Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Abstract: The present invention relates generally to a new family of antennas with a multiband behaviour and a reduced size. The general configuration of the antenna consists of a multilevel structure which provides the multiband behaviour, combined with a multilevel and/or space-filling ground-plane. The multilevel structure consists of two arms of different length that follow a winding parallel path spaced by a winding parallel gap (parallel to the arms) with a substantially similar shape as each of said arms, that is, with a similar winding path as the arms. The resulting antenna covers the major current and future wireless services, opening this way a wide range of possibilities in the design of universal, multi-purpose, wireless terminals and devices.

Abstract: The present invention provides genotyping analysis by liquid chromatographic analysis of short nucleic acid fragments. The nucleic acid fragments are amplification products using specifically designed oligonucleotides as primers and target nucleic acids containing nucleotides of interest as templates. The oligonucleotides contain recognition sequences for restriction endonucleases that cleave outside the recognition sequences. The short nucleic acid fragments can be rapidly and reliably analyzed using liquid chromatography, optionally followed by mass spectrometry, and the nucleotides of interest identified.