Patents by Inventor David E. McClure

David E. McClure has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aralkylaminoethanol heterocyclic compounds
    Patent number: 4816457
    Abstract: Heterocyclic aminoethanols of the formula:Het--CHOH--CH.sub.2 --NH-aralkylwhere Het is a 6-10 membered N-heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: June 30, 1987
    Date of Patent: March 28, 1989
    Inventors: John J. Baldwin, Joseph Atkinson, David E. McClure
  • Aralkylaminoethanol heterocyclic compounds
    Patent number: 4686222
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: August 11, 1987
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Substituted diazapines and derivatives thereof useful in the treatment of cardiovascular disorders
    Patent number: 4677102
    Abstract: There are disclosed novel diazapines and derivatives thereof which are useful in the treatment of cardiovascular disorders.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 30, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure, David A. Claremon
  • Substituted dihydroazepines useful as calcium channel blockers
    Patent number: 4677101
    Abstract: Substituted dihydroazepines, their preparation, and the use thereof as calcium channel blockers are disclosed.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: June 30, 1987
    Assignee: Merck & Co., Inc.
    Inventors: David A. Claremon, David E. McClure
  • Substituted pyrimidines useful as calcium channel blockers
    Patent number: 4675321
    Abstract: Pharmaceutical compositions of specific substituted pyrimidines and methods of treatment of certain cardiovascular disorders are disclosed. Also disclosed are novel substituted acrylated pyrimidines which are useful as calcium channel blockers.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 23, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Steven M. Pitzenberger, David E. McClure
  • (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
    Patent number: 4656168
    Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: October 13, 1983
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazoci ne(benzodiazocine)-11-carboxylates useful as calcium channel blockers
    Patent number: 4609494
    Abstract: Novel substituted and bridged pyrimidine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: September 2, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, David E. McClure
  • Preparation of epihalohydrin enantiomers
    Patent number: 4588824
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: May 13, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Aralkylaminoethanol heterocyclic compounds
    Patent number: 4568679
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals for reducing intraocular pressure, for use as .alpha.- and .beta.-and adrenergic blocking agents, as antihypertensive agents and for effecting bronchodilation.
    Type: Grant
    Filed: March 25, 1982
    Date of Patent: February 4, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Amino ketones and their preparation
    Patent number: 4533745
    Abstract: Amino ketone enantiomers and their direct preparation are disclosed. The ketone may be reduced to yield carbinol enantiomer which has pharmaceutical activity.
    Type: Grant
    Filed: December 8, 1980
    Date of Patent: August 6, 1985
    Assignee: Merck & Co., inc.
    Inventor: David E. McClure
  • Aralkylaminoethanol heterocyclic compounds
    Patent number: 4486446
    Abstract: Heterocyclicaminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere Het is a pyrone ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: December 4, 1984
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • (Aralkylamino-2-OR-propoxy)heterocyclic compounds
    Patent number: 4472427
    Abstract: Compounds of the formula Het--O--CH.sub.2 --CHOR--CH.sub.2 --NHaralkyl where Het are ##STR1## disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: August 30, 1982
    Date of Patent: September 18, 1984
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
    Patent number: 4442094
    Abstract: Compounds of the formula Het--O--CH.sub.2 --CHOR--CH.sub.2 --NH-aralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: February 22, 1982
    Date of Patent: April 10, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Method of use of enantiomers of trans-indeno[1,2-b]-1,4-oxazines
    Patent number: 4431647
    Abstract: The (R,R)-enantiomers of trans-indeno[1,2-b]-1,4-oxazines demonstrate dopaminergic activity, whereas the (S,S)-enantiomers demonstrate .alpha.-adrenergic antagonist activity. They are prepared by cyclization of the appropriate chiral 2-amino-1-hydroxyindane.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: February 14, 1984
    Assignee: Merck & Co., Inc.
    Inventor: David E. McClure
  • Preparation of epihalohydrin enantiomers
    Patent number: 4408063
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: October 4, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Aralkylamindethanol heterocyclic compounds
    Patent number: 4358455
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: November 9, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Benzoxazines
    Patent number: 4349673
    Abstract: Compounds of the formula Het--O--CH.sub.2 --CHOR--CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 14, 1982
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Preparation of epihalohydrin enantiomers
    Patent number: 4346042
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: August 24, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Aryloxypropanolamines
    Patent number: 4336261
    Abstract: Aryloxypropanolamines, their preparation and use as pharmaceuticals is disclosed.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: June 22, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Pyridyloxypropanolamines
    Patent number: 4210653
    Abstract: Pyridyloxypropanolamines, their preparation and use as antihypertensive agents is disclosed.
    Type: Grant
    Filed: June 27, 1978
    Date of Patent: July 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure