Patents by Inventor David E. Clarke
David E. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5436264Abstract: The present invention relates to novel N-aryloxyalkyl tryptamine .alpha..sub.1 -adrenergic receptor antagonists of the formula I: ##STR1## in which n is 2, 3 or 4; q is 1, 2 or 3; t is 0, 1, 2 or 3; z is 0, 1, 2 or 3; each R.sup.1 and R.sup.2 are independently hydroxy, halogen, cyano, (C.sub.1-8)alkyl, (C.sub.1-8)alkyloxy or trifluoromethyl; and R.sup.2 is hydrogen, (C.sub.1-4)alkyl, fluoro(C.sub.1-4)alkyl, difluoro(C.sub.1-4)alkyl, trifluoro(C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy(C.sub.1-4)alkyl, oxo(C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl or allyl or phenyl(C.sub.1-4)alkyl or heterocyclo(C.sub.1-8)alkyl (optionally substituted with one to two substituents independently selected from (C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy, trifluoromethyl and halogen); R.sup.3 and R.sup.4 are independently hydrogen, (C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl or allyl; and R.sup.5 is hydrogen, (C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl, allyl, (C.Type: GrantFiled: August 19, 1993Date of Patent: July 25, 1995Assignee: Syntex (U.S.A.) Inc.Inventors: Jurg R. Pfister, David E. Clarke
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Patent number: 5380739Abstract: Compounds of the Formula (I), (II), or (III): ##STR1## wherein the variables are as defined in the specification and the pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin II antagonists.Type: GrantFiled: February 4, 1993Date of Patent: January 10, 1995Assignee: Syntex (U.S.A.) Inc.Inventors: Robin D. Clark, David E. Clarke, Lawrence E. Fisher, Alam Jahangir
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Patent number: 5212195Abstract: Compound of the Formula (I), (II), or (III): ##STR1## wherein: R.sup.1 is lower alkyl or 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl;R.sup.2 is lower alkyl when R.sup.1 is 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl; or R.sup.2 is 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl when R.sup.1 is lower alkyl;R.sup.3 is hydrogen or lower alkyl;X is hydrogen, lower alkyl, halogen, --C(O)CF.sub.3, --CO.sub.2 R.sup.4, or --C(O)NR.sup.5 R.sup.6 ;Y is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, or --CO.sub.2 R.sup.4 ;Z is hydrogen, lower alkyl, lower alkoxy, or halogen; with the proviso that Y and Z cannot be attached to the nitrogen atom in Formula (II); whereinR.sup.4 is hydrogen or lower alkyl;R.sup.5 is hydrogen or lower alkyl;R.sup.6 is hydrogen or lower alkyl; orR.sup.5 and R.sup.6 taken together with the nitrogen to which they are attached represent a heterocycle;and pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin II antagonists.Type: GrantFiled: May 13, 1992Date of Patent: May 18, 1993Assignee: Syntex (U.S.A.) Inc.Inventors: Robin D. Clark, David E. Clarke, Lawrence E. Fisher, Alam Jahangir
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Patent number: 4759868Abstract: A liquid general-purpose cleaner, having improved non-streak and cleaning properties, is obtained if in a liquid-compatible medium which comprises a nonionic surfactant, an at least partially esterified resin and water or a mixture of water and a water-miscible organic solvent, as nonionic a topped nonionic surfactant is used containing less than 2% by weight of non-alkoxylated material and less than 4% by weight of mono-alkoxylated material. By using this nonionic surfactant, less partially esterified resin and less perfume are required to achieve effects similar to those obtained when a non-topped nonionic surfactant is used.Type: GrantFiled: April 16, 1987Date of Patent: July 26, 1988Assignee: Lever Brothers CompanyInventor: David E. Clarke
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Patent number: 4741853Abstract: The present invention provides a solid bleaching block on the basis of an alkali metal monopersulphate for use in an in-cistern dispensing device, also comprising at least 5% by weight of an alkaline earth metal soap. By the use of these soaps, blocks are obtained which release the bleaching agent at an acceptable rate yet maintain their block structure.Type: GrantFiled: February 11, 1987Date of Patent: May 3, 1988Assignee: Lever Brothers CompanyInventors: Adrian W. Walker, David E. Clarke
