Abstract: Various shaped abrasive particles are disclosed. Each shaped abrasive particle includes a body having at least one major surface and a side surface extending from the major surface.

Abstract: A steerable delivery system is provided for delivering a replacement heart valve to a native heart valve location. The steerable delivery system includes an outer sheath assembly having a capsule along a distal end portion for retaining the replacement heart valve in a compressed configuration. The capsule is constructed to provide both compression resistance and flexibility. The capsule may be formed with an outer polymer layer, a metal middle layer located on a radially inner surface of the outer polymer layer, and an inner liner located on a radially inner surface of the metal middle layer. A fluoroelastomer layer is provided for bonding the inner liner to the metal middle layer. The metal middle layer is preferably a metal hypotube.

Abstract: A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the electrode under conditions in which the first and second target molecules are deposited on the electrode, wherein the first target molecule comprises a first label and the second target molecule comprises a second label; (c) contacting to the electrode a first transition metal complex that oxidizes the first preselected label in a first oxidation-reduction reaction and a second transition metal complex that oxidizes the first and second labels in a second oxidation-reduction reaction, with the first and second oxidation-reduction reactions producing different detectable signals; (d) detecting the presence of the first target molecule by detecting the first oxidation-reduction reaction; and (e) detecting the presence of the second target molecule by

Abstract: A method for manufacturing a molded structure in a press that includes a first mold and a second mold is provided. The second mold has a plurality of pressure actuators, with each pressure actuator capable of independent operation. The method includes the steps of positioning a preform having a thickness in the first mold, placing a quantity of resin adjacent the preform so as to create a resin reservoir, and then selectively actuating one or more of the pressure actuators apply pressure to the resin reservoir to force at least a portion of the resin reservoir to infuse through the thickness of the preform. The method may also include curing the resin-infused preform, and then removing the cured resin-infused preform from the first mold.

Abstract: A method of detecting binding interactions and target molecules, such as proteins, protein fragments, recombinant proteins, recombinant protein fragments, extracellular matrix proteins, ligands, carbohydrates, steroids, hormones, drugs, drug candidates, immunoglobulins and receptors of eukaryotic, prokaryotic or viral origin, by mediated electrochemistry using labels that react with transition metal mediator complexes in a detectable catalytic redox reaction. These labels are attached directly to binders, target molecules, surrogate target molecules, or to affinity ligands capable of binding to the target or to surrogate target molecules capable of competing with the target for binding to another binder. The labels can be naturally present (endogenous) in the binder, target or affinity ligand, or constructed by the covalent attachment of the label to the binder, target, affinity ligand or surrogate target (exogenous).

Abstract: A method for manufacturing a near net-shape mold from a weldable material, including creating a computer model of a mold portion (30,32), analytically sectioning the computer model of the mold portion into a plurality of mold zones (22), generating mold zone cutting paths for a cutting machine to follow, cutting the weldable material into plurality of mold zones, generating surface profile cutting paths for a cutting machine to follow, machining surface profiles into the mold zones, assembling the mold zones by placing the mold zones side-by-side, generating welding paths for an electron beam welding a machine to follow, and welding the mold zones together.

Abstract: A method for manufacturing a molded structure in a press that includes a first mold and a second mold is provided. The second mold has a plurality of pressure actuators, with each pressure actuator capable of independent operation. The method includes the steps of positioning a preform having a thickness in the first mold, placing a quantity of resin adjacent the preform so as to create a resin reservoir, and then selectively actuating one or more of the pressure actuators apply pressure to the resin reservoir to force at least a portion of the resin reservoir to infuse through the thickness of the preform. The method may also include curing the resin-infused preform, and then removing the cured resin-infused preform from the first mold.

Abstract: A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the electrode under conditions in which the first and second target molecules are deposited on the electrode, wherein the first target molecule comprises a first label and the second target molecule comprises a second label; (c) contacting to the electrode a first transition metal complex that oxidizes the first preselected label in a first oxidation-reduction reaction and a second transition metal complex that oxidizes the first and second labels in a second oxidation-reduction reaction, with the first and second oxidation-reduction reactions producing different detectable signals; (d) detecting the presence of the first target molecule by detecting the first oxidation-reduction reaction; and(e) detecting the presence of the second target molecule by d

Abstract: A method for manufacturing a molded structure in a press that includes the steps of positioning a preform (24) having a thickness in the lower mold (20), placing a quantity of resin adjacent the preform (24) so as to create a resin reservoir, and then selectively actuating one or more of the pressure actuators (28) to apply pressure to the resin reservoir to force at least a portion of the resin reservoir to infuse through the thickness of the preform (24). After the step of positioning, a top cover (32) may be placed upon the preform (24). The step of selectively actuating one or more of the pressure actuators (28) attached to an upper platen (60), may include a computer for controlling the pressure actuators (28).

Abstract: A method of detecting binding interactions and target molecules, such as proteins, protein fragments, recombinant proteins, recombinant protein fragments, extracellular matrix proteins, ligands, carbohydrates, steroids, hormones, drugs, drug candidates, immunoglobulins and receptors of eukaryotic, prokaryotic or viral origin, by mediated electrochemistry using labels that react with transition metal mediator complexes in a detectable catalytic redox reaction. These labels are attached directly to binders, target molecules, surrogate target molecules, or to affinity ligands capable of binding to the target or to surrogate target molecules capable of competing with the target for binding to another binder. The labels can be naturally present (endogenous) in the binder, target or affinity ligand, or constructed by the covalent attachment of the label to the binder, target, affinity ligand or surrogate target (exogenous).

Abstract: A method of detecting binding interactions and target molecules, such as proteins, protein fragments, recombinant proteins, recombinant protein fragments, extracellular matrix proteins, ligands, carbohydrates, steroids, hormones, drugs, drug candidates, immunoglobulins and receptors of eukaryotic, prokaryotic or viral origin, by mediated electrochemistry using labels that react with transition metal mediator complexes in a detectable catalytic redox reaction. These labels are attached directly to binders, target molecules, surrogate target molecules, or to affinity ligands capable of binding to the target or to surrogate target molecules capable of competing with the target for binding to another binder. The labels can be naturally present (endogenous) in the binder, target or affinity ligand, or constructed by the covalent attachment of the label to the binder, target, affinity ligand or surrogate target (exogenous).

Abstract: An athletic garment designed to protect the wearer from injury during athletic activity such as in-line roller skating, skiing, volleyball, mountain biking, basketball, hockey, field hockey, ice skating or gymnastics. The invention uses strategically placed and rib-shaped gel, air or elastic foam padding to protect the wearer from the impact and abrasion of a fall caused by such activity.