Abstract: Described is an autoinjector comprising of a case, a motor adapted to rotate a drive gear, and a curvi-linear plunger adapted to mate with the drive gear. The plunger includes a distal end with a resilient flange, which in a non-deflected state, abuts a proximal collar of a syringe, and, in a deflected state, advances through the proximal collar and engages a stopper in the syringe.

Abstract: A method, device and system for organizing media content on a computer-based system to form a playlist, wherein the device has access to a database with a plurality of music tracks and associated feature vectors including feature values representing different semantic characteristics of a music track, as well as metadata including at least one type of metadata record representing associated information about the respective music track. The playlist is determined based on a query from the client device that includes an input vector, and at least one input metadata record, using an additional similarity matrix representing a measure of similarity between different metadata records of the same type.

Abstract: An autoinjector includes a case configured to receive a syringe, a slidable member that is movable axially within the case to cause at least a portion of the syringe to move axially when the syringe is disposed within the case for dispensing a medicament through a needle of the syringe, a locking member configured to prevent actuation of the slidable member when the autoinjector is in a pre-dispense configuration, a sleeve coupled to a distal end of the case and surrounding at least a portion of a needle of the syringe when the syringe is disposed within the case, an elongate member extending proximally from the sleeve and configured to deflect the locking member to allow actuation of the plunger, and two drive springs coupled to the slidable member and configured to apply a biasing force that acts on the slidable member to move the slidable member distally.

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, CY, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.

Abstract: The ends of the adjustable shoring beam can be adjusted to different heights along one or more securement tracks on a vertical post. The adjustable shoring beam engages the securement tracks on the vertical posts and each end is independently adjustable in one degree of freedom. Modular deck tracks on the vertical posts, adjacent to the securement tracks, allow for the engagement of a modular deck with a vertical post. The modular deck and securement beam are able to be moved independently past each other on the vertical posts by a user or an autonomous machine.

Abstract: Ambulatory medicament devices that provide therapy to a subject, such as blood glucose control, are disclosed. Disclosed systems and methods can implement one or more features that improve the user experience, by modifying delivery of therapy to a subject after determining that a possible occlusion exists in a medicament delivery system, monitoring the status of an ambulatory medical device and the health condition of a subject that receives therapy from the ambulatory medical device and annunciating alarm condition when necessary, selectively muting alarm annunciations while a Do Not Disturb mode is activated, implementing various power saving modes to save power, controlling operation of the device and medicament delivery based on the user gesture controls, and controlling medicament delivery based on a condition of the ambulatory medicament device.

Abstract: Microvalve assemblies are disclosed that in some examples include a body including first and second ports and a body plate. The microvalve assemblies further include an actuator assembly including one or more exterior plates coupled to a stack. One of the one or more exterior plates contacts the body plate to form a seat and thereby restrict fluid flow from the first port to the second port, when the stack is not energized. Additionally, the actuator assembly is configured to, when the stack is energized, periodically generate a gap between the one of the one or more exterior plates and the body plate via near-field-acoustic-levitation (NFAL) to allow fluid flow through the first and second ports. Advantageously, the microvalves of this technology are relatively small and consume minimal power, thereby overcoming size and power limitations of existing valves, including pneumatic valve technologies.

Abstract: A method for producing a metal powder includes maintaining molten reducing metal in a sealed reaction vessel that is free of added oxygen and water, establishing a vortex in the molten reducing metal, introducing a metal halide into the vortex so that the molten reducing metal is in a stoichiometric excess to the metal halide, thereby producing metal particles and salt, removing unreacted reducing metal, removing the salt, and recovering the metal powder. The molten reducing metal can be a Group I metal, a Group II metal, or aluminum.

Abstract: An actuator assembly includes one or more conductive coils each positioned in a movable supporting frame configured to be coupled to a load. A pair of permanent magnets are located on each side of each of the coils to provide opposite polarity magnetic fields to each of the coils. A drive circuit is coupled to the each of coils and configured to supply a drive current to each of the conductive coils. A controller is coupled to each of the coils through the drive circuit and is configured to independently control the drive current supplied to each of the coils to provide movement of the supporting frame to provide a force to the load, based on the opposite polarity fields and the drive current, wherein the movement of the supporting frame is in proportion to an amplitude and polarity of the drive current.

