Abstract: An apparatus comprises a thermally conductive receptacle holder including a plurality of receptacle wells configured to receive receptacles, a plurality of optical fibers having first and second ends, wherein each first end is in optical communication with one of the receptacle wells and each second end is in optical communication with an excitation signal source and/or an emission signal detector, one or more thermal elements positioned proximal to the receptacle holder for altering the temperature of the receptacle holder, a heat sink in thermal communication with the receptacle holder, and one or more thermal devices disposed within the heat sink for pre-heating the heat sink.

Abstract: An apparatus for incubating a plurality of receptacles includes one or more thermally-conductive receptacle holders, each comprising a plurality of receptacle wells. A thermally-conductive support is associated with each of the receptacle holders, and a thermal element is positioned between the associated support and the receptacle holder. A heat sink is in thermal communication with the support and comprises a plurality of spaced-apart fins. An optical fiber associated with each receptacle well has a first end positioned adjacent to or within a through-hole formed in the receptacle well and extends through through-holes formed in the support and the heat sink aligned with the through-hole of the receptacle well. Each of the optical fibers is positioned between two adjacent fins of the plurality of fins.

Abstract: The present disclosure relates to and envisages a jetstream power generating system. Producing electric power from jetstream force presents specific, daunting, physics-based challenges, because jetstream forces are 30 to 50 times stronger than wind on the ground. The system is configured to harness the energy of these jetstream forces in farms as power generating infrastructure. The system comprises an airborne element configured to be subjected to lift forces while flying in a jetstream, a capstan drum, a tether coupled between the airborne element and the capstan drum, an arcuate guide track, a kite tracker displaceably mounted on the guide track, a conversion unit coupled to the capstan drum, a plurality of accumulators configured to fluidly communicate with the conversion unit, and a generator.

Abstract: An acoustic core may include an array of resonant cells configured as a plurality of resonant cell groups. The resonant cell groups may include a plurality of resonant cells configured as a partitioned resonant cell that include a converging resonant cell and a diverging resonant cell. The converging resonant cell and the diverging resonant cell may be defined by a plurality of cell walls integrally formed with one another and a partition integrally formed with the plurality of cell walls. The partition may at least partially delimit the converging resonant cell from the diverging resonant cell. The converging resonant cell may define an upper resonant space delimited by the partition and a top face of the array of resonant cells. The diverging resonant cell may define a lower resonant space delimited by the partition and a bottom face of the array of resonant cells.

Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A system for healthcare resource scheduling is configured to calculate differential demand for a type of healthcare resource; based on the differential demand for the type of healthcare resource, determine, via an optimization engine, a suggested resource assignment; cause an operator device to display a user interface that displays a visual representation of the differential demand for the type of healthcare resource and a visual representation of the suggested resource assignment, wherein the visual representation of the suggested resource assignment is selectable by an operator of the operator device; receive, from the operator device, an operator selection comprising a selection of the suggested resource assignment in the user interface; and transmit an assignment notification to a computing device associated with a particular available resource of the type of healthcare resource.

Abstract: A system for healthcare resource scheduling is configured to calculate differential demand for a type of healthcare resource; based on the differential demand for the type of healthcare resource, determine, via an optimization engine, a suggested resource assignment; cause an operator device to display a user interface that displays a visual representation of the differential demand for the type of healthcare resource and a visual representation of the suggested resource assignment, wherein the visual representation of the suggested resource assignment is selectable by an operator of the operator device; receive, from the operator device, an operator selection comprising a selection of the suggested resource assignment in the user interface; and transmit an assignment notification to a computing device associated with a particular available resource of the type of healthcare resource.

Abstract: Embodiments herein relate to a local assistant system responding to voice input using an ear-wearable device. The system detects a wake-up signal and receives a first voice input communicating a first query content. The system includes speech recognition circuitry to determine the first query content, speech generation circuitry, and an input database of locally-handled user inputs. If the first audio input matches one of the locally-handled user inputs, then the system takes a local responsive action. If the first audio input does not match one of the locally-handled user inputs, then the system transmits at least a portion of the first query content over a wireless network to a network resource.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A method includes receiving a spoken utterance that includes a plurality of words, and generating, using a neural network-based utterance classifier comprising a stack of multiple Long-Short Term Memory (LSTM) layers, a respective textual representation for each word of the of the plurality of words of the spoken utterance. The neural network-based utterance classifier trained on negative training examples of spoken utterances not directed toward an automated assistant server. The method further including determining, using the respective textual representation generated for each word of the plurality of words of the spoken utterance, that the spoken utterance is one of directed toward the automated assistant server or not directed toward the automated assistant server, and when the spoken utterance is directed toward the automated assistant server, generating instructions that cause the automated assistant server to generate a response to the spoken utterance.

Abstract: A smoking article may include a cigarette incorporated within an electrically powered aerosol generating device that acts as a holder for that cigarette. The smoking article possesses at least one form of tobacco. The smoking article also possesses a mouth-end piece that is used by the smoker to inhale components of tobacco that are generated by the action of heat upon components of the cigarette. A representative smoking article possesses an outer housing incorporating a source of electrical power (e.g., a battery), a sensing mechanism for powering the device at least during periods of draw, and a heating device (e.g., at least one electrical resistance heating element) for forming a thermally generated aerosol that incorporates components of tobacco. During use, the cigarette is positioned within the device, and after use, the used cigarette is removed from the device and replaced with another cigarette.

Abstract: Systems, methods and software merge a Virtual World, Live Event and Entertainment Channel, thus creating “The Perfect Storm” of gaming and entertainment whereby the characters of a social network game (e.g., an online fantasy sports league) are represented by human beings who register to be avatars of characters supported by a “Character Service Center,” while players compete to bring avatars to life in a Real World event (e.g., a Real World sports league), where the human beings behind the avatars compete for prizes while staying in character, as these competitors and players are incentivized by a “Collaboration Incentive Platform.

Abstract: A method of facilitating formation of a via in an inorganic substrate may include applying a single-sided acidic wet etching process to a first surface of the inorganic substrate in a first state in which the inorganic substrate has a mask layer set covering a second surface of the inorganic substrate; and applying a double-sided acidic wet etching process to the first surface and the second surface of the inorganic substrate after completion of the single-sided acidic wet etching process and in a second state in which the inorganic substrate has had the mask layer set removed from the second surface of the inorganic substrate.

Abstract: A computer-implemented method is provided for detecting actionable transaction risks. The method includes grouping an inbound event related to a transaction with a target event group and determining an actionable group of events that are deemed high risk and a non-actionable group of non-actionable events that are deemed low risk. The method also includes evaluating the target event group relative to the actionable and non-actionable groups of events. This includes computing a first distance between the target event group and the non-actionable group and a second distance between the target event group and actionable group. The first distance is compared with the second distance to determine if the target event group, including the inbound event, is closer to the actionable group or to the nonactionable group.