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Patent number: 4555354Abstract: A detergent-containing water-insoluble closed bag is so constructed as to open and discharge its contents under mechanical action in a washing machine in use. The seams of the bag may be heat-sealed or cold pressure sealed such that at least one seam will burst open in use. The bag material may be porous with a pore size selected to minimize dusting of the detergent. The bag material may include a thermoplastic component to enable heat-sealing. The bag may contain conventional detergent compositions and/or other fabric treatment materials. These products give consumer benefits both by way of improved efficiency in the use of the detergent compositions and in greater convenience in use.Type: GrantFiled: August 31, 1984Date of Patent: November 26, 1985Assignee: Lever Brothers CompanyInventors: David E. Clarke, James F. Davies, Colin Smart, John B. Tune
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Patent number: 4554099Abstract: Thick and opaque general-purpose cleaning compositions having streak-free cleaning benefits are obtained by the use, in a composition comprising a nonionic detergent surfactant, an anionic detergent surfactant and an at least partially esterified resin, of a nonionic detergent surfactant with an HLB-value of between 3 and 10 and an anionic synthetic detergent in the form of its magnesium salt.Type: GrantFiled: April 18, 1984Date of Patent: November 19, 1985Assignee: Lever Brothers CompanyInventor: David E. Clarke
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Patent number: 4508635Abstract: A liquid general-purpose cleaner, having improved nonstreak and cleaning properties is obtained by inclusion, in a liquid compatible medium, of an at least 5% alcohol esterified resin copolymer and a nonionic surfactant having an HLB-value of between 10 and 15. The composition contains generally less than 5% of inorganic electrolyte salts, and can be applied to hard surfaces either in dilute form or neat.Type: GrantFiled: February 15, 1984Date of Patent: April 2, 1985Assignee: Lever Brothers CompanyInventor: David E. Clarke
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Patent number: 4448704Abstract: An article is disclosed which is suitable for wiping hard surfaces such as glass to give a streak-free finish. The article comprises a substrate (preferably paper or non-woven fabric) carrying a homogeneous aqueous composition having a surface tension below 45 mNm.sup.-1 and which on drying does not form discrete droplets or particles larger than 0.25 .mu.m. The liquid composition advantageously includes a (preferably nonionic) surface-active agent and a partially esterified resin such as a partially esterified styrene/maleic anhydride copolymer. The article may be wet (for example, coated or impregnated with the liquid composition) or dry up to the point of use (for example, the liquid may be within pressure-rupturable microcapsules). Preferably the article is produced by a process which includes prewashing the substrate to remove any potentially streak-forming impurities.Type: GrantFiled: May 24, 1982Date of Patent: May 15, 1984Assignee: Lever Brothers CompanyInventors: Donald Barby, David E. Clarke, John Lloyd, Zia Haq
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Patent number: 4394888Abstract: Extendable bridging bar frame members are pivotally mounted to an angularly adjustable loading platform level of a bi-elevational platform lift apparatus. The bridging bar frame members are selectively extendable to engage an associated dock side loading surface in order to suspend a free end non-attached portion of the loading platform at dock side level while the opposite end portion of the loading platform is adjusted for alignment with a vertically offset dock side. This will allow angular adjustment of the loading platform level while still utilizing the mechanical support of the bridging bar frame members.Type: GrantFiled: June 5, 1981Date of Patent: July 26, 1983Assignee: Advance Lifts, Inc.Inventor: David E. Clarke
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Patent number: 4348293Abstract: A detergent product comprises a water-insoluble, water-permeable bag containing a particulate detergent composition, the bag material having a water-soluble or removable water-insoluble layer to protect the bag material from the composition and to reduce dusting. The protective layer may be coated on or impregnated into the bag material or may form a continuous layer laminated to the inside of the bag material or may be in the form of a separate inner bag. The water-soluble material may be soluble polyvinyl alcohol, polyethylene glycol, polysaccharide, alkali metal silicate, soap, nonionic detergent, gelatine, salts or esters of alginic acid. The removable water-insoluble material may be a silicone, a fatty acid, a water-insoluble cationic fabric softener, polyvinylacetate, insoluble polyvinyl alcohol, clay, zeolite, calcite, silica, titania or a wax. The bag material may be paper and/or plastics material such as polypropylene.Type: GrantFiled: July 14, 1980Date of Patent: September 7, 1982Assignee: Lever Brothers CompanyInventors: David E. Clarke, James F. Davies, John B. Tune
