Patents by Inventor David George Sanford

David George Sanford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable analogs of peptide and polypeptide therapeutics
    Patent number: 9102756
    Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: August 11, 2015
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, David George Sanford
  • Stabilized GLP-1 analogs
    Patent number: 8318668
    Abstract: Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1-like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1. Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1 fragment in which the amino acid residue in the base amino acid sequence corresponding to the P?1 residue of GLP-1 is an amino acid analog having a tetrasubstituted C? carbon; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have the properties indicated above. The invention also includes methods of treatment where these analogs are administered.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: November 27, 2012
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, David George Sanford
  • Stable Analogs of Peptide and Polypeptide Therapeutics
    Publication number: 20120130044
    Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
    Type: Application
    Filed: August 9, 2011
    Publication date: May 24, 2012
    Applicant: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, David George Sanford
  • Long-Acting GLP-1 Derivatives, and Methods of Treating Cardiac Dysfunction
    Publication number: 20110245173
    Abstract: The present invention generally provides polypeptide analogues of GLP-‘(9-34) and GLP-1 (9-36) that have increased in vivo half-lives resulting from reduced susceptibility to proteolytic enzymes. Other aspects of the invention relate to methods of using the polypeptide analogues described herein for treating cardiac dysfunction and other heart-related maladies. Yet another aspect of the present invention relates lo formulations comprising the polypeptide analogues described herein.
    Type: Application
    Filed: June 3, 2009
    Publication date: October 6, 2011
    Inventors: William W. Bachovchin, Hung-sen Lai, David George Sanford
  • Stable analogs of peptide and polypeptide therapeutics
    Patent number: 7994121
    Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: August 9, 2011
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-Sen Lai, David George Sanford
  • Stabilized GLP-1 Analogs
    Publication number: 20090306338
    Abstract: Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1-like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1. Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1 fragment in which the amino acid residue in the base amino acid sequence corresponding to the P?1 residue of GLP-1 is an amino acid analog having a tetrasubstituted C? carbon; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have the properties indicated above. The invention also includes methods of treatment where these analogs are administered.
    Type: Application
    Filed: September 7, 2006
    Publication date: December 10, 2009
    Applicant: Trustees of Tufts College
    Inventors: William W. Bachovchin, David George Sanford
  • Stable analogs of peptide and polypeptide therapeutics
    Patent number: 7259234
    Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: August 21, 2007
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-sen Lai, David George Sanford