Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.

Abstract: Methods, computer-readable media, software, and apparatuses are provided to assist a user and vendor in completing an online trusted transaction. Trusted vendor websites are verified and user identities are confirmed through a cyber-security safe logon credentialing system. The vendor can be confident that the user identity has been verified to be who they say they are and the user can be confident that they are using a trusted verified vendor website.

Abstract: Aspects of the disclosure relate to a system and method for securely authenticating a device via token(s) and/or verification computing device(s). A verification computing device may generate a pseudorandom number or sequence. Based on the pseudorandom number or sequence, the verification computing device may select a first plurality of parameters associated with a user of a device to be authenticated. The verification computing device may transmit, to the device, the pseudorandom number or sequence, and the device may select a second plurality of parameters. The device may generate a token based on the second plurality of parameters. The device may send the token to another device, and the other device may send the token to the verification computing device. The verification computing device may authenticate the device based on the token.

Abstract: A classification method comprises positioning an object and a radar unit in proximity to each other; receiving by the radar unit radar signals reflected from the object; and classifying the object, wherein the classifying is based on the radar signals and/or at least one feature extracted from the radar signals, and the classifying of the object comprises determining classification data for the object.

Abstract: An endpoint in an enterprise network is monitored, and when a potential trigger for a distributed denial of service (DDoS) attack is followed by an increase in network traffic from the endpoint to a high reputation network address, the endpoint is treated as a DDoS service bot and isolated from the network until remediation can be performed.

Abstract: Aspects of the disclosure relate to a system and method for securely authenticating a device via token(s) and/or verification computing device(s). A verification computing device may generate a pseudorandom number or sequence. Based on the pseudorandom number or sequence, the verification computing device may select a first plurality of parameters associated with a user of a device to be authenticated. The verification computing device may transmit, to the device, the pseudorandom number or sequence, and the device may select a second plurality of parameters. The device may generate a token based on the second plurality of parameters. The device may send the token to another device, and the other device may send the token to the verification computing device. The verification computing device may authenticate the device based on the token.

Abstract: Methods and systems are disclosed that enable the leveraging of financial instrument research at an individual financial instrument level but across multiple classifications of financial instruments to efficiently build an investment portfolio for an investor based on a desired portfolio objective through a plurality of graphical user interfaces (GUIs).

Abstract: A device for detecting properties of soft tissue. The device comprises a probe coupled to drive means to urge the probe against the soft tissue, a detector for determining applied stress to the soft tissue, and an ultrasonic transmitter configured to, in use, transmit ultrasound waves through at least a portion of the probe and through the soft tissue. A system including the device is also provided along with a corresponding method.

Abstract: An endpoint coupled in a communicating relationship with an enterprise network may include a data recorder configured to store an event stream of data indicating events on the endpoint including types of changes to computing objects, a filter configured to locally process the event stream into a filtered event stream including a subset of types of changes to the computing objects, and a local security agent. The local security agent may be configured to transmit the filtered event stream to a threat management facility, respond to a filter adjustment from the threat management facility by adjusting the filter to modify the subset of types of changes included in the filtered event stream, and respond to a query from the threat management facility by retrieving data stored in the data recorder over a time window before the query and excluded from the filtered event stream.

Abstract: In a threat management platform, a number of endpoints log events in an event data recorder. A local agent filters this data and feeds a filtered data stream to a central threat management facility. The central threat management facility can locally or globally tune filtering by local agents based on the current data stream, and can query local event data recorders for additional information where necessary or helpful in threat detection or forensic analysis. The central threat management facility also stores and deploys a number of security tools such as a web-based user interface supported by machine learning models to identify potential threats requiring human intervention and other models to provide human-readable context for evaluating potential threats.

Abstract: The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Selective transport of the microbial metabolite lithocholic acid (LCA) from the gut to the liver after bariatric surgery activates hepatic vitamin D receptor (VDR), thereby inducing expression of bile acid sulfotransferase SULT2A, which produces the antidiabetic molecule CA7S. Provided herein is a method for treating diabetes, obesity, or an inflammatory disease in a subject, the method comprises administering to a subject in need thereof a compound of Formula I-XV or Formula F-XV? or an agent that increases levels or activity or cholic acid 7-sulfate or upstream targets in a subject.

Abstract: A method and assembly for protecting a device connected to a wiring harness is disclosed. The assembly includes a protective tubular shield and a positioning device, with the protective tubular shield having a bore for receiving the device at least partially therein. An elongated wiring harness extends from the device being protected and through the bore of the protective tubular shield. The positioning device is formed having a band and at least one flexible, resilient finger extending radially inwardly from the band. At least one of the fingers forcibly engages the wiring harness to releasably maintain the positioning device and the protective tubular shield in a protection position along the wiring harness at least partially surrounding the device being protected.

Abstract: A stopper for securing an end of a lace in an article having at least one eyelet, the stopper comprising a body member having first and second sides and first, second, and third through openings. The second through opening is located a spaced distance from the first opening. The third through opening being located on a side of the first through opening opposite the second through opening and being sized and dimensioned to spread at portion of the lace in the third through opening into a flattened form. The lace engaging edge on the body member located on a side of the second through opening generally opposite the first through opening for passage of the lace thereover from the second through opening to the third through opening.

Abstract: A multi-endpoint event graph causally relates a sequence of events among a number of computing objects at a number of logical locations including multiple endpoints in an enterprise network. The multi-endpoint event graph is used to detect malware based on malicious software moving through the enterprise network.

Abstract: A multi-endpoint event graph is used to detect malware based on malicious software moving through a network.

Abstract: A method and assembly for protecting a device connected to a wiring harness is disclosed. The assembly includes a protective tubular shield and a positioning device, with the protective tubular shield having a bore for receiving the device at least partially therein. An elongated wiring harness extends from the device being protected and through the bore of the protective tubular shield. The positioning device is formed having a band and at least one flexible, resilient finger extending radially inwardly from the band. At least one of the fingers forcibly engages the wiring harness to releasably maintain the positioning device and the protective tubular shield in a protection position along the wiring harness at least partially surrounding the device being protected.

Abstract: The present invention provides methods and compositions for treatment of prion disease.

Abstract: A vehicle mounted monitoring system for removable propane tanks includes a propane tank holding system, at least one tank measuring sensor, a hard-wired vehicular power connection, a main control module, and a vehicular display module. The propane tank holding system includes at least one resting bracket so that a propane tank can be placed and secured. The tank measuring sensor is operatively coupled to the resting bracket to measure the remaining amount of liquid in the propane tank. The hard-wired vehicular power connection is electrically connected to the tank measuring sensor for continuous operation. The tank measuring sensor is electronically connected to the vehicular display module through the main control module so that the user can be informed.

Abstract: An ultrasonic transducer is described, including a piezoelectric element, a fluid medium contact layer, a matching layer between the piezoelectric element and the fluid medium contact layer, and a backing layer. Ultrasound sensor devices utilising the ultrasonic transducer are also described, for use in systems for analysing a fluid such as milk.

Abstract: A stopper for securing an end of a lace in an article having at least one eyelet, such as a shoe, without having to form an exposed knot. A thin, rigid body includes a series of openings arranged in a row, including a first, middle opening through which the lace is routed from the eyelet, a second opening proximate one end through which the lace is routed from the middle opening, and a third opening proximate an opposite through which the lace is routed from the second opening via the first end of the body, the third opening having a slot-shaped configuration. When tension is applied to the lace, as by a foot being inserted into a shoe, a locking engagement is formed between the lace and stopper and the stopper reacts against the eyelet. The stopper may be hidden from view behind the eyelet stay of a shoe.