Abstract: A gas sensor has a light detector, a gas-tight support structure enclosing the light detector, a window positioned in said support structure, and a light source mounted to the support structure. A sample area is positioned in the support structure to receive a gas to be tested. The light source is aligned with the window, sample area, and the light detector to pass light from the light source through the gas in the sample area to the light detector. The sensor can be provided in a breadth sampling apparatus that has deflects gas to a bypass route so that only a portion of gas reaches the sensor.

Abstract: A gas sensor has a light detector, a gas-tight support structure enclosing the light detector, a window positioned in said support structure, and a light source mounted to the support structure. A sample area is positioned in the support structure to receive a gas to be tested. The light source is aligned with the window, sample area, and the light detector to pass light from the light source through the gas in the sample area to the light detector. The sensor can be provided in a breadth sampling apparatus that has deflects gas to a bypass route so that only a portion of gas reaches the sensor.

Abstract: Microvalve assemblies are disclosed that in some examples include a body including first and second ports and a body plate. The microvalve assemblies further include an actuator assembly including one or more exterior plates coupled to a stack. One of the one or more exterior plates contacts the body plate to form a seat and thereby restrict fluid flow from the first port to the second port, when the stack is not energized. Additionally, the actuator assembly is configured to, when the stack is energized, periodically generate a gap between the one of the one or more exterior plates and the body plate via near-field-acoustic-levitation (NFAL) to allow fluid flow through the first and second ports. Advantageously, the microvalves of this technology are relatively small and consume minimal power, thereby overcoming size and power limitations of existing valves, including pneumatic valve technologies.

Abstract: A gas sensor has a light detector, a gas-tight support structure enclosing the light detector, a window positioned in said support structure, and a light source mounted to the support structure. A sample area is positioned in the support structure to receive a gas to be tested. The light source is aligned with the window, sample area, and the light detector to pass light from the light source through the gas in the sample area to the light detector. The sensor can be provided in a breadth sampling apparatus that has deflects gas to a bypass route so that only a portion of gas reaches the sensor.

Abstract: The disclosed principles provide for an RF front-end design capable of up-converting, down-converting, and conditioning broadband signals for wireless transmission with an instantaneous bandwidth of up to 3.5 GHz within the frequency range of 2-12 GHz. In addition, embodiments of the disclosed principles provide flexibility that enables RF front-ends designed as disclosed herein to be applied to many different applications including covert communications, drone communications, high data rate communications, signals intelligence, direction finding, multi-function apertures, radars and emulators, and electronic warfare. Embodiments and their related advantages and improvements of RF front-ends designed in accordance with the disclosed principles are discussed herein.

Abstract: Isolation plugs may be installed in a wellbore flow control device to temporarily close a flow path therethrough. The isolation plugs may be installed in threaded openings often provided to for access to nozzles or other flow restrictors in the flow control devices. The isolation plugs may initially be locked in a closed configuration while being run in hole and may be unlocked in response to the application of a predetermined activation pressure. Once unlocked, the isolation plug may not immediately move to an open configuration but may continue holding pressure to permit circulation and washdown operations to be conducted. The activation pressure may be reduced to a second predetermined threshold to lock the isolation plug in the open configuration wherein flow is permitted through the flow control device.

Abstract: The disclosed principles provide for an RF front-end design capable of up-converting, down-converting, and conditioning broadband signals for wireless transmission with an instantaneous bandwidth of up to 3.5 GHz within the frequency range of 2-12 GHz. In addition, embodiments of the disclosed principles provide flexibility that enables RF front-ends designed as disclosed herein to be applied to many different applications including covert communications, drone communications, high data rate communications, signals intelligence, direction finding, multi-function apertures, radars and emulators, and electronic warfare. Embodiments and their related advantages and improvements of RF front-ends designed in accordance with the disclosed principles are discussed herein.

Abstract: A method for playing out a media program including a primary programming. The method includes storing the primary programming; forming first and second sets of content for play-out during a break in the primary programming, where the second set's duration differs by less than a predetermined amount from the duration of the first set of content transmitting, by a first mechanism, a base program including the primary programming and subsequently, during the break, the first set of content, and after the break, the primary programming; and transmitting, by a second mechanism, the primary programming at a first time offset to the transmitting by the first mechanism before the break and subsequently, during the break, the second set of content and after the break, the primary programming at a second time offset to the transmitting by the first mechanism, after the break, the first and second time offsets being different.

Abstract: A display system comprising a steerable display having a monocular field of view of at least 1 degree, positioned within a scannable field of view of at least 20 degrees, the steerable display positioned for a user. In one embodiment, the steerable display is positioned for the user's fovea.