Patents by Inventor David F. Wiemer
David F. Wiemer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11926641Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful in immunotherapy as a potential treatment, or co-treatment, for cancer or infectious diseases.Type: GrantFiled: March 15, 2019Date of Patent: March 12, 2024Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: David F. Wiemer, Andrew J. Wiemer
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Publication number: 20210115074Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful in immunotherapy as a potential treatment, or co-treatment, for cancer or infectious diseases.Type: ApplicationFiled: March 15, 2019Publication date: April 22, 2021Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, UNIVERSITY OF CONNECTICUTInventors: David F. Wiemer, Andrew J. Wiemer
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Patent number: 10814006Abstract: The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the phosphate, phosphonate, carboxy, or phosphoramidate group to form the corresponding ester and salts thereof. The conjugates are useful for therapy and as probes. The invention also provides therapeutic methods for treating diseases with conjugates of the invention as well as methods for determining optimal dosages of a conjugate or a therapeutic agent for a given patient using a conjugate of the invention.Type: GrantFiled: July 14, 2016Date of Patent: October 27, 2020Assignees: University of Iowa Research Foundation, University of ConnecticutInventors: David F. Wiemer, Rocky J. Barney, Andrew Wiemer
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Publication number: 20180207284Abstract: The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the phosphate, phosphonate, carboxy, or phosphoramidate group to form the corresponding ester and salts thereof. The conjugates are useful for therapy and as probes.Type: ApplicationFiled: July 14, 2016Publication date: July 26, 2018Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, UNIVERISTY OF CONNECTICUTInventors: David F. Wiemer, Rocky J. Barney, Andrew Wiemer
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Publication number: 20170107173Abstract: Compounds of formula I: and salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating various diseases and conditions.Type: ApplicationFiled: October 14, 2016Publication date: April 20, 2017Inventors: David F. Wiemer, Jeffrey D. Neighbors
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Patent number: 9428493Abstract: The invention provides a compound of formula (I): wherein R1-R5 have any of the values defined in the specification. The compounds are useful for the treatment of cancer and other diseases.Type: GrantFiled: March 25, 2013Date of Patent: August 30, 2016Assignee: University of Iowa Research FoundationInventors: John Kodet, Jeffrey D. Neighbors, David F. Wiemer
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Publication number: 20150045404Abstract: The invention provides a compound of formula (I): wherein R1-R5 have any of the values defined in the specification. The compounds are useful for the treatment of cancer and other diseases.Type: ApplicationFiled: March 25, 2013Publication date: February 12, 2015Inventors: John Kodet, Jeffrey D. Neighbors, David F. Wiemer
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Patent number: 8637685Abstract: The invention provides fluorescent schweinfurthin analogs of formula (I) which are useful as probes and for the treatment of cancer and other diseases.Type: GrantFiled: June 25, 2009Date of Patent: January 28, 2014Assignee: University of Iowa Research FoundationInventors: David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
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Publication number: 20110319481Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.Type: ApplicationFiled: January 26, 2011Publication date: December 29, 2011Applicants: Government of the United States of America, National Institute of Health, University of Iowa Research FoundationInventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
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Publication number: 20110160297Abstract: The invention provides fluorescent schweinfurthin analogs of formula(I) which are useful as probes and for the treatment of cancer and other diseases.Type: ApplicationFiled: June 25, 2009Publication date: June 30, 2011Applicant: University of Iowa Research FoundationInventors: David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
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Patent number: 7902228Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.Type: GrantFiled: February 4, 2008Date of Patent: March 8, 2011Assignees: University of Iowa Research Foundation, The United States of America, National Institute of HealthInventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
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Publication number: 20100240612Abstract: The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides novel compounds of formula I as well as salts and prodrugs thereof.Type: ApplicationFiled: March 22, 2010Publication date: September 23, 2010Applicant: University of Iowa Research FoundationInventors: David F. Wiemer, Rocky J. Barney, Raymond J. Hohl
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Publication number: 20080227852Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.Type: ApplicationFiled: February 4, 2008Publication date: September 18, 2008Inventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
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Patent number: 7358377Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.Type: GrantFiled: March 29, 2005Date of Patent: April 15, 2008Assignees: University of Iowa Research Foundation, The United States of AmericaInventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
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Publication number: 20080015232Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.Type: ApplicationFiled: March 29, 2005Publication date: January 17, 2008Inventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
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Patent number: 7268124Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.Type: GrantFiled: August 25, 2005Date of Patent: September 11, 2007Assignee: University of Iowa Research FoundationInventors: David F. Wiemer, Raymond J. Hohl