Patents by Inventor David E. Cliffel
David E. Cliffel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10444223Abstract: A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells includes a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; a sensor array coupled to the fluidic network; and a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.Type: GrantFiled: July 30, 2018Date of Patent: October 15, 2019Assignee: VANDERBILT UNIVERSITYInventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
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Publication number: 20190064144Abstract: A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells includes a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; a sensor array coupled to the fluidic network; and a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.Type: ApplicationFiled: July 30, 2018Publication date: February 28, 2019Inventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
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Patent number: 10119622Abstract: A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. The RPPM also includes a fluidic path in fluidic communication with first and second ports. The fluidic path is positioned under the actuator and coincident with the circular path, such that when the shaft of the actuator rotates, the plurality of rolling-members of the bearing assembly rolls along the fluidic path to cause a fluid to transfer between the first and second ports.Type: GrantFiled: November 29, 2017Date of Patent: November 6, 2018Assignee: VANDERBILT UNIVERSITYInventors: Frank E. Block, III, Philip C. Samson, Erik M. Werner, Dmitry A. Markov, Ronald S. Reiserer, Jennifer R. Mckenzie, David E. Cliffel, William J. Matloff, Frank E. Block, Jr., Joseph R. Scherrer, W. Hunter Tidwell, John P. Wikswo
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Patent number: 10078075Abstract: In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.Type: GrantFiled: December 10, 2012Date of Patent: September 18, 2018Assignee: VANDERBILT UNIVERSITYInventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
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Publication number: 20180080570Abstract: A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. The RPPM also includes a fluidic path in fluidic communication with first and second ports. The fluidic path is positioned under the actuator and coincident with the circular path, such that when the shaft of the actuator rotates, the plurality of rolling-members of the bearing assembly rolls along the fluidic path to cause a fluid to transfer between the first and second ports.Type: ApplicationFiled: November 29, 2017Publication date: March 22, 2018Inventors: Frank E. Block, III, Philip C. Samson, Erik M. Werner, Dmitry A. Markov, Ronald S. Reiserer, Jennifer R. Mckenzie, David E. Cliffel, William J. Matloff, Frank E. Block, JR., Joseph R. Scherrer, W. Hunter Tidwell, John P. Wikswo
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Patent number: 9874285Abstract: A platform for cultivation, maintenance, and/or analysis of one or more bio-objects includes one or more integrated bio-object microfluidics modules. Each integrated bio-object microfluidics module is configured to cultivate, maintain, analyze and/or mimic functionalities of a respective bio-object, and includes one or more on-chip pumps; a plurality of fluidic switches; and a microfluidic chip in fluid communication with the one or more on-chip pumps and the plurality of fluidic switches, having at least one chamber for accommodating the bio-object and a plurality of fluidic paths connecting the at least one chamber, the one or more on-chip pumps and the plurality of fluidic switches, and a power and control unit adapted for selectively and individually controlling the one or more on-chip pumps and the plurality of fluidic switches for performing bio-object microfluidics functions.Type: GrantFiled: November 20, 2013Date of Patent: January 23, 2018Assignee: VANDERBILT UNIVERSITYInventors: Frank E. Block, III, Philip C. Samson, Erik M. Werner, Dmitry A. Markov, Ronald S. Reiserer, Jennifer R. Mckenzie, David E. Cliffel, William J. Matloff, Frank E. Block, Jr., Joseph R. Scherrer, W. Hunter Tidwell, John P. Wikswo
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Patent number: 9725687Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.Type: GrantFiled: December 10, 2012Date of Patent: August 8, 2017Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, VANDERBILT UNIVERSITYInventors: John P. Wikswo, Philip C. Samson, Frank Emmanuel Block, III, Ronald S. Reiserer, Kevin Kit Parker, John A. McLean, Lisa Joy McCawley, Dmitry Markov, Daniel Levner, Donald E. Ingber, Geraldine A. Hamilton, Josue A. Goss, Robert Cunningham, David E. Cliffel, Jennifer Robin McKenzie, Anthony Bahinski, Christopher David Hinojosa
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Publication number: 20150298123Abstract: A platform for cultivation, maintenance, and/or analysis of one or more bio-objects includes one or more integrated bio-object microfluidics modules. Each integrated bio-object microfluidics module is configured to cultivate, maintain, analyze and/or mimic functionalities of a respective bio-object, and includes one or more on-chip pumps; a plurality of fluidic switches; and a microfluidic chip in fluid communication with the one or more on-chip pumps and the plurality of fluidic switches, having at least one chamber for accommodating the bio-object and a plurality of fluidic paths connecting the at least one chamber, the one or more on-chip pumps and the plurality of fluidic switches, and a power and control unit adapted for selectively and individually controlling the one or more on-chip pumps and the plurality of fluidic switches for performing bio-object microfluidics functions.Type: ApplicationFiled: November 20, 2013Publication date: October 22, 2015Inventors: Frank E. Block, III, Philip C. Samson, Erik M. Werner, Dmitry A. Markov, Ronald S. Reiserer, Jennifer R. Mckenzie, David E. Cliffel, William J. Matloff, Frank E. Block, Joseph R. Scherrer, W. Hunter Tidwell, John P. Wikswo
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Publication number: 20150004077Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.Type: ApplicationFiled: December 10, 2012Publication date: January 1, 2015Inventors: John P. Wikswo, Philip C. Samson, Frank Emmanuel Block, III, Ronald S. Reiserer, Kevin Kit Parker, John A. McLean, Lisa Joy McCawley, Dmitry Markov, Daniel Levner, Donald E. Ingber, Geraldine A. Hamilton, Josue A. Goss, Robert Cunningham, David E. Cliffel, Jennifer Robin McKenzie, Anthony Bahinski, Christopher David Hinojosa
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Publication number: 20140356849Abstract: In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.Type: ApplicationFiled: December 10, 2012Publication date: December 4, 2014Inventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
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Publication number: 20140042407Abstract: One aspect of the present disclosure relates to a biohybrid, photoelectrochemical energy conversion device including a first electrode, a second electrode, and a multilayer photoconductive organic film interposed between the first and second electrodes. The second electrode is formed from a semiconductor material. Each layer of the photoconductive organic film includes at least one light harvesting complex.Type: ApplicationFiled: July 29, 2013Publication date: February 13, 2014Applicant: Vanderbilt UniversityInventors: David E. Cliffel, Gabriel LeBlanc, G. Kane Jennings
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Patent number: 8003378Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: GrantFiled: March 5, 2009Date of Patent: August 23, 2011Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene LeBoeuf, Chang Y. Chung, David E. Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler