Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.

Abstract: Methods of treating subjects having clonal hematopoiesis of indeterminate potential (CHIP) with lymphocyte antigen 75 (LY75), Cluster of Differentiation 164 (CD164), or Poly(ADP-Ribose) Polymerase 1 (PARP1) inhibitors, and methods of identifying subjects having an increased risk of developing CHIP are provided herein.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

Abstract: An unmanned and self-powered vehicle or Towable Autonomous Dray (TOAD) may follow a vehicle and tow a trailer, haul a load, and/or recharge a pilot vehicle. The TOAD may be semi-autonomous and may attach to a pilot vehicle by an electronic identification. Further, wireless charging of the pilot vehicle may be provided by the TOAD. Smart trailer brakes, electric trailer axles, and a mechanically coupled tow vehicle may be provided by the TOAD in combination with additional units. A smart trailer controller may include a smart head unit and a smart tail unit in a trailer that may offer trailer security and increased safety. A smart trailer brake controller on the pilot vehicle and a smart module on the trailer may be applied where no unmanned vehicle is employed, such as, in a classic pick-up/trailer combination.

Abstract: The present invention provides methods for preventing and treating cardiac dysfunction, including cardiomyopathy and heart failure. The methods of the invention feature the administration of an antagonist of Activin A, e.g., a therapeutically effective amount of an antibody that binds to and reduces or neutralizes the activity of human Activin A. The methods of the invention are useful in preventing and treating cardiac disease from multiple causes, including viral disease, e.g., COVID-19.

Abstract: A food and beverage preparation system and method for the precision wiping of plates and glassware in restaurants and bars including one or more cylindrically shaped fiber rolls having flat ends and a sanitary dispensing means for the one or more cylindrically shaped fiber rolls. A dry use method involves removing a cylindrical shaped fiber roll from a sanitary dispenser, grasping the fiber roll in a manner conducive to precision wiping, wiping a specific area of a plate or other surface and discarding the cylindrical shaped fiber roll when done. A wet use method involves wetting or dampening the cylindrical shaped fiber rolls in specialized liquids and grasping the fiber roll in a manner conducive to precision wiping, wiping a specific area of a plate or other surface and discarding the cylindrical shaped fiber roll when done.

Abstract: The present invention relates to a combination comprising (a) RAD001, or a pharmaceutically acceptable salt thereof, and (b) BEZ235, or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential use for enhancement of an immune response; a pharmaceutical composition comprising such combination; a method of enhancing immune response in a subject comprising administration of said combination to a subject in need thereof; use of such combination for preparation of a medicament for the enhancement of an immune response; and a commercial package thereto.

Abstract: The provision of dual mode services is facilitated. Access to the dual mode services is controlled by associating a mobile device to an access point. Subscribers are required to provide valid geographical addresses for access points associated with the mobile devices prior to provision of service. Consequently, physical addresses are necessarily available for emergency services (e.g., E911). Mobile devices are restricted to specific access points based upon the access point identifiers automatically provided during initialization of service and maintained for authorization purposes.

Abstract: The present invention relates to a combination comprising (a) RAD001, or a pharmaceutically acceptable salt thereof, and (b) BEZ235, or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential use for enhancement of an immune response; a pharmaceutical composition comprising such combination; a method of enhancing immune response in a subject comprising administration of said combination to a subject in need thereof; use of such combination for preparation of a medicament for the enhancement of an immune response; and a commercial package thereto.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.

Abstract: The present invention relates, in part, to compositions and methods for enhancement of an immune response by partial mTOR inhibition, e.g., with low, immune enhancing, doses of an mTOR inhibitor, such as RAD001.

Abstract: An unmanned and self-powered vehicle or Towable Autonomous Dray (TOAD) may follow a vehicle and tow a trailer, haul a load, and/or recharge a pilot vehicle. The TOAD may be semi-autonomous and may attach to a pilot vehicle by an electronic identification. Further, wireless charging of the pilot vehicle may be provided by the TOAD. Smart trailer brakes, electric trailer axles, and a mechanically coupled tow vehicle may be provided by the TOAD in combination with additional units. A smart trailer controller may include a smart head unit and a smart tail unit in a trailer that may offer trailer security and increased safety. A smart trailer brake controller on the pilot vehicle and a smart module on the trailer may be applied where no unmanned vehicle is employed, such as, in a classic pick-up/trailer combination.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.

Abstract: The provision of dual mode services is facilitated. Access to the dual mode services is controlled by associating a mobile device to an access point. Subscribers are required to provide valid geographical addresses for access points associated with the mobile devices prior to provision of service. Consequently, physical addresses are necessarily available for emergency services (e.g., E911). Mobile devices are restricted to specific access points based upon the access point identifiers automatically provided during initialization of service and maintained for authorization purposes.

Abstract: The present invention relates, in part, to compositions and methods for enhancement of an immune response by partial mTOR inhibition, e.g., with low, immune enhancing, doses of an mTOR inhibitor, such as RAD001.

Abstract: The provision of dual mode services is facilitated. Access to the dual mode services is controlled by associating a mobile device to an access point. Subscribers are required to provide valid geographical addresses for access points associated with the mobile devices prior to provision of service. Consequently, physical addresses are necessarily available for emergency services (e.g., E911). Mobile devices are restricted to specific access points based upon the access point identifiers automatically provided during initialization of service and maintained for authorization purposes.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: The present invention relates, in part, to compositions and methods for enhancement of an immune response by partial mTOR inhibition, e.g., with low, immune enhancing, doses of an mTOR inhibitor, such as RAD001.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to the methods of preconditioning a subject, e.g., by depleting B cells in combination with the use of a cell comprising a chimeric antigen receptor (CAR) that targets a tumor antigen as described herein. The methods for preconditioning the subject described herein include using a cell comprising a CAR that targets a B cell antigen as described herein.