent number: 4348293
    Abstract: A detergent product comprises a water-insoluble, water-permeable bag containing a particulate detergent composition, the bag material having a water-soluble or removable water-insoluble layer to protect the bag material from the composition and to reduce dusting. The protective layer may be coated on or impregnated into the bag material or may form a continuous layer laminated to the inside of the bag material or may be in the form of a separate inner bag. The water-soluble material may be soluble polyvinyl alcohol, polyethylene glycol, polysaccharide, alkali metal silicate, soap, nonionic detergent, gelatine, salts or esters of alginic acid. The removable water-insoluble material may be a silicone, a fatty acid, a water-insoluble cationic fabric softener, polyvinylacetate, insoluble polyvinyl alcohol, clay, zeolite, calcite, silica, titania or a wax. The bag material may be paper and/or plastics material such as polypropylene.
    Type: Grant
    Filed: July 14, 1980
    Date of Patent: September 7, 1982
    Assignee: Lever Brothers Company
    Inventors: David E. Clarke, James F. Davies, John B. Tune
  • Patent number: 4196093
    Abstract: Particulate detergent compositions comprising a detergent active compound, an alkali metal carbonate and finely divided calcium carbonate, are made by contacting the alkali metal carbonate in particulate form with a liquid or pasty detergent active compound or mixture thereof and admixing the calcium carbonate in powder form with the alkali metal carbonate particles so that the calcium carbonate adheres thereto.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: April 1, 1980
    Assignee: Lever Brothers Company
    Inventors: David E. Clarke, James F. Davies, John B. Tune, Raymond J. Wilde
  • Patent number: 4188304
    Abstract: A detergent product comprises a particulate detergent composition contained within a closed water-insoluble bag which has a water-sensitive seal, whereby the contents of the bag are discharged on contact of the bag with water. Use of such detergent products improves detergent dosage control and hence cost-effectiveness, and is particularly beneficial for detergent compositions of higher density than customary or which contain water-insoluble ingredients.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: February 12, 1980
    Assignee: Lever Brothers Company
    Inventors: David E. Clarke, James F. Davies, John B. Tune
  • Patent number: 4091906
    Abstract: A collapsible electric foot-toe guard is employed with a loading platform having electric controlled lift and descent movements, functioning as a safety device in the protection against unwitting protrusion of human limbs into the path of descent of the platform lift, said collapsible foot-toe guard being comprised of an outwardly depended contact plate moveably engaging a base support plate through hinge means to permit said contact plate with contact thereof to fold toward the base support plate, such folding movement effective to break a normally open, held closed electric limit switch circuit to arrest descent of the platform lift.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: May 30, 1978
    Assignee: Advance Lifts, Incorporated
    Inventors: David E. Clarke, Lawrence I. Richards
  • Patent number: 3967227
    Abstract: An actuator system for use in an electrical relay or the like. An actuator member is carried by a frame and is movable between a first and a second position, being biased toward its first position by a spring and having an actuating wire coupled between it and the frame. This wire is stretched from its original length to a second length by the spring when the actuator member is in its first position. The wire is of a selected metal alloy which, upon being heated, shortens its length and thus causes the tension in the wire to increase an amount sufficient to overcome the bias of the spring and to move the actuator member towards its second position.
    Type: Grant
    Filed: January 10, 1975
    Date of Patent: June 29, 1976
    Assignee: Texas Instruments Incorporated
    Inventors: David E. Clarke, Robert P. Lackey, Joel P. Clark
  • Patent number: 3959691
    Abstract: The disclosure relates to a manual reset motor protector device having an arm of a nickel-titanium metal alloy or the like supporting an electrical contact and having a spring arm supporting a second electrical contact, both of these arms being mounted on a device housing. A manual reset member is slidable on the housing for deforming the arm of the noted nickel-titanium metal alloy from an original configuration to a second configuration while the nickel-titanium alloy is below a predetermined transition temperature, whereby the device contacts are normally engaged to close a device circuit. When the device is mounted on a motor for protecting the motor against over-temperature conditions, electrical current is normally directed through the device circuit.
    Type: Grant
    Filed: April 16, 1973
    Date of Patent: May 25, 1976
    Assignee: Texas Instruments Incorporated
    Inventor: David E. Clarke