Patents by Inventor David I. Israel
David I. Israel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9938243Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.Type: GrantFiled: September 7, 2017Date of Patent: April 10, 2018Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Peter Kumpalume, Oliver Schon, Christine Patricia Donahue, Ghotas Evindar, David I. Israel, David Paolella, Letian Kuai, Ninad V. Prabhu
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Publication number: 20170369448Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.Type: ApplicationFiled: September 7, 2017Publication date: December 28, 2017Inventors: Peter KUMPALUME, Oliver SCHON, Christine Patricia DONAHUE, Ghotas EVINDAR, David I. ISRAEL, David PAOLELLA, Letian KUAI, Ninad V. PRABHU
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Patent number: 9809558Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.Type: GrantFiled: October 1, 2014Date of Patent: November 7, 2017Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Peter Kumpalume, Oliver Schon, Christine Patricia Donahue, Ghotas Evindar, David I. Israel, David Paolella, Letian Kuai, Ninad V. Prabhu
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Publication number: 20160221962Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.Type: ApplicationFiled: October 1, 2014Publication date: August 4, 2016Inventors: Peter KUMPALUME, Oliver SCHON, Christine Patricia DONAHUE, Ghotas EVINDAR, David I. ISRAEL, David PAOLELLA, Letian KUAI, Ninad V. PRABHU
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Patent number: 8598089Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.Type: GrantFiled: March 4, 2011Date of Patent: December 3, 2013Assignee: GlaxoSmithKline LLCInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Patent number: 8410028Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.Type: GrantFiled: March 18, 2011Date of Patent: April 2, 2013Assignee: GlaxoSmithKline LLCInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Publication number: 20120245040Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.Type: ApplicationFiled: March 4, 2011Publication date: September 27, 2012Applicant: GlaxoSmithKlineInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Publication number: 20120071329Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.Type: ApplicationFiled: March 18, 2011Publication date: March 22, 2012Applicant: GlaxoSmithKline LLCInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Publication number: 20110251089Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.Type: ApplicationFiled: March 18, 2011Publication date: October 13, 2011Applicant: GlaxoSmithKlineInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Patent number: 7989395Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.Type: GrantFiled: October 23, 2006Date of Patent: August 2, 2011Assignee: GlaxoSmithKline LLCInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Patent number: 7972992Abstract: The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.Type: GrantFiled: December 17, 2004Date of Patent: July 5, 2011Assignee: Praecis Pharmaceuticals, Inc.Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Patent number: 7972994Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides.Type: GrantFiled: June 9, 2006Date of Patent: July 5, 2011Assignee: GlaxoSmithKline LLCInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paulo A. Centrella, Raksha A. Acharya
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Publication number: 20110136697Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.Type: ApplicationFiled: February 9, 2011Publication date: June 9, 2011Applicant: Praecis Pharmaceuticals IncorporatedInventors: Barry MORGAN, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Patent number: 7935658Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide.Type: GrantFiled: October 4, 2007Date of Patent: May 3, 2011Assignee: Praecis Pharmaceuticals, Inc.Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Publication number: 20090062147Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.Type: ApplicationFiled: October 4, 2007Publication date: March 5, 2009Applicant: Praecis Pharmaceuticals IncorporatedInventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
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Publication number: 20020133001Abstract: The present invention provides therapeutic agents suitable for treating an amyloidogenic disorder, as well as pharmaceutical compositions comprising the therapeutic agents and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an amyloidogenic disorder, e.g., Alzheimer's disease, in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.Type: ApplicationFiled: November 27, 2001Publication date: September 19, 2002Applicant: Praecis Pharmaceuticals Inc.Inventors: Malcolm L. Gefter, David I. Israel, John L. Joyal, Michael Gosselin
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Patent number: 6214795Abstract: This invention provides peptide compounds that bind to either a fibroblast growth factor (FGF) or a fibroblast growth factor receptor (FGFR) and, accordingly, are useful for modulating FGFR activity. Preferably, the FGFR is FGFR2-IIIC. Preferably, the FGF is basic FGF. Preferably the peptide compound comprises an amino acid sequence: (Y/F)-(L/F/I)-(R/D/E/S/Y/G)-(Q/L/Y)-Y-(M/L/K/R)-(L/M/D/E/N/S)-(R/L/S/T)-(L/F/M/V) (SEQ ID NO: 1). The invention further comprises pharmaceutical compositions comprising the peptide compounds of the invention and a pharmaceutically acceptable carrier. The invention still further provides methods of modulating FGFR activity using the peptide compounds of the invention.Type: GrantFiled: November 12, 1996Date of Patent: April 10, 2001Assignee: Praecis Pharmaceuticals, Inc.Inventors: Howard Benjamin, Ling Chai, Mark A. Findeis, William Goodwin, Arvind Hundal, David I. Israel, Michael Kelley, Martin P. Keough, Kuanghui Lu, Farah Natoli, Alicia Peticolas, Ethan R. Signer, Malcolm L. Gefter
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Patent number: 5981190Abstract: The present invention is directed to methods and reagents for performing rapid, detailed analysis of the spatial and temporal expression of genes. The method uses linker tags in a head to tail array in a serial analysis of gene expression.Type: GrantFiled: January 8, 1998Date of Patent: November 9, 1999Assignee: Ontogeny, Inc.Inventor: David I. Israel
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Patent number: 5516654Abstract: A process for increasing the yield of recombinant bone-inducing proteins of the BMP-2 family is provided, wherein dextran sulfate is added to the culture medium in which cells expressing the proteins are grown.Type: GrantFiled: January 27, 1994Date of Patent: May 14, 1996Assignee: Genetics Institute, Inc.Inventor: David I. Israel
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Patent number: 5318898Abstract: An improved process for producing recombinant bone-inducing protein of the BMP-2 family as described. A suitable mammalian host cell transformed with a DNA encoding the protein is cultured in an appropriate culture medium to which is added about 10 to 1000 .mu.g/ml dextran sulfate. The presence of dextran sulfate in the medium results in an increased yield of recombinant bone-inducing protein.Type: GrantFiled: April 2, 1991Date of Patent: June 7, 1994Assignee: Genetics Institute, Inc.Inventor: David I. Israel