Abstract: Disclosed herein are non-naturally occurring vesicle comprising a chimeric vesicle localization moiety comprising a surface-and-transmembrane domain of a first vesicle localization moiety and a cytosolic domain of a second vesicle localization moiety, the method of making said vesicle and uses thereof.

Abstract: The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.

Abstract: Disclosed herein are non-naturally occurring vesicle comprising a chimeric vesicle localization moiety comprising a surface-and-transmembrane domain of a first vesicle localization moiety and a cytosolic domain of a second vesicle localization moiety, the method of making said vesicle and uses thereof.

Abstract: Disclosed herein are non-naturally occurring vesicle comprising a chimeric vesicle localization moiety comprising a surface-and-transmembrane domain of a first vesicle localization moiety and a cytosolic domain of a second vesicle localization moiety, the method of making said vesicle and uses thereof.

Abstract: The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.

Abstract: The present invention is a cosmetic massage and liquid distributing electronic mask or electronic cosmetic apparatus utilized for skin health. The present invention presents a unique way for users to engage in a hands-free massage in conjunction with cosmetic skincare products to maintain healthy skin appearance. The said cosmetic apparatus lifts and firms the skin, and increases collagen production to areas of the face and neck to renew the skin.

Abstract: The present invention provides compositions and methods for treating KMA-expressing malignancies including chimeric antigen receptors (CARs) and T cells containing CARs (CAR T-cells). The invention also provides methods and compositions comprising CAR T-cells co-expressing other anti-tumoral agents including cytokines and antibodies.

Abstract: The present invention provides compositions and methods for treating KMA-expressing malignancies including chimeric antigen receptors (CARs) and T cells containing CARs (CAR T-cells). The invention also provides methods and compositions comprising CAR T-cells co-expressing other anti-tumoral agents including cytokines and antibodies.

Abstract: Disclosed herein are extracellular vesicles such as exosomes that selectively target cells such as skeletal muscle cells. Such vesicles include skeletal muscle targeting moieties and can be used to selectively deliver a payload to skeletal muscle cells or tissue.

Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.

Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.

Abstract: A system and method for facilitating purchase of goods and services by pre-payment via a universal gift or other pre-paid card with incentives. The universal gift or other pre-paid card provides incentives to vendors and consumers that use it. It permits flexible purchase of goods and services by consumers. The consumers are recipients of the universal gift card from others or purchasers of the universal gift card who decide to use the card themselves. The universal gift card is usable at any one of a plurality of merchants who are designated and authorized by the system. The universal gift card permits purchase up to a specified amount, which must be paid by a consumer prior to its use. The specified amount is either maintained on the universal gift card itself or is maintained on a database associated with the system, which maintains associated accounts and controls its use. The universal gift card preferably has few restrictions (e.g. expiration date), if any, to facilitate ease of use by consumers.

Abstract: The present invention provides compositions and methods for treating KMA-expressing malignancies including chimeric antigen receptors (CARs) and T cells containing CARs (CAR T-cells). The invention also provides methods and compositions comprising CAR T-cells co-expressing other anti-tumoral agents including cytokines and antibodies.

Abstract: A method and system is described for rapidly classifying a sample of a biological fluid, comprising obtaining a spectrum of the biological fluid in response to excitation of the sample in a specified frequency range, and applying a multivariate classifier to one or more spectral regions of the spectrum to classify the biological sample into one class in a set of classes, the classes comprising at least two disease states having similar clinical symptoms. Methods and systems for developing the classifiers are also described. In one example the classification uses a vibrational spectrometer (5) to provide spectra from serum. The multivariate classifier may run on processor (9) to distinguish between disease states having similar clinical symptoms, such as malaria and cerebral malaria.

Abstract: A system and method for facilitating purchase of goods and services by pre-payment via a universal gift or other pre-paid card with incentives. The universal gift or other pre-paid card provides incentives to vendors and consumers that use it. It permits flexible purchase of goods and services by consumers. The consumers are recipients of the universal gift card from others or purchasers of the universal gift card who decide to use the card themselves. The universal gift card is usable at any one of a plurality of merchants who are designated and authorized by the system. The universal gift card permits purchase up to a specified amount, which must be paid by a consumer prior to its use. The specified amount is either maintained on the universal gift card itself or is maintained on a database associated with the system, which maintains associated accounts and controls its use. The universal gift card preferably has few restrictions (e.g. expiration date), if any, to facilitate ease of use by consumers.

Abstract: A method and system for notifying a user to review a document stored on a computer. The method scans the document to identify and locate a citation in the document, where the citation is a link to a target document. The method stores the citation in a citations database. The method periodically compares the citations database to a changed documents database. When the comparison determines that the target document is a changed document, the method stores an entry in a hits database, where the entry identifies the document, the citation, and the target document. The method sends an alert message to the user to request that the user review the entry in the hits database.

Abstract: A method and system for managing delivery of a web resource to a user on a web server. The method determines the identity of the user on the web server and retrieves the web resource from the web server. The method scans the web resource to identify links, such as hypertext links, in the web resource that refer to a target web resource. For each link, the method determines whether access is allowed or denied by the user to the target web resource. The method creates a copy of the web resource and deactivates each link in the copy of the web resource if access is denied by the user to the target web resource referred to by the link. The method then delivers the copy of the web resource to the user on the web server.

Abstract: A method and computer device for connecting structured documents stored on a source computer to structured documents stored on a target computer. The method identifies links in the structured documents on the source computer and linkable elements in the structured documents on the target computer. Each link on the source computer points to a linkable element on the target computer. The method transmits the links from the source computer to the target computer and associates each link with one of the linkable elements. The method determines changes to the links in the structured documents on the source computer based on changes to the structured documents on the target computer. The method transmits the link changes to the source computer which updates the links based on the link changes.

Abstract: A framework for customer relationship management includes a first layer to identify platforms for customer interactions and a second layer to identify capabilities of customer interactions. The framework includes a third layer to demonstrate how knowledge about customer preferences and behavior can be brought to bear on customer interactions. The framework has a fourth layer to identify applications of analysis and modeling to customer information. The framework also can include backplanes identifying common services that can be defined and tailored to support capabilities described in the first, second, third and fourth layers.

Abstract: The present invention relates to a novel removable, yet secure, gutter and fastener system. More particularly, the invention relates to elongated roof gutter sections which include a bottom member and a front wall and a rear wall attached lengthwise along the member's opposite edges thereby forming a channel. The gutter sections further include an overhanging lip consisting of the bottom member and protruding away from the channel at either end of the channel. The elongated roof gutter sections are removably mounted using a hook and slot, or an interlocking flange system to an elongated fastener member which, in turn, is mounted along the roof line of a building.