Abstract: An apparatus for calibrating output from an image classifier. The apparatus has an image classifier trained to compute, from an image, confidence values for each of a plurality of skin conditions potentially depicted in the image. The apparatus has a processor to compute a probability score for at least one skin condition by adjusting an associated confidence value using information from an incidence corrected data set which is a plurality of images resampled according to data about an incidence of the skin condition in a population from which the image was captured.

Abstract: A wound dressing material may include a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may include collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may, for example, be an aniline or acridine dye. Also disclosed are methods of making such materials, and wound dressings that include such materials.

Abstract: A wound dressing material may include a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may include collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may, for example, be an aniline or acridine dye. Also disclosed are methods of making such materials, and wound dressings that include such materials.

Abstract: Methods for determining a genetic identity of a cell, tissue, organ, or organism, based on type, position, and size of every occurrence of at least one repetitive element in the genome of the cell, tissue, organ, or organism. The methods can include using a computer to generate a graphical representation of the genetic identity of the cell, tissue, organ, or organism, and comparing genetic identity at different times/spaces. Also described herein is a computer implemented Universal Genome Information System, which serves as a genome-RE/TRE information management and analysis platform.

Abstract: The use of a nicotinamide derivative in the treatment acute coronary syndrome (ACS) and pharmaceutical compositions used in such treatment.

Abstract: A wound dressing material comprising a solid bioabsorbable substrate dyed with an antioxidant dyestuff. The substrate may comprise collagen, chitosan or oxidized regenerated cellulose, and the dyestuff may for example be an aniline or acridine dye. The material preferably also comprises a silver salt, whereby the dyestuff stabilizes the silver salt. Also provided are methods of making such materials, and wound dressings comprising such materials.

Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye. Also provided are methods of making such materials, and wound dressings comprising such materials.

Abstract: The present invention relates to the use of a nicotinamide derivative in the treatment acute coronary syndrome (ACS) and pharmaceutical compositions used in such treatment.

Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye.

Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye.

Abstract: The invention provides a wound dressing material comprising a complex of an anionic polysaccharide with silver, wherein the material comprises from about 0.1 wt. % to about 3 wt. % of silver. Also provided are wound dressings comprising such materials, and the use of such materials in medicine.

Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye. Also provided are methods of making such materials, and wound dressings comprising such materials.

Abstract: A device for detecting a mammalian host-derived enzyme in a sample of a wound fluid, said device comprising: a housing having an inlet for the sample and side walls defining a fluid flow path extending from said inlet an indicator moiety that is bound to a solid substrate by means of a peptide linker moiety that is cleavable by said host-derived enzyme, said solid substrate being located in a reaction zone of said fluid flow path; and a detector moiety located in a detection zone downstream from the reaction zone in said fluid flow path, wherein the detector moiety interacts with an indicator moiety that has been cleaved from said solid substrate to produce a detectable change in said detection zone. Suitably, the device further comprises a control moiety located in a control zone in said device, wherein the control moiety can interact with a component of the wound fluid sample to improve the accuracy of the device.

Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag30 , and the dyestuff may for example be an aniline or acridine dye. Also provided are methods of making such materials, and wound dressings comprising such materials.

Abstract: The invention provides a wound dressing material comprising a complex of an anionic polysaccharide with silver, wherein the material comprises from about 0.1 wt. % to about 3 wt. % of silver. Also provided are wound dressings comprising such materials, and the use of such materials in medicine.

Abstract: Gene therapy by using specific expression vectors within the epidermis or epidermal cells. These vectors incorporate regulatory sequences of tissue and differentiation-specific genes.

Abstract: A keratin K1 vector for expression of a nucleic acid sequence in an epidermal cell. The vector includes a 5' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a keratin K1 3' flanking region which regulates expression of a nucleic acid sequence, predominantly in the epidermis, and a linker which connects the 5' flanking region to a nucleic acid. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. That is, the linker is not the normal gene associated with the 5' and 3' regions.

Abstract: Gene therapy by using specific expression vectors within the epidermis or epidermal cells. These vectors incorporate regulatory sequences of tissue and differentiation-specific genes.