Abstract: Provided are specific leukotriene synthesis inhibitor compounds and pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions in treating, for example, inflammatory diseases or conditions.

Abstract: A method includes executing an application at a mobile device to provide a graphical user interface and interact with a content server to display an image stored at the content server on a display of the mobile device; while displaying the image, receiving a first user input for a first annotation to the image based on user interaction with the graphical user interface, the first user input indicating a first region of the image; based on the first user input, displaying a text entry box together with a selection box in the graphical user interface, the selection box defining a region of the image with which the first annotation is to be associated; receiving a first comment via the text entry box; and responsive to second user input, sending the first comment and a location of the selection box to the content server for storage as the first annotation.

Abstract: A method includes executing an application at a mobile device to provide a graphical user interface and interact with a content server to display an image stored at the content server on a display of the mobile device; while displaying the image, receiving a first user input for a first annotation to the image based on user interaction with the graphical user interface, the first user input indicating a first region of the image; based on the first user input, displaying a text entry box together with a selection box in the graphical user interface, the selection box defining a region of the image with which the first annotation is to be associated; receiving a first comment via the text entry box; and responsive to second user input, sending the first comment and a location of the selection box to the content server for storage as the first annotation.

Abstract: A production method of genomic DNA in which a deletion of more than 100 bases of nucleotides is introduced into a target region of the genomic DNA, the method includes a contact step of bringing a type I CRISPR associated complex for anti-viral defense (type I Cascade complex), CRISPR RNA (crRNA), and Cas3 protein into contact with the genomic DNA.

Abstract: A method includes executing an application at a mobile device to provide a graphical user interface and interact with a content server to display an image stored at the content server on a display of the mobile device; while displaying the image, receiving a first user input for a first annotation to the image based on user interaction with the graphical user interface, the first user input indicating a first region of the image; based on the first user input, displaying a text entry box together with a selection box in the graphical user interface, the selection box defining a region of the image with which the first annotation is to be associated; receiving a first comment via the text entry box; and responsive to second user input, sending the first comment and a location of the selection box to the content server for storage as the first annotation.

Abstract: A virus-like particle encapsulating a target protein is provided. The virus-like particle contain a Gag protein, and the Gag protein forms a dimer with the target protein.

Abstract: A method includes executing an application at a mobile device to provide a graphical user interface and interact with a content server to display an image stored at the content server on a display of the mobile device; while displaying the image, receiving a first user input for a first annotation to the image based on user interaction with the graphical user interface, the first user input indicating a first region of the image; based on the first user input, displaying a text entry box together with a selection box in the graphical user interface, the selection box defining a region of the image with which the first annotation is to be associated; receiving a first comment via the text entry box; and responsive to second user input, sending the first comment and a location of the selection box to the content server for storage as the first annotation.

Abstract: A method includes executing an application at a mobile device to provide a graphical user interface and interact with a content server to display an image stored at the content server on a display of the mobile device; while displaying the image, receiving a first user input for a first annotation to the image based on user interaction with the graphical user interface, the first user input indicating a first region of the image; based on the first user input, displaying a text entry box together with a selection box in the graphical user interface, the selection box defining a region of the image with which the first annotation is to be associated; receiving a first comment via the text entry box; and responsive to second user input, sending the first comment and a location of the selection box to the content server for storage as the first annotation.

Abstract: A computing device displays electronic content associated with a plurality of annotations each corresponding to a respective portion of the electronic content. A first annotation, which includes one or more comments associated with a first portion of the electronic content, is displayed. While the first annotation is displayed, an input to display a second annotation is received. The second annotation is associated with a second portion of the electronic content, and includes one or more comments associated with the second portion. Responsive to receiving the input, the second portion of the electronic content and the one or more comments associated with the second portion are displayed.

Abstract: A computing device displays electronic content associated with a plurality of annotations each corresponding to a respective portion of the electronic content. A first annotation, which includes one or more comments associated with a first portion of the electronic content, is displayed. While the first annotation is displayed, an input to display a second annotation is received. The second annotation is associated with a second portion of the electronic content, and includes one or more comments associated with the second portion. Responsive to receiving the input, the second portion of the electronic content and the one or more comments associated with the second portion are displayed.

Abstract: Methods and systems are provided for dynamically generating and displaying a list of contacts. In accordance with one implementation, a method is provided that includes identifying one or more contacts having associated contact information. The one or more contacts may be associated with a user and identified across a plurality of information services or sources. The method further includes determining a subset of the one or more contacts and associated contact information based on a set of predefined criteria, generating a list of the subset of contacts and associated contact information, and displaying the generated list of contacts and associated contact information on the user interface.

