Patents by Inventor David Edward Birch

David Edward Birch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid amplification using a reversibly inactivated thermostable enzyme
    Patent number: 5773258
    Abstract: The present invention provides methods for the amplification of nucleic acids using a reversibly inactivated thermostable enzyme. The reversibly inactivated enzyme is the result of a chemical modification of the protein which inactivates the enzyme. The activity of the inactivated enzyme is recovered by an incubation of the reaction mixture at an elevated temperature prior to, or as part of, the amplification reaction. Non-specific amplification is reduced because the reaction mixture does not support the formation of extension products prior to the activating incubation.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: June 30, 1998
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Edward Birch, Walter Joseph Laird, Michael Anthony Zoccoli
  • Nucleic acid amplification using a reersibly inactivated thermostable enzyme
    Patent number: 5677152
    Abstract: The present invention provides methods for the amplification of nucleic acids using a reversibly inactivated thermostable enzyme. The reversibly inactivated enzyme is the result of a chemical modification of the protein which inactivates the enzyme. The activity of the inactivated enzyme is recovered by an incubation of the reaction mixture at an elevated temperature prior to, or as part of, the amplification reaction. Non-specific amplification is reduced because the reaction mixture does not support the formation of extension products prior to the activating incubation.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: October 14, 1997
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Edward Birch, Walter Joseph Laird, Michael Anthony Zoccoli