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Patent number: 4196093Abstract: Particulate detergent compositions comprising a detergent active compound, an alkali metal carbonate and finely divided calcium carbonate, are made by contacting the alkali metal carbonate in particulate form with a liquid or pasty detergent active compound or mixture thereof and admixing the calcium carbonate in powder form with the alkali metal carbonate particles so that the calcium carbonate adheres thereto.Type: GrantFiled: May 15, 1978Date of Patent: April 1, 1980Assignee: Lever Brothers CompanyInventors: David E. Clarke, James F. Davies, John B. Tune, Raymond J. Wilde
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Patent number: 4188304Abstract: A detergent product comprises a particulate detergent composition contained within a closed water-insoluble bag which has a water-sensitive seal, whereby the contents of the bag are discharged on contact of the bag with water. Use of such detergent products improves detergent dosage control and hence cost-effectiveness, and is particularly beneficial for detergent compositions of higher density than customary or which contain water-insoluble ingredients.Type: GrantFiled: May 15, 1978Date of Patent: February 12, 1980Assignee: Lever Brothers CompanyInventors: David E. Clarke, James F. Davies, John B. Tune
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Patent number: 4091906Abstract: A collapsible electric foot-toe guard is employed with a loading platform having electric controlled lift and descent movements, functioning as a safety device in the protection against unwitting protrusion of human limbs into the path of descent of the platform lift, said collapsible foot-toe guard being comprised of an outwardly depended contact plate moveably engaging a base support plate through hinge means to permit said contact plate with contact thereof to fold toward the base support plate, such folding movement effective to break a normally open, held closed electric limit switch circuit to arrest descent of the platform lift.Type: GrantFiled: February 28, 1977Date of Patent: May 30, 1978Assignee: Advance Lifts, IncorporatedInventors: David E. Clarke, Lawrence I. Richards
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Patent number: 3967227Abstract: An actuator system for use in an electrical relay or the like. An actuator member is carried by a frame and is movable between a first and a second position, being biased toward its first position by a spring and having an actuating wire coupled between it and the frame. This wire is stretched from its original length to a second length by the spring when the actuator member is in its first position. The wire is of a selected metal alloy which, upon being heated, shortens its length and thus causes the tension in the wire to increase an amount sufficient to overcome the bias of the spring and to move the actuator member towards its second position.Type: GrantFiled: January 10, 1975Date of Patent: June 29, 1976Assignee: Texas Instruments IncorporatedInventors: David E. Clarke, Robert P. Lackey, Joel P. Clark
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Patent number: 3959691Abstract: The disclosure relates to a manual reset motor protector device having an arm of a nickel-titanium metal alloy or the like supporting an electrical contact and having a spring arm supporting a second electrical contact, both of these arms being mounted on a device housing. A manual reset member is slidable on the housing for deforming the arm of the noted nickel-titanium metal alloy from an original configuration to a second configuration while the nickel-titanium alloy is below a predetermined transition temperature, whereby the device contacts are normally engaged to close a device circuit. When the device is mounted on a motor for protecting the motor against over-temperature conditions, electrical current is normally directed through the device circuit.Type: GrantFiled: April 16, 1973Date of Patent: May 25, 1976Assignee: Texas Instruments IncorporatedInventor: David E. Clarke