Abstract: A turbomachine comprising a housing defining a bearing cavity and a turbine chamber separated by a first wall, a heat shield disposed between the first wall and the turbine wheel, a heat shield cavity defined between the first wall and the heat shield. The shaft extends through a passage defined in part by a first aperture in the wall and a second aperture in the heat shield. A first seal is provided between the shaft and the first aperture. The housing defines a first gas channel communicating with the heat shield cavity for connection to a pressure source for raising pressure within the heat shield cavity. A second channel is provided between the heat shield cavity and the passage, the second channel opening to the passage on the opposite side of the first seal to the bearing assembly. A second seal is provided between the shaft and the second aperture.

Abstract: A first file is received. The first file has a first format. The first file includes information associated with an item. The information is extracted from the first file. The extracted information is mapped to a capability profile.

Abstract: A turbomachine comprises a housing (71) defining a bearing cavity (71) and a turbine chamber (77a) separated by a first wall. A heat shield (72) is disposed between the first wall and the turbine wheel (77), a heat shield cavity (78) being defined between the first wall and the heat shield (72). The shaft (81) extends through a passage (85) defined at least in part by a first aperture (86) in said wall and a second aperture (87) in the heat shield (72). A first seal (88) is provided between the shaft (81) and said first aperture (86). The housing defines a first gas channel (79) communicating with the heat shield cavity (78) for connection to a pressure source for raising pressure within the heat shield cavity (78). A second channel (92) is provided between the heat shield cavity (78) and said passage (85), the second channel opening to said passage (85) on the opposite side of said first seal (88) to said bearing assembly (82).

Abstract: Methods, systems, and computer program products for dynamically generating and displaying a contacts list for one or more services of a computing system. The method comprises identifying one or more contacts having associated contact information, the one or more contacts being associated with a user of the computing system, wherein the one or more contacts are identified across one or more information services or sources associated with the computing system; determining a subset of the one or more contacts and associated contact information based on a set of predefined criteria; generating a list of the subset of contacts and associated contact information; and displaying the generated list of contacts and associated contact information on the user interface.

Abstract: A quantity of an item referenced within a multilevel bill of material (BOM) is determined. A price bid for the item is received into an application framework from a supplier. The price bid is associated with the item. The cost of the multilevel BOM is determined based on the quantity of the item and the price bid.

Abstract: Methods, systems, and computer program products for dynamically generating and displaying a contacts list for one or more services of a computing system. The method may include identifying one or more contacts having associated contact information. The contacts may be associated with a user of the computing system and may be identified across one or more information services or sources associated with the computing system. The method may also include determining a subset of the contacts and associated contact information based on a set of predefined criteria; generating a list of the subset of contacts and associated contact information; and displaying the generated list of contacts and associated contact information on a user interface.

Abstract: An oil control device inhibits the flow of oil along a shaft (8) rotating about an axis. The oil control device comprises an annular body (19) for rotation with said shaft (8) and includes a first face (30) extending generally radially from said axis. A second radially outer circumferential surface (40) is provided, extending generally axially. An oil slinging groove (32) extends into said body (19) and has a mouth (37) defined between a first circumferentially extending rim (38) and a second circumferentially extending rim (39). The second rim (39) is spaced both radially and axially from the first rim (38). The groove (32) is defined at least in part by a wall (34) which meets the first rim (38) at an acute angle to a radial plane. The groove (32) is also defined at least in part by a wall (35) which meets the second rim (39) at an acute angle to the direction of the axis.

Abstract: A first file is received in a first format. The first format is determined. A converter is selected based on the first format. Using the converter, the first file is translated to at least one second file. The second file has a second format.

Abstract: A turbomachine comprises a housing (71) defining a bearing cavity (71) a and a turbine chamber (77a) separated by a first wall. A heat shield (72) is disposed between the first wall and the turbine wheel (77), a heat shield cavity (78) being defined between the first wall and the heat shield (72). The shaft (81) extends through a passage (85) defined at least in part by a first aperture (86) in said wall and a second aperture (87) in the heat shield (72). A first seal (88) is provide between the shaft (81) and said first aperture (86). The housing defines a first gas channel (79) communicating with the heat shield cavity (78) for connection to a pressure source for raising pressure within the heat shield cavity (78). A second channel (92) is provided between the heat shield cavity (78) and said passage (85), the second channel opening to said passage (85) on the opposite side of said first seal (88) to said bearing assembly (82).