Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.

Abstract: Disclosed herein is an electrode assembly, comprising in a stacked manner a first anode layer, an anode current collector layer, a second anode layer, a separator layer, a first cathode layer, a cathode current collector layer, and a second cathode layer. In the electrode assembly, the anode current collector layer and/or the cathode current collector layer comprises at least two conductive layers wherein between neighbouring pairs of conductive layers, a respective heat spreading layer is interposed.

Abstract: The application relates to a method of a predicting the presence of invasive pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis and a broad spectrum of tumor suppressor gene linked microsatellite LOH. Methods of diagnosing, determining prognosis of and determining a course of treatment for pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions are also provided.

Abstract: A surgical site barrier which is smaller and provides for a sanitized area surrounding a surgical site or other wound, but which does not necessarily encompass the entire room or patient. Device is designed to site in close proximity to the patient and provide a frame with an opening where objects passing through the opening will first pass through an electromagnetic radiation (EMR) light wall and/or through an outward directed laminar airflow before being able to contact the wound.

Abstract: Disclosed herein are methods of accurately measuring carcinoembryonic antigen in a biological sample and methods of identifying and treating a mucinous cyst in a subject.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.

Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. In some embodiments, the secure circuit is configured to generate a public key and a private key for an application, and receive, from the application via an API, a request to perform a cryptographic operation using the private key. The secure circuit is further configured to perform the cryptographic operation in response to the request.

Abstract: Disclosed herein are methods of accurately measuring carcinoembryonic antigen in a biological sample and methods of identifying and treating a mucinous cyst in a subject.

Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.

Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.

Abstract: The application relates to a method of a predicting the presence of invasive pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis and a broad spectrum of tumor suppressor gene linked microsatellite LOH. Methods of diagnosing, determining prognosis of and determining a course of treatment for pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions are also provided.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.

Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. In some embodiments, the secure circuit is configured to generate a public key and a private key for an application, and receive, from the application via an API, a request to perform a cryptographic operation using the private key. The secure circuit is further configured to perform the cryptographic operation in response to the request.

Abstract: Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.