Patents by Inventor David Frederick Mercer

David Frederick Mercer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
    Patent number: 8445745
    Abstract: The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: May 21, 2013
    Assignee: KMT Hepatech, Inc.
    Inventors: Norman M. Kneteman, D. Lorne Tyrrell, David Frederick Mercer
  • Animal Model Having a Chimeric Human Liver and Suceptible to Human Hepatitis C Virus Infection
    Publication number: 20120309032
    Abstract: The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
    Type: Application
    Filed: May 30, 2012
    Publication date: December 6, 2012
    Inventors: Norman M. Kneteman, D. Lorne Tyrrell, David Frederick Mercer
  • Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
    Patent number: 8212106
    Abstract: The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: July 3, 2012
    Assignee: KMT Hepatech, Inc.
    Inventors: Norman M. Kneteman, D. Lorne Tyrrell, David Frederick Mercer
  • Animal Model Having a Chimeric Human Liver and Suceptible to Human Hepatitis C Virus Infection
    Publication number: 20110167507
    Abstract: The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
    Type: Application
    Filed: July 20, 2010
    Publication date: July 7, 2011
    Inventors: Norman M. Kneteman, D. Lorne Tyrrell, David Frederick Mercer
  • Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
    Patent number: 7781642
    Abstract: The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: August 24, 2010
    Assignee: KMT Hepatech, Inc.
    Inventors: Norman M. Kneteman, D. Lorne Tyrrell, David Frederick Mercer
  • Animal Model Having a Chimeric Human Liver and Susceptible to Human Hepatitis C Virus Infection
    Publication number: 20090151012
    Abstract: The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
    Type: Application
    Filed: December 11, 2008
    Publication date: June 11, 2009
    Inventors: NORMAN M. KNETEMAN, D. Lorne Tyrrell, David Frederick Mercer