Abstract: In one aspect, embodiments disclosed herein are directed to engineered CRISPRCas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type II effector protein. In certain other example embodiments, the Type V effector protein is Cas9 or an orthologs or engineered variant thereof. Example Cas9 proteins suitable for use in the embodiments disclosed herein are discussed in further detail below.

Abstract: Embodiments of a patient transport platform employing one or more adjustable columns interposed between a base having caster wheels with one or more intermediate large wheels, the adjustable columns accommodating deployment and retraction of the large wheels and elevation and positioning of an articulating patient stretcher chair. In various embodiments, the adjustable columns are in parallel or series connection, or combinations thereof. An articulating base frame assembly with a dampened interconnection between fore and aft sections, having three pairs of wheels for selective implementation in use is also presented.

Abstract: Embodiments of a patient transport platform employing one or more adjustable columns interposed between a base having caster wheels with one or more intermediate large wheels, the adjustable columns accommodating deployment and retraction of the large wheels and elevation and positioning of an articulating patient stretcher chair. In various embodiments, the adjustable columns are in parallel or series connection, or combinations thereof. An articulating base frame assembly with a dampened interconnection between fore and aft sections, having three pairs of wheels for selective implementation in use is also presented.

Abstract: In accordance with one example embodiment of a Digital Advertising Trade Amplifier system, the system comprises a processing engine and content server for dynamically generating digital ad content relating to trade events or trade promotions from ad copy and images for a product and/or a service sold through a retail business, a database for storing the ad copy, the images, and the trade event digital ad content, and an administrative tool for inputting the ad copy and images into the database and configuring programs and for facilitating functionality between the database and the processing engine and content server in order to create, modify, and disseminate the trade event digital ad content. The trade event digital ad content is used to create a trade-specific digital ad based on at least one of an event location, an event date, and contextual placement of the trade event digital ad content.

Abstract: Shade structures include awning fabrics carried by awning rolls from which they may be extended to provide shade to areas, and into which they may be retracted when shade is not needed. Closed systems are disclosed in which one or more awning fabrics can be extended through a single drive system. In particular embodiments, the shade structures cover large surface areas and include solar cells for the generation of photovoltaic power.

Abstract: A hydraulic dry power take-off clutch is adapted to be retrofit for prior manually actuated dry over-center power take-offs in compliance with certain SAE specifications. Both the resultant clutch and a retrofit kit for effecting the same are presented. According to the invention, an input hub is securedly received upon a shaft with an end plate secured to the input hub. A drive flange is adapted for securement to a flywheel or power source. A hydraulically actuated clutch disk assembly is received by the input hub and is in interconnection with the dry flange. Finally, a rotary union is received upon an end of the input hub opposite that of the clutch disk assembly, the rotary union providing a conduit for passing pressurized hydraulic fluid to the clutch disk assembly. The entire structure is adapted to be received within the same bell housing, and to employ the same drive ring as the prior art dry over-center power take-off units.

Abstract: The invention teaches an apparatus and method for using an apparatus that provides a golf bag at an angle from an upright position on a motorized golf. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).